Assessment of hypercoagulable states by measurement of activation fragments and peptides

Boisclair, Michael D.

doi:10.1016/0268-960x(90)90014-j

Cited by 116 publications

(70 citation statements)

References 98 publications

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“…When coagulation is activated, cleavage parameters, including F1 + 2 and D-D, are released into circulation [35]. Our data show for the first time that patients with ED present markers of coagulation activation and reduced fibrinolysis higher than patients without ED, which points for a role of unbalanced haemostasis in the pathogenesis of diabetic ED.…”

Section: Discussionmentioning

confidence: 55%

Erectile and endothelial dysfunction in Type II diabetes: a possible link

et al. 2001

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Erectile dysfunction (ED) is a common complication and an important cause of decreased quality of life in men with diabetes. These patients present a risk of ED three-fold higher than the general population; the prevalence of ED increases with age, but in diabetic men it can occur 10 to 15 years earlier regardless of their insulin dependency status [1].The causes of ED in diabetic patients can be multifactorial, involving mainly vascular, neurological and Diabetologia (2001) AbstractAims/hypothesis. The aim of this study was to evaluate the relation between erectile dysfunction and endothelial functions, coagulation activation, peripheral and autonomic neuropathy in men with Type II (non-insulin-dependent) diabetes mellitus. Methods. We studied 30 Type II diabetic patients with symptomatic erectile dysfunction and 30 potent diabetic patients matched for age and disease. Endothelial functions were assessed with the l-arginine test, plasma thrombomodulin and cell adhesion molecules circulating concentrations. Haemostasis was evaluated with markers of thrombin activation and fibrinolysis. Quantitative sensory testing (vibratory, warming, and heat-pain thresholds), cardiovascular reflex tests and 24-h blood pressure monitoring were used to assess peripheral or autonomic neuropathy. Results. Mean erectile score and HbA 1 c were 10.5 5.8 and 8.3 1.6 % in patients with erectile dysfunction, and 24.0 0.7 and 6.8 1.4 % in those without erectile dysfunction, respectively (p < 0.001); there was a significant relation between HbA 1 c and erectile function score in patients with erectile dysfunction (r = ±0.45, p = 0.02). The decrease in blood pressure and platelet aggregation in response to l-arginine was lower (p < 0.05±0.02) in patients with erectile dysfunction, whereas soluble thrombomodulin, P-selectin and intercellular cell ahhesion molecule-1 concentrations were higher (p < 0.05±0.02). Indices of coagulation activation (F1 + 2 and d-dimers) and reduced fibrinolysis (PAI-1) were also found to be higher in erectile dysfunction patients. Heat-pain and warm perception thresholds, as well as cardiovascular reflex tests, were most commonly abnormal in patients with erectile dysfunction (p < 0.05). In multivariate analysis, HbA 1 c , MBP response to l-arginine, P-selectin, indices of coagulation, and quantitative sensory testing were independent predictors of erectile function score. Conclusion/interpretation. Erectile dysfunction in diabetic men correlates with endothelial dysfunction. A reduced nitric oxide activity might provide a unifying explanation. [Diabetologia (2001

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Section: Discussionmentioning

confidence: 55%

Erectile and endothelial dysfunction in Type II diabetes: a possible link

et al. 2001

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“…Elevated levels of prothrombin fragments 1+2 and TAT are indicative of thrombin generation [11]. Similarly, low levels of PAP, D-dimer, and t-PA activity may be indicative of hypofibrinolysis [12].…”

Section: Discussionmentioning

confidence: 99%

Coagulation and Fibrinolysis Markers and Risk of Dementia

Bots

Breteler²,

Kooten

et al. 1998

Pathophysiol Haemos Thromb

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We performed a cross-sectional case-control study among 277 subjects with dementia and 298 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, with the objective to evaluate the association of indicators of coagulability, fibrinogen, prothrombin fragments 1+2, thrombin-antithrombin complex (TAT), and indicators of fibrinolysis, plasmin-inhibitor complex, D-dimer and tissue-type plasminogen activator (t-PA) with dementia. Increased levels of TAT, D-dimer and t-PA activity were associated with an increased risk of dementia. Additional stratified analyses indicated that an increased TAT level was the primary factor related to dementia. The present study provides evidence that predominantly increased thrombin generation is associated with dementia.

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“…In a previous study, the increase of plasma D-dimer levels showed sensitivity to various mild physiological and pathological prethrombotic conditions (normal aging, atherosclerotic disease, bed-ridden state, malignancy, etc.) as well as to overt thrombosis (disseminated intravascular coagulation, deep vein thrombosis, and pulmonary thromboembolism) [33][34][35] . In our high-stress group, the PIC, an activation marker of fibrinolysis, and tPA antigen levels after the earthquake were also increased ( Figure 6).…”

Section: Earthquake-induced Potentiation Of Acute Risk Factorsmentioning

confidence: 99%