Assessment of histopathological features of maculopapular viral exanthem and drug‐induced exanthem

Singh, Sanjay; Khandpur, Sujay; Arava, Sudheer; Rath, Rama Shankar; Ramam, M; Singh, Manoj Kumar; Sharma, Vinod; Kabra, SK

doi:10.1111/cup.13047

Cited by 19 publications

(32 citation statements)

References 16 publications

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“…Our report focuses on a COVID-19-related rash description and is supported by clinical images and histopathological examinations. Histological examination did not show any particular signs that can make this affection different from other rashes of viral aetiology except for extremely dilated vessels in the dermis which could represent a histological diagnostic finding 8 . It should be kept in mind that skin manifestations associated with this virus could present in any form and at any time during the natural history of the disease and we have no data demonstrating a direct correlation with the prognosis of this illness.…”

mentioning

confidence: 66%

Histological pattern in COVID‐19‐induced viral rash

Zengarini

Orioni

Cascavilla

et al. 2020

Acad Dermatol Venereol

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mentioning

confidence: 66%

Histological pattern in COVID‐19‐induced viral rash

Zengarini

Orioni

Cascavilla

et al. 2020

Acad Dermatol Venereol

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“…We did not evaluate the viral status of patients, but viral exanthem can clinically mimic drug exanthem [31].…”

Section: Limitation Of Our Researchmentioning

confidence: 99%

Hematologic Features of Children and Adolescent Patients with Acute Hypersensitivity Reactions on Drugs and Food

Eliseeva

Балаболкин

Геппе

et al. 2020

BioMed Research International

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Hematological parameters and blood biochemical markers were measured in 131 children and adolescent patients (70 boys) aged 2 to 17 years with acute hypersensitivity reactions induced by food (59 patients) and medicines (72 patients) in order to establish differences in clinical manifestations and hematological parameters in children with food and drug hypersensitivity and to elaborate the hematological criteria for differentiating the possible pathophysiological mechanisms of various types of hypersensitivity. Both groups of patients had comparable clinical symptoms with a predominance of skin lesions. The significant differences between the groups with drug- and food-induced hypersensitivity reactions were found in their red blood characteristics. In patients with hypersensitive reactions to drugs, significantly lower levels of erythrocytes and hemoglobin were found, while the median values of these parameters did not exceed the limits of reference values. These differences persisted also in the analysis of hemoglobin values, analyzed with accounting for the age and sex of patients. The reduction of hemoglobin was not accompanied by an increase in bilirubin in these patients. Thus, this fact does not support the assumption about the drug-induced hemolysis as a main effect influencing the hematological parameters. Hemogram evaluation performed during 7–10 days after admission demonstrated a higher level of hemoglobin in both groups. The biochemical markers were not significantly distinguished except bilirubin and alkaline phosphatase which were higher in patients with food-induced hypersensitivity.

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“…On laboratory evaluation, serum C reactive protein and absolute eosinophil count tend to be higher in morbilliform drug eruptions than virally induced skin eruptions, which might help in differentiating skin eruptions. 8 Physicians should be aware of typical presentation of morbilliform drug eruptions to differentiate from viral exanthems by the time course, associated symptoms and laboratory evaluation.…”

Section: Patient's Perspectivementioning

confidence: 99%