Assessment of human exposure to environmental sources of nickel in Europe: Inhalation exposure

Buekers, Jurgen; Brouwere, Katleen De; Lefebvre, Wouter; Willems, Hanny; Vandenbroele, Marleen; Sprang, Patrick Van; Eliat-Eliat, Maxime; Hicks, Keegan A.; Schlekat, Christian E.; Oller, Adriana R.

doi:10.1016/j.scitotenv.2015.02.092

Cited by 15 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Threshold Values a Reference NACD (human) Dermal-NOAEL = 0.44 µg Ni/cm 2 skin/day a [267] Oral-BMDL 0.1 = 4.3 µg Ni/kg bw/day adult (in addition to diet) [145] Respiratory cancer (human) Inhalation-practical threshold = 0.1 mg Ni/m 3 inhalable aerosol [13] Inhalation-practical threshold = 0.5 µg Ni/m 3 ng/m 3 PM10 aerosol [268] Respiratory non cancer (animal) Inhalation-NOAEC = 0.03 mg/m 3 (Ni sulfate) respirable aerosol [13] Inhalation-NOAEC = 9.4 µg/m 3 (Ni sulfate) PM10 aerosol [268] Reproductive (animal) Oral-BMDL 0.05 = 1.8 mg Ni/kg bw/day adult [145] Environmental Health Effects [194] a Values are based on, or derived from, the most bioavailable chemical form of nickel (i.e., water soluble nickel compounds) but are generally applied to "total nickel".…”

Section: Endpoint (Underlying Studies and Data)mentioning

confidence: 99%

Concise Review of Nickel Human Health Toxicology and Ecotoxicology

Buxton¹,

Garman²,

Heim³

et al. 2019

Inorganics

Self Cite

155

View full text Add to dashboard Cite

Nickel (Ni) metal and Ni compounds are widely used in applications like stainless steel, alloys, and batteries. Nickel is a naturally occurring element in water, soil, air, and living organisms, and is essential to microorganisms and plants. Thus, human and environmental nickel exposures are ubiquitous. Production and use of nickel and its compounds can, however, result in additional exposures to humans and the environment. Notable human health toxicity effects identified from human and/or animal studies include respiratory cancer, non-cancer toxicity effects following inhalation, dermatitis, and reproductive effects. These effects have thresholds, with indirect genotoxic and epigenetic events underlying the threshold mode of action for nickel carcinogenicity. Differences in human toxicity potencies/potentials of different nickel chemical forms are correlated with the bioavailability of the Ni2+ ion at target sites. Likewise, Ni2+ has been demonstrated to be the toxic chemical species in the environment, and models have been developed that account for the influence of abiotic factors on the bioavailability and toxicity of Ni2+ in different habitats. Emerging issues regarding the toxicity of nickel nanoforms and metal mixtures are briefly discussed. This review is unique in its covering of both human and environmental nickel toxicity data.

show abstract

Section: Endpoint (Underlying Studies and Data)mentioning

confidence: 99%

Concise Review of Nickel Human Health Toxicology and Ecotoxicology

Buxton¹,

Garman²,

Heim³

et al. 2019

Inorganics

Self Cite

155

View full text Add to dashboard Cite

show abstract

“…Los modelos de dispersión de Gauss asumen geometría de la pluma ideales, el estado de equilibrio ideal de las emisiones de contaminantes atmosféricos y las condiciones meteorológicas estacionarias, un terreno plano uniforme y una completa conservación de la masa. Con estas asunciones, estos modelos han dado resultados en estudios de calidad de aire (Buekers et al, 2015;Fritz et al, 2015;García et al, 2003).…”

Section: Modelo De Dispersiónunclassified

Dispersión de Contaminantes del Aire (PM10, NO2, CO, COV y HAP) emitidos desde una Estación Modular de Compresión, Tratamiento y Medición de Gas Natural

et al. 2016

View full text Add to dashboard Cite

Este estudio presenta el análisis de la emisión, dispersión y concentración de PM10, CO, NO2, COV y HAP (contaminantes peligroso del aire), emitida desde una estación modular de compresión, tratamiento y medición de gas natural, ubicada en la península de La Guajira al norte de Colombia. Se aplicó el modelo de dispersión Gaussiana WKBK2 para fuentes puntuales para estimar las concentraciones de los contaminantes. Las emisiones de los contaminantes se estimaron utilizando los factores de emisiones de la Agencia Ambiental de los Estados Unidos USEPA. La aplicación del modelo fue validado con PM10 y NO2 medido en un sitio cerca de la planta industrial. Las máximas concentraciones ocurren entre 100 a 200 metros de la fuente. Las concentraciones máxima estimadas de PM10 estaría violando el estándar anual de la Organización Mundial de la Salud. En las cuatro comunidades indígenas ubicadas en la zona, se estimaron niveles menores a los establecidos en la norma Colombiana.

show abstract

“…By contrast, the general population is exposed to nickel primarily through the diet, with a typical intake of 70-250 lg Ni/day, as nickel is naturally present in air, soil, water, plants, and foods (predominantly as complex oxidic forms in soil, an ionic form of Ni in water, and complex organic molecules containing Ni in plants and food) (ATSDR 2005;IARC 2012;De Brouwere et al 2012;NTP 2016;Buxton et al 2019). Inhalation of nickel from the ambient air, which is typically present in the ng/m 3 range (Buekers et al 2015) and includes primarily oxidic and soluble forms of nickel, contributes less than 1% to aggregated nickel exposure from all sources, and, thus, is considered a minor route of exposure for the general population (De Brouwere et al 2012;IARC 2012), whose overall exposure to nickel from all potential sources is generally low (ATSDR 2005;De Brouwere et al 2012;NTP 2016).…”

Section: Introductionmentioning

confidence: 99%

Systematic review of the potential respiratory carcinogenicity of metallic nickel in humans

Prueitt

Chang

et al. 2020

Critical Reviews in Toxicology

View full text Add to dashboard Cite

The inhalation of dust containing certain nickel compounds has been associated with an increased risk of lung and nasal cancers in occupational studies of workers who process or refine sulfidic nickel ores and are exposed to relatively high levels of mixtures of water-soluble, sulfidic, oxidic, and/or metallic forms of nickel. We conducted a systematic review of the potential carcinogenicity of metallic nickel, focusing on cancers of the respiratory tract. We evaluated the quality and risk of bias (RoB) of the relevant epidemiology, experimental animal, and in vitro mechanistic studies using the National Toxicology Program's Office of Health Assessment and Translation (OHAT) RoB Rating Tool. We then used a systematic review protocol based on the OHAT approach to critically assess whether metallic nickel should be considered a human respiratory carcinogen. Our evaluation of the epidemiology studies indicates that there is no substantive evidence of increased respiratory cancer risk in workers exposed predominantly to metallic nickel. Animal evidence indicates that metallic nickel does not increase the incidence of respiratory tumors in rodents exposed by inhalation. The in vitro studies are limited in value, as they bypass normal clearance mechanisms. Nevertheless, the mechanistic evidence indicates that metallic nickel is not mutagenic but can induce DNA strand breaks under certain conditions. Based on a standard framework for assessing causality, we conclude that the evidence does not support a causal relationship between metallic nickel exposure and respiratory cancer in humans.

show abstract

Assessment of human exposure to environmental sources of nickel in Europe: Inhalation exposure

Cited by 15 publications

References 37 publications

Concise Review of Nickel Human Health Toxicology and Ecotoxicology

Concise Review of Nickel Human Health Toxicology and Ecotoxicology

Dispersión de Contaminantes del Aire (PM10, NO2, CO, COV y HAP) emitidos desde una Estación Modular de Compresión, Tratamiento y Medición de Gas Natural

Systematic review of the potential respiratory carcinogenicity of metallic nickel in humans

Contact Info

Product

Resources

About