Assessment of hyperpolarized <sup>3</sup>He lung MRI for regional evaluation of interventional therapy: A pilot study in pediatric cystic fibrosis

Woodhouse, Neil; Wild, Jim M.; Beek, Edwin Jacques Rudolph van; Hoggard, Nigel; Barker, Nicki; Taylor, Christopher J.

doi:10.1002/jmri.21949

Cited by 72 publications

(76 citation statements)

References 30 publications

(56 reference statements)

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“…HP gas MRI's capacity to show precise locations in the lungs where gas reaches, and locations where gas does not reach, has clear clinical and biological relevance. Woodhouse et al (28) tested reproducibility of HP 3 He MR images on five CF patients aged 6-15 and found that scans in their study showed reproducibility, providing preliminary support for fulfilling the third key characteristic above.…”

Section: Discussionmentioning

confidence: 87%

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Sun

O’Sullivan

Roche

et al. 2011

Magnetic Resonance Imaging

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Purpose: To use hyperpolarized (HP) 3 He MR imaging to assess functional lung ventilation in subjects with cystic fibrosis (CF) before and after treatment. Materials and Methods: We performed HP 3He static ventilation MRI scans on three subjects, using a Philips 3.0 Tesla (T) Achieva MRI scanner, before and after 11 days of in-patient treatment with combined intravenous and inhaled therapies for pulmonary exacerbations of CF. We also collected spirometry data. We quantified pulmonary ventilation volume measured with HP 3 He MRI using an advanced semi-automated analysis technique.Results: Following 11 days of treatment with intravenous antibiotics, hypertonic saline, and rhDNase, HP 3 He MR images in one subject displayed a 25% increase in total ventilation volume. Total ventilation volume in the other two subjects slightly decreased. All three subjects showed increases in FEV 1 and FVC following treatment. Conclusion:In all subjects, the HP 3 He MR images provided detailed information on precisely where in the lungs gas was reaching. These data provide additional support for the conclusion that HP noble gas MRI can be a powerful tool for evaluating lung ventilation in patients with cystic fibrosis, but also raise important questions about the correlation between spirometry and HP gas MRI measurements.

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Section: Discussionmentioning

confidence: 87%

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Sun

O’Sullivan

Roche

et al. 2011

Magnetic Resonance Imaging

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“…Other studies have assessed the response of a variety of indices to short-term physiotherapy in stable patients with CF. One study used helium magnetic resonance imaging pre-and post-airway clearance to assess the short-term changes of physiotherapy [30]. This demonstrated that although there was a change in ventilation there was no overall improvement in ventilation inhomogeneity.…”

Section: Discussionmentioning

confidence: 99%

The reproducibility and responsiveness of the lung clearance index in bronchiectasis

et al. 2015

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Lung clearance index (LCI) is a potential clinical outcome marker in bronchiectasis. Its responsiveness to therapeutic intervention has not been determined. This study evaluates its responsiveness to a session of physiotherapy and intravenous antibiotic treatment of an exacerbation.32 stable and 32 exacerbating bronchiectasis patients and 26 healthy controls were recruited. Patients had LCI and lung function performed before and after physiotherapy on two separate occasions in the stable patients and at the beginning and end of an intravenous antibiotic course in the exacerbating patients.LCI was reproducible between visits in 25 stable patients, with an intraclass correlation of 0.978 (0.948, 0.991; p<0.001). There was no significant difference in LCI (mean±SD) between stable 11.91±3.39 and exacerbating patients 12.76±3.47, but LCI was significantly higher in both bronchiectasis groups compared with healthy controls (7.36±0.99) ( p<0.001). Forced expiratory volume in 1 s improved after physiotherapy, as did alveolar volume after intravenous antibiotics, but LCI did not change significantly.LCI is reproducible in stable bronchiectasis but unlike conventional lung function tests, is unresponsive to two short-term interventions and hence is unlikely to be a useful clinical tool for short-term acute assessment in these patients. Further evaluation is required to establish its role in milder disease and in the evaluation of long-term interventions. @ERSpublications LCI is unresponsive to airway clearance or i.v. antibiotic treatment of a pulmonary exacerbation in bronchiectasis

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“…However, this parameter can be assessed only in reasonably well ventilated lung tissue. To date, very few studies using 3 He MRI have reported on therapeutic interventions: preliminary results of bronchodilator therapy in asthmatics (Samee et al, 2003) and immediate effects of standard chest physiotherapy on regional ventilation with spirometry unchanged in patients with CF (Woodhouse et al, 2009 (Patz et al, 2008;Cleveland et al, 2010). However, the anesthetic properties of Xe are of some concern.…”

Section: Imaging In Respiratory Diseases: From Animal Models To Patientsmentioning

confidence: 99%

A View on Imaging in Drug Research and Development for Respiratory Diseases

Echteld¹,

Beckmann²

2011

J Pharmacol Exp Ther

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With the incidence of respiratory diseases increasing throughout the world, new therapies are needed. This review provides a short overview of different imaging techniques of interest for drug discovery and development within the pulmonary disease area. The focus is on studies performed in both animals and humans, which are of importance for understanding pathophysiological aspects and evaluating new drugs. Rather than emphasizing particular lung diseases, the noninvasive diagnosis and quantification of a number of characteristics related to several pathological conditions of the lung are addressed: inflammation, mucus secretion and clearance, emphysema, ventilation, perfusion, fibrosis, airway remodeling, and pulmonary arterial hypertension. Techniques are discussed based on their present use or potential future utilization in the context of drug studies.

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Assessment of hyperpolarized ³He lung MRI for regional evaluation of interventional therapy: A pilot study in pediatric cystic fibrosis

Cited by 72 publications

References 30 publications

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

The reproducibility and responsiveness of the lung clearance index in bronchiectasis

A View on Imaging in Drug Research and Development for Respiratory Diseases

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Assessment of hyperpolarized 3He lung MRI for regional evaluation of interventional therapy: A pilot study in pediatric cystic fibrosis

Cited by 72 publications

References 30 publications

Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients

Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients

The reproducibility and responsiveness of the lung clearance index in bronchiectasis

A View on Imaging in Drug Research and Development for Respiratory Diseases

Contact Info

Product

Resources

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Assessment of hyperpolarized ³He lung MRI for regional evaluation of interventional therapy: A pilot study in pediatric cystic fibrosis

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients