Assessment of Hepatitis B Viral Infection as a Predictor of Hepatic Enzymes and Compounds Alteration among Antenatal Patients

Abulude, Olatunji Ayodeji; Ismaila, Ahmed; Sadisu, Farouk Umar

doi:10.3390/medsci5040024

Cited by 13 publications

(15 citation statements)

References 20 publications

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“…The results of the current study are in line with Abulude et al . [ 17 ] study who found that seropositive patients to HBV showed elevation of ALT, AST, and ALP activities levels.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of canine hepatitis in stray dogs in Nineveh Province, Iraq

2020

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Aim: The current study was conducted to explore evidence of hepatitis B virus (HBV) infection in dogs in Nineveh Province, Iraq. Materials and Methods: Serum samples of 78 dogs were used to (i) estimate levels of the antibodies against HBV through enzyme-linked immunosorbent assay and (ii) measure the activity of liver function enzymes. Results: Seropositive dogs for HBV constituted 9% of total tested dogs. The differences in seropositivity among males compared to females and among different ages were not statistically significant. Liver function enzymes analysis revealed a significant increase in the activity of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase in seropositive dogs compared to those seronegative. Conclusion: Hepatitis B is evident in dogs in Nineveh Province, Iraq, with a significant impact on liver function in affected dogs. It is important to confirm this evidence through molecular tests.

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“…The results of the current study are in line with Abulude et al . [ 17 ] study who found that seropositive patients to HBV showed elevation of ALT, AST, and ALP activities levels.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of canine hepatitis in stray dogs in Nineveh Province, Iraq

2020

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“…This is well described by other authors confirming low specificity of serum albumin in differentiation between active and inactive state. 26 Serum albumin is synthesized in the liver only and therefore; a low level indicates marked hepatic impairment. 8 Our study showed that there was no association between TSB level and whether or not the patient has AH or IC.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of patients with HBeAg negative chronic hepatitis B virus infection in Duhok, Kurdistan region

Merza¹,

Yousif

Younus

et al. 2018

Int J Res Med Sci

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Background: The objective of this study was to characterize patients with HBeAg-negative chronic hepatitis B in Duhok province.Methods: We recruited all patients with HBeAg negative chronic hepatitis B virus infections who visited viral hepatitis clinic in Azadi Teaching Hospital between September 2015-December 2017. The main evaluation parameters were: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, serum albumin, total serum bilirubin (TSB), viral load. Few patients were subjected to Fibro-test, Fibroscan, or liver biopsy.Results: There were 251 patients. The mean age of the patients was 35.75±14.40 years. One hundred fifty-seven cases were male and 94 cases were female. The baseline mean of ALT, AST and viral load was 42.09±2.71U/L, 30.26±19.65U/L, and 1421197.08±14436692.04IU/ml, respectively. Compared with women, men have significantly higher values of ALT and AST, serum albumin, and TSB. There were 217 chronic inactive carrier (IC) patients and 34 chronic active hepatitis (AH) patients. ALT, AST, and viral load levels were significantly higher among AH patients.Conclusions: The majority of patients showed nil to mild liver injury. The higher level of ALT in males is a supporting guide to follow the American Association for the Study of Liver Diseases (AASLD) considering 30U/L and 19U/L levels for males and females, respectively. There was preponderance of males in AH, which indicates greater frequency of advanced fibrosis in such patients. There was a greater probability of AH in old aged people. Serum albumin and TSB were not good markers for differentiation between AH and IC state. Twenty-four patients had ALT above twice upper limit of normal level, but 34 patients showed AH based on liver biopsy, firboscan or fibrotest.

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“…e cause of deranged liver panel could not be ascertained for 22% (11/50) of the participants and alcoholism and hepatocellular carcinoma (HCC) were responsible for 8% (4/50) and 4% (2/50), respectively, of the cases (Table 1). Viral hepatitis has been associated with deranged liver panel in human studies, thus accounting for the majority of participants [20].…”

Section: Demographics and Aetiology Of Participants Livermentioning

confidence: 99%

Clinical Evaluation of the Safety and Effectiveness of Heptonica: A Ghanaian Hepatorestorative Polyherbal Product

Agyemang

Mensah

Yamile

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The incidence of liver diseases is increasing globally, and many patients in developing countries are resorting to the use of herbal products as treatment. This study was aimed at establishing the safety and effectiveness outcomes for patients with deranged liver panel treated with a Ghanaian finished polyherbal product. The product Heptonica is prepared by CPMR from three medicinal plants: Bidens pilosa, Citrus aurantifolia, and Trema orientalis. Fifty (50) participants with clinical and biochemical signs of liver impairment were purposively recruited and treated for a period of 28 days. Participants received Heptonica at a dose of 30 mL 8 hourly after meals for the treatment period. Clinical and biochemical evaluation (liver panel test, renal function test, haematology, and urinalysis) of subjects for the safety and effectiveness of the product was undertaken at days 0 (baseline), 14, and 28. Compared to the baseline values, Heptonica did not have any untoward effect on renal function, haematological parameters, and urine parameters of subjects. Clinical and liver panel results of the participants also improved compared to the baseline: serum aspartate transaminase (AST) (p < 0.0001), alanine transaminase (ALT) (p < 0.0001), gamma-glutamyltransferase (GGT) (p- 0.0013), total bilirubin (p-0.0136), direct bilirubin (p < 0.0001), total proteins (p-0.0409), and alkaline phosphates (p- 0.0284). Level of albumin showed no significant difference within the study period. The outcome of this study indicates Heptonica has hepatorestorative action with no observable toxicity and can be used with confidence as indicated as a liver tonic.

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Assessment of Hepatitis B Viral Infection as a Predictor of Hepatic Enzymes and Compounds Alteration among Antenatal Patients

Cited by 13 publications

References 20 publications

Seroprevalence of canine hepatitis in stray dogs in Nineveh Province, Iraq

Seroprevalence of canine hepatitis in stray dogs in Nineveh Province, Iraq

Characteristics of patients with HBeAg negative chronic hepatitis B virus infection in Duhok, Kurdistan region

Clinical Evaluation of the Safety and Effectiveness of Heptonica: A Ghanaian Hepatorestorative Polyherbal Product

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