Assessment of Hupu Gum for Its Carrier Property in the Design and Evaluation of Solid Mixtures of Poorly Water Soluble Drug - Rofecoxib

Abstract

There are no reports about the pharmaceutical applications of hupu gum (HG). Hence the present study was undertaken to test its suitability in the dissolution enhancement of poorly water soluble drug. Rofecoxib (RFB) was taken as model drug. For comparison solid mixtures were prepared with carriers such as poly vinyl pyrrolidone (PVP), sodium starch glycollate (SSG) and guar gum (GG). Physical mixing (PM), co-grinding (CG), kneading (KT) and solvent evaporation (SE) techniques were used to prepare the solid mixtures, using all the carriers in different carrier and drug ratios. The solid mixtures were characterized by powder X-ray diffraction (XRD) and Fourier-transformed infrared spectroscopy (FTIR). There was a significant improvement in the dissolution rate of solid mixtures of HG, when compared with the solid mixtures of other carriers. There was an increase in dissolution rate with increase in concentration of HG upto 1:1 ratio of carrier and drug. No drug-carrier interaction was found by FTIR studies. XRD studies indicated reduction in crystallinity of the drug with increase in HG concentration. Hence HG could be a useful carrier for the dissolution enhancement of poorly water soluble drugs.

Biopharmaceutical Process of Diclofenac Multiparticulate Systems for Chronotherapy of Rheumatoid Arthritis

“…Multi-particulate formulations are composed of immediate-and controlled-release particulates and are superior because they present diverse drug delivery patterns in a circadian fashion. 10,11 DC, a regular medication used in the management of RA, was chosen as the model drug in this study. 12 The aim was to develop multi-particulate systems of DC-containing immediate-and pulsatile-controlled release pellets using non-pareil sugar seeds to avoid gastric mucosal damage and enable pulsatile release in the small intestine.…”