Assessment of inflammatory cytokines in exhaled breath condensate and exposure to mixtures of organic pollutants in brick workers

Berumen-Rodríguez, Alejandra Abigail; Alcántara-Quintana, Luz Eugenia; Pérez‐Vázquez, Francisco Javier; Zamora-Mendoza, Blanca Nohemí; León-Martínez, Lorena Díaz de; Barriga, Fernando J.A.S.; Flores-Ramírez, Rogelio

doi:10.1007/s11356-022-23071-z

Cited by 4 publications

(2 citation statements)

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“…Fifty-eight (56%) reported data on brick kiln pollution, 6,8,15,16, 25 (24%) on health, 5, and 21 (20%) on both pollution and health. 7,9,[94][95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111] We mapped countries where brick kiln research was conducted in Figure 2. Most were in South Asia (Online Supplement).…”

Section: Literature Searchmentioning

confidence: 99%

Brick kiln pollution and its impact on health: A systematic review and meta-analysis

Nicolaou,

Sylvies,

Veloso

et al. 2023

Preprint

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BackgroundBrick kiln emissions adversely affect air quality and the health of workers and individuals living near the kilns; however, evidence of the impacts of brick kiln pollution remains limited.MethodsWe conducted a systematic review of brick kiln pollution (emissions, source contributions and personal exposures) and its effects on health. We extracted articles from electronic databases and through manual citation searching. We estimated pooled, sample-size-weighted means and standard deviations for personal exposures by job type; computed mean emission factors and pollutant concentrations by brick kiln design; and meta-analyzed differences in means or proportions for health outcomes between brick kiln workers (BKWs) and controls or for participants living near or far away from kilns.ResultsOur search yielded 1015 articles; 208 (20%) were assessed for eligibility and 101 (10%) were included in our review. We identified three additional studies through manual searching. Of 104 studies, 74 (71%) were conducted in South Asia. The most evaluated pollutants were particulate matter (PM; n=48), sulfur dioxide (SO2; n=24) and carbon monoxide (CO; n=22), and the most evaluated health outcomes were respiratory health (n=34) and musculoskeletal disorders (n=9). PM and CO emissions were higher among traditional than improved brick kilns. Mean respirable silica exposures were only measured in 4 (4%) studies and were as high as 620 μg/m3, exceeding the NIOSH recommended exposure limit by a factor of over 12. BKWs had consistently worse lung function, more respiratory symptoms, more musculoskeletal complaints, and more inflammation when compared to unexposed participants across studies; however, most studies had a small sample size and did not fully describe methods used for sampling or data collection.DiscussionOn average, BKWs had worse health outcomes when compared to unexposed controls but study quality supporting the evidence was low. Few studies reported silica concentrations or personal exposures, but the few that did suggest that exposures are high. Further research is needed to better understand the relationship between brick kiln pollution and health among workers, and to evaluate exposure mitigation strategies.

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Section: Literature Searchmentioning

confidence: 99%

Brick kiln pollution and its impact on health: A systematic review and meta-analysis

Nicolaou,

Sylvies,

Veloso

et al. 2023

Preprint

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“…Coal particles are chemically complex and can trigger the activation of macrophages, epithelial cells, and fibroblasts; the release of reactive oxygen species (ROS); and the expression of cytokines (Gulumian et al 2006). Proinflammatory cytokines play an important role in the lung inflammatory response and oxidative stress in individuals exposed to occupational pollutants (Berumen-Rodríguez et al 2022; Díaz de Zhou et al 2014). In some populations, exposure to compounds derived from coal mining begins before birth and continues throughout their life cycle (Barn et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the cytotoxic and genotoxic effects in a population chronically exposed to coal mining residues

León-Mejía

Rueda

Pérez

et al. 2023

Environ Sci Pollut Res

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During coal mining activities, many compounds are released into the environment that can negatively impact human health. Particulate matter, polycyclic aromatic hydrocarbons (PAHs), metals, and oxides are part of the complex mixture that can affect nearby populations. Therefore, we designed this study to evaluate the potential cytotoxic and genotoxic effects in individuals chronically exposed to coal residues from peripheral blood lymphocytes and buccal cells. We recruited 150 individuals who lived more than 20 years in La Loma-Colombia and 120 control individuals from the city of Barranquilla without a history of exposure to coal mining. In the cytokinesis-block micronucleus cytome (CBMN-Cyt) assay, significant differences in the frequency of micronucleus (MN), nucleoplasmic bridge (NPB), nuclear bud (NBUD), and apoptotic cells (APOP) were observed between the two groups. In the buccal micronucleus cytome (BM-Cyt) assay, a significant formation of NBUD, karyorrhexis (KRX), karyolysis (KRL), condensed chromatin (CC), and binucleated (BN) cells was observed in the exposed group. Considering the characteristics of the study group, a significant correlation for CBMN-Cyt was found between NBUD and vitamin consumption, between MN or APOP and meat consumption, and between MN and age. Moreover, a significant correlation for BM-Cyt was found between KRL and vitamin consumption or age, and BN versus alcohol consumption. Using Raman spectroscopy, a significant increase in the concentration of DNA/RNA bases, creatinine, polysaccharides, and fatty acids was detected in the urine of individuals exposed to coal mining compared to the control group. These results contribute to the discussion on the effects of coal mining on nearby populations and the development of diseases due to chronic exposure to these residues.

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Brick kiln pollution and its impact on health: A systematic review and meta-analysis

Nicolaou,

Sylvies,

Veloso

et al. 2024

Environmental Research

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Assessment of inflammatory cytokines in exhaled breath condensate and exposure to mixtures of organic pollutants in brick workers

Cited by 4 publications

References 60 publications

Brick kiln pollution and its impact on health: A systematic review and meta-analysis

Brick kiln pollution and its impact on health: A systematic review and meta-analysis

Analysis of the cytotoxic and genotoxic effects in a population chronically exposed to coal mining residues

Brick kiln pollution and its impact on health: A systematic review and meta-analysis

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