Assessment of health-related quality of life among patients with obesity, hypertension and type 2 diabetes mellitus and its relationship with multimorbidity

Abstract

Obesity, hypertension (HTN) and type 2 diabetes (T2D) are among the multifactorial disorders that occur at higher prevalence in a population. This study aims to assess the health-related quality of life (HRQoL) of patients with obesity, HTN and T2D individually and in the form of multimorbidity. A questionnaire-based cross-sectional study was conducted among the patients in 15 private clinics of Punjab, Pakistan. A stratified random sampling technique was used to collect the data from patients with obesity, HTN and T2D or their comorbidity. A total of 1350 patients responded by completing the questionnaire. The HRQoL of these patients was assessed using the EQ-5D-5L questionnaire (a standardized instrument for measuring generic health status). Statistical analysis was performed using chi-square test, Mann-Whitney U test, and Kruskal-Wallis test. Multivariate linear regression model was used to model the visual analogue scale (VAS) score. In total, 15% of patients had combined obesity, HTN and T2D; 16.5% had HTN and T2D; 13.5% had obesity and HTN and 12.8% had obesity and T2D. Only 15.8% of patients had obesity, 14.3% had HTN, and 12% had T2D. Mann Whitney-U test gave the statistically significant (p = <0.001) HRQoL VAS score55.1 (±23.2) of patients with the obesity. HRQoL VAS scores of patients with obesity were found to be higher when compared to patients with both T2D 49.8 (±15.4) and HTN 48.2 (±21). Diagnosis of one, two and three diseases showed significant results in VAS with all variables including gender (p = 0.004), educational level (p = <0.001), marital status (p<0.001), residence (p = <0.001), financial situation (p = <0.001) and monthly income (p = <0.001). The most frequently observed extremely problematic dimension was anxiety/ depression (47%) and the self-care (10%) was the least affected. Patient HRQoL is decreased by T2D, HTN, and obesity. The impact of these diseases coexisting is more detrimental to HRQoL.

Complicaciones vasculares en pacientes diabéticos con hemoglobina glicosilada alterada internados en el Centro Médico Nacional - Hospital Nacional periodo 2022 - 2023

“…Con relación a las comorbilidades asociadas, se ha encontrado una alta prevalencia de hipertensión arterial y obesidad en los pacientes estudiados. Hallazgos similares fueron reportados por Shah (16) , Fingeret (17) y Babu (18) en sus respectivos estudios, desarrollados en Pakistan, Inglaterra e India respectivamente. Es bien sabido que la obesidad, la hipertensión arterial y la diabetes tipo 2 son enfermedades crónicas que a menudo coexisten y se asocian con una morbilidad y mortalidad significativas en todo el mundo, en especial en la población con menores recursos económicos y poco acceso a servicios de salud de calidad.…”

Quality of Life of Patients with Hypertensive Disease and Type 2 Diabetes mellitus and Its Parameters Depending on Plasma Catestatin and Relaxin-2 Levels

“…Дослідження EXERDIET-HTA також продемонструвало нижчий рівень ЯЖ у пацієнтів з ГХ та ожирінням, зокрема фізичного функціонування, загального стану здоров'я, життєвої активності, соціального функціонування та психічного здоров'я, у той час як наявність у пацієнтів лише ожиріння супроводжується вищою ЯЖ порівняно із супутніми ГХ та ЦД-2 [22]. Вік, тривалість ЦД-2, тип гіпоглікемічної терапії, наявність ускладнень ЦД-2 та коморбідної патології та ІМТ впливають на ЯЖ пацієнтів з ЦД-2, зокрема на показники SF-36 [13].…”

Assessing the reliability and validity of the Slovenian version of the Appraisal of Diabetes Scale (ADS-S) in type 2 diabetes patients

“…Type 2 diabetes (T2D) is widely recognized as a significant public health problem due to its profound impact on individual well-being and healthcare costs [1]. It causes functional limitations and impairs overall quality of life, often leading to severe morbidity and premature death [1][2][3]. Despite medical advances, many patients still struggle to effectively manage crucial target values such as blood glucose (BG) levels and blood pressure [4][5][6].…”