Assessment of IL-31 levels and disease severity in children with atopic dermatitis

Özçeker, Deniz; Bulut, Muhammet; Özbay, Aydan; Dilek, Fatih; Koser, Murat; Tamay, Zeynep; Güler, Nermin

doi:10.1016/j.aller.2017.10.005

Cited by 16 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This rate is lower than what is reported in the former study by Ricci et al [12], which was performed in a pediatric population with a similar number of cases. The previous studies conducted on pediatric AD patients in Turkey have also reported larger proportions of severe cases [13][14][15]. In the UK, however, the rates of mild, moderate, and severe AD in children reported to be 82, 12, and 6%, respectively; which are comparable to our results [16].…”

Section: Discussionsupporting

confidence: 89%

What plays a role in the severity of atopic dermatitis in children?

Cansever

Oruc

2021

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim Determining the characteristics and risk factors of severe disease is extremely important to combat atopic dermatitis (AD), which has recently shown increasing prevalence. In this study, we aimed to investigate the clinical characteristics of pediatric patients with AD and identifying the factors associated with the severity of the disease. Materials and methods A total of 304 pediatric patients diagnosed with atopic dermatitis were included in the study. The patients’ age at admission, age at onset of symptoms, the presence of atopy history in their family, eosinophil levels obtained from blood counts were recorded, together with the data of cigarette exposure, and area of residence. Disease severity was determined according to the SCORAD index. Epidermal prick tests (EPT) were applied to all patients. Results There was a negative correlation between the SCORAD score and both age at admission (r = 0.277, p < 0.001) and age at onset of the symptoms (r = –0.474, p < 0.001). Food sensitization rates were higher in individuals with moderate-severe disease (90.7% vs. 23.1%; p < 0.001) and patients with food allergy (FA) had significantly higher SCORAD scores [33 (IQR: 22–44) vs. 14 (IQR: 12–16); p < 0.001]. SCORAD scores of the individuals living in rural areas were higher than the ones living in urban [22 (IQR: 15–39.5) vs. 15 (IQR: 12–22); p < 0.001]. Familial atopy history was more common in patients with moderate-severe disease (66.5% vs. 17.5%; p < 0.001). The SCORAD scores were higher in patients exposed to passive smoking [21 (IQR:14.75–38) vs. 13 (IQR: 12–16); p < 0.001]. The eosinophil count found to be positively correlated with SCORAD scores (r = 0.531, p < 0.001). Conclusion Our findings show that early-onset, food sensitivity, living in rural areas, having familial atopy history and passive cigarette smoke exposure play a role in severe AD. Since it is remarkably correlated with SCORAD scores, eosinophil count can be used as a marker to assess the severity of AD in children.

show abstract

Section: Discussionsupporting

confidence: 89%

What plays a role in the severity of atopic dermatitis in children?

Cansever

Oruc

2021

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…This lack of significant association was also demonstrated by other studies. 29,30 However, a systematic review on IL-31 found serum IL-31 levels to correlate with pruritus intensity indicating that IL-31 is a key mediator in inducing pruritus. 31 The levels of interleukins in Ps did not correlate with disease or itch severity (measured by PASI/BSA, VAS, PGS) which indicates that other mediators in Ps pathogenesis are also implicated.…”

Section: Discussionmentioning

confidence: 99%

<p>IL-33/13 Axis and IL-4/31 Axis Play Distinct Roles in Inflammatory Process and Itch in Psoriasis and Atopic Dermatitis</p>

Bodoor¹,

Al‐Qarqaz²,

Heis³

et al. 2020

CCID

View full text Add to dashboard Cite

Background: Pruritus is the most common symptom in patients with skin disease. Psoriasis and atopic dermatitis are clinically distinct inflammatory diseases. Interleukins are cytokines which play key roles in inflammatory signaling pathways. Materials and Methods: Cross-sectional study was conducted among patients with psoriasis and atopic dermatitis: 59 psoriatic patients, 56 AD patients, and 49 matched healthy controls. Interleukins 4, 13, 31, 33 serum levels were assayed by ELISA and results were compared using SPSS. Itch severity and disease severity were measured and correlation with interleukin levels was determined using SPSS. Results: The serum levels of IL-4,-13,-31,-33 were elevated in atopic dermatitis patients compared to controls. Itch and disease severity were not correlated with elevated serum levels of these interleukins. In psoriasis, the levels of IL-4 and-31 were elevated compared to controls, whereas the levels of IL-13 and-33 were lower than controls. The levels of measured interleukins in psoriasis did not correlate with itch and disease severity. Conclusion: IL-31 is the key mediator for pruritus in both AD and Ps patients. IL-4/31 axis and IL-33/13 axis play distinct roles in the pathogenesis of Atopic dermatitis and Psoriasis. Interleukin serum levels were not correlated with itch and disease severity in both conditions.

show abstract

“…18,116,117 Curiously, despite some reports on the correlation of the ''itch cytokine,'' IL-31, with disease severity, 62,118 more evidence is accumulating on the lack of such correlation. 102,[119][120][121] Predictive biomarkers Tissue biomarkers predicting disease onset include TARC and IgE in the umbilical cords of newborns 122,123 and natural moisturizing factor levels in neonates' skin, 124 which are known to strongly correlate with transepidermal water loss, 23 another predictor of AD development in newborns. 125,126 Moisturizers can prevent AD in high-risk infants, 127 and were shown to alter skin microbiome and reduce skin pH in this population.…”

Section: Biomarkers That Failed To Show Consistent Correlation With Smentioning

confidence: 99%

Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council

Renert‐Yuval

Thyssen

Bissonnette

et al. 2021

Journal of Allergy and Clinical Immunology

182

210

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a common yet complex skin disease, posing a therapeutic challenge with increasingly recognized different phenotypes among variable patient populations. Because therapeutic response may vary on the basis of heterogeneous clinical and molecular phenotypes, a shift toward precision medicine approaches may improve AD management. Herein, we will consider biomarkers as potential instruments in the toolbox of precision medicine in AD and will review the process of biomarker development and validation, the opinion of AD experts on the use of biomarkers, types of biomarkers, encompassing biomarkers that may improve AD diagnosis, biomarkers reflecting disease severity, and those potentially predicting AD development, concomitant atopic diseases, or therapeutic response, and current practice of biomarkers in AD. We found that chemokine C-C motif ligand 17/thymus and activation-regulated chemokine, a chemoattractant of T H 2 cells, has currently the greatest evidence for robust correlation with AD clinical severity, at both baseline and during therapy, by using the recommendations, assessment, development, and evaluation approach. Although the potential of biomarkers in AD is yet to be fully elucidated, due to the complexity of the disease, a comprehensive approach taking into account both clinical and reliable, AD-specific biomarker evaluations would further facilitate AD research and improve patient management.

show abstract

Assessment of IL-31 levels and disease severity in children with atopic dermatitis

Abstract: IL-31 levels were significantly higher in AD patients compared to control group but irrelevant to the disease severity.

Cited by 16 publications

References 16 publications

What plays a role in the severity of atopic dermatitis in children?

What plays a role in the severity of atopic dermatitis in children?

<p>IL-33/13 Axis and IL-4/31 Axis Play Distinct Roles in Inflammatory Process and Itch in Psoriasis and Atopic Dermatitis</p>

Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council

Contact Info

Product

Resources

About