Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry

Ricci, Camilla; Nyadong, Leonard; Yang, Felicia; Fernández, Facundo M.; Brown, Christopher D.; Newton, Paul N.; Kazarian, Sergei G.

doi:10.1016/j.aca.2008.06.007

Cited by 82 publications

(59 citation statements)

References 18 publications

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“…Substandard drugs can be detected by different methods, including inspection, colorimetric methods, chromatography, and spectrometry (Table 3) (9,12,31,43,45,(91)(92)(93)(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106). A three-level approach (107) consisting of different quality control procedures has been proposed to detect substandard/counterfeit antimicrobials.…”

Section: Methods Used To Detect Counterfeit/substandard Antimicrobialsmentioning

confidence: 99%

Substandard/Counterfeit Antimicrobial Drugs

2015

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SUMMARY Substandard/counterfeit antimicrobial drugs are a growing global problem. The most common substandard/counterfeit antimicrobials include beta-lactams (among antibiotics) and chloroquine and artemisin derivatives (among antimalarials). The most common type of substandard/counterfeit antimicrobial drugs have a reduced amount of the active drug, and the majority of them are manufactured in Southeast Asia and Africa. Counterfeit antimicrobial drugs may cause increased mortality and morbidity and pose a danger to patients. Here we review the literature with regard to the issue of substandard/counterfeit antimicrobials and describe the prevalence of this problem, the different types of substandard/counterfeit antimicrobial drugs, and the consequences for the individuals and global public health. Local, national, and international initiatives are required to combat this very important public health issue.

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Section: Methods Used To Detect Counterfeit/substandard Antimicrobialsmentioning

confidence: 99%

Substandard/Counterfeit Antimicrobial Drugs

2015

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“…1 These instruments are useful and advantageous, especially due to the low cost, simplicity of operation, convenience of fast in situ analysis and appropriate sensitivity and specificity to produce near realtime information used to solve specific problems which require rapid feedback of information. 2 Examples of portable instruments based on ion trap mass, 3 Raman, 4 near infrared 5 and mid-infrared 6 spectroscopies, capillary electrophoresis [7][8][9][10][11] and X-ray fluorescence 12 represent the tendency of instrument miniaturization for sensing applications. In case of miniature ion trap mass spectrometry, which represents a high breakthrough in portable analytical instrumentation, two approaches can be used to build this kind of instrument: the bottom-up approach in which the miniature instrument is assembled with the components built on a specific scale of interest; and the top-down approach, in which the component sizes of a macroscale instrument are reduced in an interactive way to maintain their performance.…”

Section: Introductionmentioning

confidence: 99%

A Low-Cost Video-Based Reflectometer for Selective Detection of Cu2+ Using Paper-Based Colorimetric Sensors

Morais

Silva

Pinheiro

et al. 2017

J. Braz. Chem. Soc.

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This paper presents a low-cost reflectometer for selective detection of Cu 2+ . The reflectometer is based on an emission light source using five light-emitting diodes at different wavelengths and a detector using a webcam. The samples were prepared using a filter paper-based colorimetric sensor with ascorbic acid-based quinoxaline derivative. Video analysis using gray color intensity was used to perform both copper ion screening ( ) and quantification of Cu 2+ in spiked samples. In addition, a multivariate validation was performed. The system proved to be selective to Cu 2+ among the screened ions, and its quantification was performed using partial least square regressions. Good linearity (R 2 = 0.979, coefficient of determination), low root-mean-square error of prediction (RMSEP = 5.20 × 10 -3 mol L -1 ) and high recovery (93.39-128.64%) were achieved. This method has potential to be employed for rapid and selective determination of Cu 2+ in water using low-cost instrumentation.

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“…This makes it attractive as a non-invasive technique that can be used for detection of counterfeit medicines, land mines and unexploded ordnances, or for screening baggage for explosives and narcotics at airports. For instance, the current commonly used counterfeit medicine detection technologies generally require varying degrees of sample pre-treatment or removal of pills from packages [7,8]. In contrast, portable NQR-based sensors can be developed that custom officers and other agents of law enforcement can use without having to remove the medicines from their packaging.…”

Section: Introductionmentioning

confidence: 99%

An Overview of NQR Signal Detection Algorithms

Butt

Gudmundson

Jakobsson

2013

NATO Science for Peace and Security Series B: Physics and Biophysics

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Nuclear quadrupole resonance (NQR) is a solid-state radio frequency spectroscopic technique that can be used to detect the presence of quadrupolar nuclei, that are prevalent in many narcotics, drugs, and explosive materials. Similar to other modern spectroscopic techniques, such as nuclear magnetic resonance, and Raman spectroscopy, NQR also relies heavily on statistical signal processing systems for decision making and information extraction. This chapter provides an overview of the current state-of-the-art algorithms for detection, estimation, and classification of NQR signals. More specifically, the problem of NQR-based detection of illicit materials is considered in detail. Several single-and multi-sensor algorithms are reviewed that possess many features of practical importance, including (a) robustness to uncertainties in the assumed spectral amplitudes, (b) exploitation of the polymorphous nature of relevant compounds to improve detection, (c) ability to quantify mixtures, and (d) efficient estimation and cancellation of background noise and radio frequency interference.The authors are at

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Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry

Cited by 82 publications

References 18 publications

Substandard/Counterfeit Antimicrobial Drugs

Substandard/Counterfeit Antimicrobial Drugs

A Low-Cost Video-Based Reflectometer for Selective Detection of Cu2+ Using Paper-Based Colorimetric Sensors

An Overview of NQR Signal Detection Algorithms

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