Assessment of hepatic tissue blood flow with 133Xe clearance technique

Malinovsky, N.N.; Vinnitsky, L. I.; Zhidkov, I L

doi:10.1016/0047-0740(81)90055-3

Cited by 1 publication

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“…In particular, this latter route was used in the determination of blood flow in tissues lacking an artery easy to cannulate, as in skeletal muscle [15], s.c. tissue [29], experimental tumours [13]. As for the liver blood flow, in addition to the well-known intra-arterial [20,22,24] and intraportal [7,8,22,24] routes, also the interstitial one was employed in both man [9,23,33,39] and experimental animals [18]. Our choice is due to the fact that we aimed at measuring the blood flow in liver metastases, and no other administration route would have supplied this particular tissue with the tracer.…”

Section: Discussionmentioning

confidence: 99%

Blood flow of experimental liver metastases in rat as evaluated by the locally injected 133-Xenon washout

et al. 1985

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The investigations on blood flow in liver metastases are interesting from both a pathophysiological and a therapeutic point of view. Available data, however, are few and not definitive, as these studies are complex and difficult to perform. In a group of 25 Sprague-Dawley rats, in which liver metastases of Walker-256 carcinoma had been implanted, the blood flows in a metastasis and in the normal liver surrounding it were determined by means of the locally injected 133-Xenon washout. Thirteen sham-operated rats were a control group. Blood flow in the metastases was decreased as a group compared to that in the normal liver surrounding metastases and to that in liver of sham-operated rats. Small metastases showed normal or increased blood flow, large ones decreased or stagnant blood flow. Moreover, a significant inverse correlation was found between blood flow and diameter of metastasis. It is concluded that liver metastases of Walker-256 carcinoma show a decrease in blood flow which is related to the size of metastasis.

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