Assessment of Health-Related Quality of Life for Caregivers of Alzheimer’s Disease Patients

Andreakou, Maria I.; Papadopoulos, Angelos; Panagiotakos, Demosthenes B.; Niakas, Dimitris

doi:10.1155/2016/9213968

Cited by 33 publications

(31 citation statements)

References 39 publications

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“…Physical HRQoL also decreased as caregivers became older and mental HRQoL decreased as patient's CGA-NPI scores increased. Regarding the relationship between functional and psychological impairment and caregivers' HRQoL, several previous studies have shown consistent results with the present study 63031. However, there is controversy regarding the relationship between caregivers' HRQoL and demographic factors such as caregivers' age and sex 6.…”

Section: Discussionsupporting

confidence: 87%

Clinical and Demographic Predictors of Adverse Outcomes in Caregivers of Patients with Dementia

Lee

Choi

et al. 2019

Dement Neurocogn Disord

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Background and Purpose We aimed to elucidate independent predictors of adverse outcomes in caregivers of patients with dementia using readily available clinical and demographic data of patients with dementia and their caregivers. Methods We reviewed patient-caregiver data from the Clinical Research Center for Dementia of South Korea and Caregivers of Alzheimer Disease Research study. The clinical factors of the patients and the demographics of both patients and caregivers were used to predict adverse outcomes for caregivers. Correlation and linear regression analyses were performed. Results We enrolled 454 patients and their caregivers for the present study. The general burden for the caregiver was higher amongst female caregivers, patients with further decreased the level of activities of daily living (ADL), patients with more abnormal behavior, or younger patients. The time spent by the caregivers was more in cases of patients with higher Caregiver Administered Neuropsychiatric Inventory scores, younger patients and for patients with decreased level of ADL. Depression amongst caregivers was more prominent in patients with higher Clinical Dementia Rating Sum of Boxes scores. Physical health-related quality of life (HRQoL) was lower in female caregivers, more physically affected patients, and older caregivers. Lastly, mental HRQoL was lower in younger, more physically affected, and in patients with abnormal behaviors. Conclusions Clinical and demographic characteristics of patients and caregivers predict adverse outcomes for caregivers. Therefore, these factors should be considered to provide support to both patients and their caregivers.

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Section: Discussionsupporting

confidence: 87%

Clinical and Demographic Predictors of Adverse Outcomes in Caregivers of Patients with Dementia

Lee

Choi

et al. 2019

Dement Neurocogn Disord

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“…Nevertheless, besides mortality, depression indirectly affects the quality of life of the patients and their families [45, 46] and therefore must be detected and treated early on among patients with dementia.…”

Section: Discussionmentioning

confidence: 99%

Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia

Petersen

Waldorff

Siersma

et al. 2017

International Journal of Alzheimer's Disease

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Depression and dementia are commonly concurrent and are both associated with increased mortality among older people. However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality. We conducted a post hoc analysis based on data from the Danish Alzheimer's Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months. Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline. During the 3-year follow-up period, 56 patients died, and, among them, 12 were with MD-S at baseline. Multivariable analysis adjusting for the potential confounders (age, sex, smoking status, alcohol consumption, education, BMI, household status, MMSE, CCI, QoL-AD, NPIQ, ADSC-ADL, medication, and RCT allocation) showed that patients with MD-S had a 2.5-fold higher mortality as compared to the patients without or with only few depressive symptoms. Our result revealed that depression is possibly associated with increased mortality in patients with mild dementia. Given that depression is treatable, screening for depression and treatment of depression can be important already in the earliest stage of dementia to reduce mortality.

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“…The majority of caregivers in the current study, as in previously published works (Tang et al, 2013;Andreakou et al, 2016;Shim et al, 2016) were female daughters or wives living with individuals with dementia (Rodríguez et al, 2012;Andreakou et al, 2016).…”

Section: Discussionmentioning

confidence: 87%

Association between Physical Activity, General Health and Burden of Dementia Caregivers

Dimakopoulou

Sakka

Karydaki

et al. 2018

Journal of Sports Research

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Article HistoryKeywords Dementia Caregivers Physical activity Day care center Burden.Most caregivers do not engage in physical activity programs despite evidence that physical exercise improves general health and relieves symptoms of depression, anxiety and stress. The aim of the study is a) to investigate the amount of physical activity of caregivers in everyday life, b) to examine the reasons of limited participation in physical activities and c) to find out if limited participation in physical activity affects their general health. Fifty three (n=53) caregivers (59.04±12.76 yrs) were recruited by a Dementia Day Care Center. A caregiver questionnaire was designed to obtain information on basic demographics, living habits and current care details (hours of care, etc). The Greek version of PASE questionnaire was used to measure the amount of physical activity undertaken by caregivers. Caregiver burden was assessed via the Greek version of the validated Zarit burden interview and general health was investigated via the Greek version of General Health Questionnaire (GHQ-28). All data were analyzed by using SPSS, version 22. The majority of caregivers are daughters or wives. The current sample had a PASE mean score of 168.0±87.46. Differences in PASE score were found between occupational status (F=6.210, p=0.001) and living arrangements (F=3.882, p=0.05). No differences were found in PASE score between different levels of burden (F=1.058, p=0.376). PASE score was not related to GHQ28 scores. High correlations were found between ZBI and GHQ28 total (r=0.71, p=0.001) and ZBI and GHQ28 four subscales (somatic: r=0.62, p=0.001, anxiety-insomnia: r=0.66, p=0.001, social dysfunction: r=0.54, p=0.002, severe depression: r=0.44, p=0.003). ZBI was also correlated with years of care (r=0.38, p=0.004) and hours of care/day (r=0.40, p=0.003). The most frequent barriers to physical activity cited by caregivers were their living arrangements and their occupational status. In addition, burden was not cited as a significant barrier. Contribution/Originality:This study is one of very few studies which have investigated the amount of physical exercise of dementia caregivers and connects it with other important aspects of caregiving, as general health and their burden. Additionally, this paper explores the possible reasons that caregivers do not engage in physical exercise.

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Assessment of Health-Related Quality of Life for Caregivers of Alzheimer’s Disease Patients

Cited by 33 publications

References 39 publications

Clinical and Demographic Predictors of Adverse Outcomes in Caregivers of Patients with Dementia

Clinical and Demographic Predictors of Adverse Outcomes in Caregivers of Patients with Dementia

Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia

Association between Physical Activity, General Health and Burden of Dementia Caregivers

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