Assessment of human effective absorbed dose of 67 Ga–ECC based on biodistribution rat data

Shanehsazzadeh, Saeed; Yousefnia, Hassan; Lahooti, Afsaneh; Zolghadri, Samaneh; Jalilian, Amir Reza; Afarideh, H.

doi:10.1007/s12149-014-0917-7

Cited by 10 publications

(17 citation statements)

References 16 publications

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“…In continuation to previous experiences in estimation of human effective dose from rodents' data [16][17][18][19][20][21][22] and to extend former studies [9,10,23], we attempted to compare the biodistribution data of intravenously (iv) injection of 67 Ga-DOTA-Gamma-aminobutyric acid (GABA)-Bombesin ( 67 Ga-BBN) and 99m Tc-hydrazinonicotinamide (HYNIC)-GABA-Bombesin ( 99m Tc-BBN) as well as a prediction of the human absorbed dose of each tracer from mouse data.…”

Section: Introductionmentioning

confidence: 83%

“…In order to minimize the uncertainties' all the samples counts were higher than 10,000, which results SD of less than 1 %. The percentage of injected dose per gram (ID/g %) of each organ was measured by direct counting from mouse data from 12 harvested organs (based on the area under the curve of 140.51 and 184 keV for 99m Tc and 67 Ga respectively, using an HPGe detector) [15,17,18].…”

Section: Methodsmentioning

confidence: 99%

“…Uncertainties in the determinations were minimal, because each assay collected at least 10,000 counts (area under the selected peak), which results the standard deviation (SD) of less than 1 %. In all measurements, we try to keep same geometry and same volume in order to prevent overestimation and underestimation in dose measurements [28]. All samples were background subtracted and decay correction was not considered for all measurements, and similar samples were averaged together.…”

Section: Measurement Of Activitymentioning

confidence: 99%

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Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

Shanehsazzadeh

Lahooti

Shirmardi

et al. 2015

J Radioanal Nucl Chem

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This study describes the preparation, biodistribution and absorbed dose prediction of 67 Ga and 99m Tc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67 Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99m Tc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67 Ga-BBN would result 2 times higher absorbed dose compare to 99m Tc-BBN.

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Section: Introductionmentioning

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Section: Measurement Of Activitymentioning

confidence: 99%

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Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

Shanehsazzadeh

Lahooti

Shirmardi

et al. 2015

J Radioanal Nucl Chem

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“…For each of these measurements, three samples (form each organ) were weighed and then counted by HPGe to determine the percentage of injected dose per gram [34]; all the organ activity measurements were normalized to injected activity. Uncertainties in the determinations were minimal, because each assay collected at least 10,000 counts, which results the standard deviation (SD) of\1 %.…”

Section: Measurement Of Activitymentioning

confidence: 99%

Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats

Nosrati

Shanehsazzadeh

Yousefnia

et al. 2015

J Radioanal Nucl Chem

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Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166 Ho-DTPA-SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166 Ho-DTPASPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15 % of injected dose was in liver and spleen at 30 min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166 Ho-DTPA-SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies.

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“…Recently, Ga-67-labeled ethylenecysteamine cysteine ( 67 Ga-ECC) has been reported [7] as a surrogate for developing a related Ga-68 complex. However, the assessment of the induced irradiation dose to human patients based on Ga-67 complex could impose the highest absorbed doses in the spleen and liver with 33.766 and 16.847 mGy, respectively [8], which in part can be due to Ga-67 rather than a long half life. Developing a homolog 68 Ga tracer not only provides the advantages of a PET tracer from the imaging point of view, but also a presents the possibility of in-clinic production of the tracer using an available Ga-68 generator.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of 68Ga-ECC as a PET Renal Imaging Agent

Mirzaei¹,

Jalilian²,

Aghanejad³

et al. 2015

Nucl Med Mol Imaging

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Purpose Development of a gallium-68-labeled renal tracer can be a good substitute for Tc-99m, a known SPECT tracer. In this study, effort was made to develop 6 8 Gaethylenecysteamine cysteine ( 68 Ga-ECC). Methods Ga-ECC was prepared using generator-based 68 GaCl 3 and ethylenecysteamine cysteine (ECC) at optimized conditions. Stability of the complex was checked in human serum followed by partition coefficient determination of the tracer. The biodistribution of the tracer in rats was studied using tissue counting and PET/CT imaging up to 120 min. Results Ga-ECC was prepared at optimized conditions in 15 min at 90°C (radiochemical purity ≈97±0.88 % ITLC, >99 % HPLC, specific activity: 210±5 GBq/mM).68 Ga-ECC was a water-soluble complex based on partition coefficient data (log P; −1.378) and was stable in the presence of human serum for 2 h at 37°C. The biodistribution of the tracer demonstrated high kidney excretion of the tracer in 10-20 min. The SUV max ratios of the liver to left kidney were 0.38 and 0.39 for 30 and 90 min, respectively, indicating high kidney uptake. Conclusion Initial biodistribution results showed significant kidney and urinary excretion of the tracer comparable to that of the homologous 99m Tc compound. The complex could be a possible PET kidney imaging agent with a fast imaging time.

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Assessment of human effective absorbed dose of 67 Ga–ECC based on biodistribution rat data

Abstract: The results show that this radiopharmaceutical can be a good SPECT tracer since it can be produced easily and also the absorbed dose in each organ is less than permitted absorbed dose.

Cited by 10 publications

References 16 publications

Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats

Preparation and Evaluation of 68Ga-ECC as a PET Renal Imaging Agent

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