Assessment of Immunoglobulin M Enzyme Immunoassays for Diagnosis of Measles

Tipples, Graham; Hamkar, Rasool; Mohktari-Azad, Talat; Gray, Michael J.; Parkyn, Geoff; Head, Carol; Ratnam, Samuel

doi:10.1128/jcm.41.10.4790-4792.2003

Cited by 31 publications

(21 citation statements)

References 15 publications

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“…(19,34,35) .This low observed occurrence in children of vaccination and mothers with a past history of measles be able to explained through the information that these mothers have naturally acquired protection against measles, which provides passive defense to their infants (36) .The attendance of IgM antibodies to MV in serum is analytic of innate measles disease or vaccination.…”

Section: Resultsmentioning

confidence: 99%

Evaluating the prevalence measles virus IgM antibodies for under 2 years children in Diayala governorate

Mohsin¹

2017

DJPS

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The goal of present study was to evaluating the prevalence of measles virus (MV) immunoglobulin M antibodies in children under two year. This study was conducted from the (41%) among children of mothers with unvaccinated or no a past history of measles. Finally, the prevalence of IgM was 2(2.6%) in children who were breast feeding, but 33(37.9%) among non-breastfeeding children. In conclusion, the prevalence of anti-MV IgM was higher among aged (0-8) months. For the more, the prevalence of IgM was higher among females.Additionally prevalence it's higher among unvaccinated children. While prevalence its higher among children of mothers with unvaccinated or no history of measles. Finally, the prevalence it's higher among non-breastfeeding children..

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Section: Resultsmentioning

confidence: 99%

Evaluating the prevalence measles virus IgM antibodies for under 2 years children in Diayala governorate

Mohsin¹

2017

DJPS

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“…Also rise of serum IgM antibody is a biological reaction due to infections (25)(26)(27), the sensitivity and specificity of difference of immunochromatography and had been estimated in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Commercially available EIA kits were used to detect serum antibodies against measles (25)(26)(27). Using serum and extract liquid residual by using real-time RT-PCR and antibody measurement conducted.…”

Section: Evaluation Of the Diagnostic Reagent Using Clinical Samplesmentioning

confidence: 99%

A Study on the Clinical Application of a Rapid Diagnostic Reagent for Measles

Numazaki

2012

ELECTRON J GEN MED

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“…However, in infants less than nine months of age, these antibodies usually reflect placental antibodies transferred from the mother to the child. Detection of measles-specific antibodies is usually performed by enzyme immunoassays 11,12 or by a plaque reduction neutralization (PRN) assay, a technique that measures measles antibodies with the biological capacity to neutralize measles virus in vitro. The PRN assay is considered the gold standard for clinically relevant detection of measles-specific antibody.…”

Section: Introductionmentioning

confidence: 99%

Measles-specific Neutralizing Antibodies in Rural Mozambique: Seroprevalence and Presence in Breast Milk

Mandomando

Naniche

Pasetti³

et al. 2008

The American Journal of Tropical Medicine and Hygiene

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Abstract. In Mozambique, as in many sub-Saharan countries, measles remains a public health problem. We conducted cross-sectional surveys in which we assessed measles-specific antibodies in serum and breast milk by plaque reduction neutralization (PRN) assay and measles secretory IgA in breast milk by enzyme-linked immunosorbent assay. A total of 151 persons < 1 month to 23 years of age were surveyed; 81 (53.6%) of 151 had PRN titers equal to or above the protective level (Ն 200 mIU/mL). We found many serosusceptible persons, including 20.5% in whom no PRN antibody was detected. Almost all (96%) infants 6-8 months of age had non-protective PRN titers. Overall, 20.7% (6 of 29) of persons known to have received measles vaccine had non-protective titers. The geometric mean titer (GMT) of breast milk PRN antibodies was 41.6 mIU/mL (95% confidence interval [CI] ‫ס‬ 34.0-51.0 mIU/mL) and the secretory IgA GMT was 227.6 (EU/mL) (95% CI ‫ס‬ 179.1-289.1 EU/mL). The PRN titers of breast milk tended to increase with age. A notable proportion of the population in Manhiça, Mozambique apparently remains susceptible to clinical measles despite recent mass vaccination campaigns.

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Assessment of Immunoglobulin M Enzyme Immunoassays for Diagnosis of Measles

Cited by 31 publications

References 15 publications

Evaluating the prevalence measles virus IgM antibodies for under 2 years children in Diayala governorate

Evaluating the prevalence measles virus IgM antibodies for under 2 years children in Diayala governorate

A Study on the Clinical Application of a Rapid Diagnostic Reagent for Measles

Measles-specific Neutralizing Antibodies in Rural Mozambique: Seroprevalence and Presence in Breast Milk

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