Assessment of hormonal homeostasis in women with abnormal uterine bleeding and chronic stress

Fedosiuk, K.V.

doi:10.30841/2708-8731.9-10.2021.252587

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…2. Основну увагу серед зазначених вище патологій привернули ПМЦ як основна патологія, що, за даними різних авторів, може виникати на тлі стресу [20][21][22][23][24]. Тому жінки саме цієї групи були включені у дослідження з метою подальшого аналізу.…”

Section: матеріали та методиunclassified

Possibilities of treatment of stress-induced disorders of the menstrual cycle with phytotherapy

Kozub,

Hnatyuk

2024

RHW

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A woman’s reproductive system is one of the sensitive indicators of the female health. Its disorders indicate the development of any pathological process in the organism, which is often manifested by changes in specific functions. The impact of constant stress during the war on women who are in the frontline territories is becoming especially relevant today. In modern conditions, when psycho-emotional stress is a part of daily existence, it leads to the formation of pathologies that reduce the quality of life and fertility of a woman.The objective: to study the impact of stress on the female organism and the formation of stress-induced disorders of the menstrual cycle and to analyze the effect of phytotherapy in the complex treatment of such conditions in women.Materials and methods. 50 women of reproductive age (18–45 years old) with various forms of stress-induced menstrual cycle disorders, which developed during their stay in the front-line territories, were under observed. The patients were diagnosed with the following disorders of the menstrual cycle: absent of menstruation, light and infrequent menstruation, heavy, frequrnt and irregular menstrustions, pain and other contitions related to female sexual organs and menstrual cycle.All patients had clinical and laboratory, hormonal and instrumental examinations to determine the form of menstrual cycle disorder. Together with the basic therapy of the specified pathologies, all patients were prescribed a dietary supplement, which included a mixture of plant powder extracts: Vitex agnus-castus – 43,87 mg, Angelica sinensis – 43,87 mg, Filipendula vulgaris – 43,87 mg, Petroselinum crispum – 18,06 mg, Apium graveolens – 18,06 mg, Galium verum – 16,13 mg, Calendula officinalis – 16,13 mg, for 3 months, 2 capsules 2 times a day with with the aim of achieving hormone-correcting, sedative, analgesic, diuretic effects. Control clinical-hormonal and instrumental studies were conducted after 3 months.Results. During the study reduction of complaints was observeed (emotional lability – by 68%, periodic headache – by 36%, sleep disturbances – by 48%, anxiety – by 50%, fatigue – by 60%), as well as the normalization of the hormonal level – a decrease of prolactin concentration in 2 times, cortisol and follicle-stimulating hormone – 1.5 times, luteinizing hormone – 1.7 times, estradiol – 1.3 times, and an increase of progesterone level – in 7 times.A decrease or disappearance of clinical symptoms the menstrual cycle disorders, namely, a normalization of the frequency, duration and regularity of the menstrual cycle, a decrease in the amount of blood loss and manifestations of dysmenorrhea were determined.Conclusions. Phytotherapy, the composition of which contains a preparation with a blend of plant powder extracts: Vitex agnus-castus– 43,87 mg, Angelica sinensis – 43,87 mg, Filipendula vulgaris – 43,87 mg, Petroselinum crispum – 18,06 mg, Apium graveolens – 18,06 mg, Galium verum – 16,13 mg, Calendula officinalis – 16,13 mg, is effective in complex treatment of various forms of stress-induced menstrual cycle disorders.

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Section: матеріали та методиunclassified

Possibilities of treatment of stress-induced disorders of the menstrual cycle with phytotherapy

Kozub,

Hnatyuk

2024

RHW

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“…Останні роки відбуваються зміни у поглядах на етіологію, патогенез, класифікацію та лікування багатьох гінекологічних захворювань, а також на оцінювання своєчасності менархе та визначення нормальних показників менструального циклу у підлітковому та репродуктивному віці з огляду на стресогенні фактори війни в Україні [48,53].…”

Section: а к т у а л ь н і т е м иunclassified

Abnormal uterine bleeding in adolescents: modern views of the problem

Starovier,

Konkov,

Masibroda

2024

RHW

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The current analytical literature review examines modern views on the development of menstrual function, evaluation of the menstrual cycle, diagnosis, treatment and prevention of abnormal uterine bleeding (AUB) in adolescents, because this bleeding is the most common gynecological complaint in adolescent girls.The aim of this review was to identify differences in the diagnosis, monitoring and treatment of adolescent patients depending on the severity of menstrual bleeding. For this purpose, a literature search and analysis was conducted in the PubMed scientometric database for the past 20 years regarding the incidence, etiology, diagnosis, and clinical management of pubertal vaginal bleeding.AUB is a common problem that negatively affects a girl’s quality of life, and can also indicate the presence of a pathology that is forming or has already developed. The main cause of AUB in adolescence is anovulation, but pregnancy, bleeding from the rectum or urethra, the presence of a foreign body, trauma, and sexually transmitted diseases must also be excluded during the examination, regardless of history.It is ought to pay attention that it can be difficult for teenagers to visit a doctor or access services for problems related to the menstrual cycle. Therefore, pubertal bleeding requires not only a multidisciplinary and pro-proliferative approach, but also affordable management.Watchful waiting and observation are sufficient management options for mild AUB, but, on the other hand, life-threatening bleeding may require the use of high-dose combined oral contraceptives, progestins, intravenous estrogen, and/or interventional procedures.A thorough history and clinical examination to identify possible causes and associated risk factors can help identify causes of AUB that do not warrant further investigation and alternative diagnoses that require specific treatment and additional investigations. This review will be useful for clinicians to develop an optimal approach to the assessment and therapy of mild and severe AUB in puberty.

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Assessment of hormonal homeostasis in women with abnormal uterine bleeding and chronic stress

Cited by 2 publications

References 8 publications

Possibilities of treatment of stress-induced disorders of the menstrual cycle with phytotherapy

Possibilities of treatment of stress-induced disorders of the menstrual cycle with phytotherapy

Abnormal uterine bleeding in adolescents: modern views of the problem

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