Assessment of halloysite nanotubes as vehicles of isoniazid

Carazo, E.; Borrego-Sánchez, Ana; García‐Villén, Fátima; Sánchez-Espejo, Rita; Aguzzi, Carola; Viseras, César; Sainz‐Díaz, C. Ignacio; Cerezo, Pilar

doi:10.1016/j.colsurfb.2017.09.036

Cited by 46 publications

(34 citation statements)

References 35 publications

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“…To avoid interactions between vicinal nanotubes, periodical cell parameters a = 50 Å, b = 50 Å were applied ( Figure 1). Then, a cylinder halloysite with an internal diameter of 27 Å was obtained with an external sheet of the tetrahedral siloxane and one internal sheet of Al oxide-hydroxide [18]. Although the internal diameter of a natural halloysite nanotube is around 15-50 nm, our model can be a good scenario to reproduce the interactions of the adsorption process at the molecular level.…”

Section: Methodology and Modelsmentioning

confidence: 99%

“…Halloysite nanotubes have been proposed as a natural vehicle for the dosage and modified release of several drugs. Halloysite nanotubes have been recently studied as nanocarriers for the controlled release of drugs [17,18]. Specifically, several experimental studies have been carried out to study the interaction between 5-ASA and halloysite nanotubes [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Molecular Modeling of Adsorption of 5-Aminosalicylic Acid in the Halloysite Nanotube

2018

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Abstract:Halloysite nanotubes are becoming interesting materials for drug delivery. The knowledge of surface interactions is important for optimizing this application. The aim of this work is to perform a computational study of the interaction between 5-aminosalicylic acid (5-ASA) drug and halloysite nanotubes for the development of modified drug delivery systems. The optimization of this nanotube and the adsorption of different conformers of the 5-ASA drug on the internal surface of halloysite in the presence and absence of water were performed using quantum mechanical calculations by using Density Functional Theory (DFT) and methods based on atomistic force fields for molecular modeling, respectively.

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Section: Methodology and Modelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Modeling of Adsorption of 5-Aminosalicylic Acid in the Halloysite Nanotube

2018

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“…Hybrid systems (INH‐loaded HLNTs) were prepared dispersing HLNTs powder (100 mg) in 20 mL of INH aqueous solution (0.25 M ) (initial drug/HLNTs ratio corresponding with the calculated monolayer adsorption capacity of the nanotubes), resulting in a drug content of 18.9 ± 0.12% w/w . Drug entrapment was calculated according both to the thermogravimetry results and by the experimental and theoretical adsorption data . A complete physicochemical characterization of raw materials (INH and HLNTs) and the resulting nanohybrid (INH‐loaded HLNTs) has been performed …”

Section: Methodsmentioning

confidence: 99%

“…The use of nanoparticles as vehicles for effective drug delivery in TB treatment have been proposed to increase drug bioavailability, protect from degradation and control release . A particular type of inorganic low cost nanoparticles is being proposed as potential excipients in the improvement of TB, and in particular some interesting hybrids have been recently designed . Halloysite is a two‐layered aluminosilicate chemically similar to kaolin, with prevailing hollow tubular structure in the nanometer range .…”

Section: Introductionmentioning

confidence: 99%

“…Essential features, as hollow tubular morphology and outer and inner surface charges, have made halloysite nanotubes (HLNTs) well documented carriers for encapsulation and release of drug molecules . In a previous work, it was shown that INH is spontaneously adsorbed by HLNTs, giving a self‐assembled and thermodynamic stable (Δ H = 70.40 kJ/mol; Δ S = 0.25 9 kJ/molK) nanohybrid (INH‐loaded HNLTs), in which drug molecules were adsorbed both onto the inner and at the outer surface of the nanotubes …”

Section: Introductionmentioning

confidence: 99%

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Halloysite nanotubes as tools to improve the actual challenge of fixed doses combinations in tuberculosis treatment

Carazo

Sandri

Cerezo

et al. 2019

J Biomedical Materials Res

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Halloysite nanotubes (HLNTs) were used as nanocarriers of the tuberculostatic agent isoniazid (INH), a BCS (Biopharmaceutics Classification System) class III drug. Self‐assembling nanohybrids (INH‐loaded HLNTs) with an average outer diameter of 90 nm and polydispersity index of 0.7 approximately, were obtained by spontaneous adsorption of INH molecules to HLNTs powder in aqueous medium. The nanohybrids were aimed to improve oral drug bioavailability and reduce physicochemical incompatibility of INH with other concomitantly administered tuberculostatic agents. In vitro drug release from INH‐loaded HLNTs was successfully fitted to a diffusive kinetic law founded on the adsorption–desorption equilibrium between drug molecules in solution and solid inorganic excipients. INH‐loaded HLNTs showed good in vitro biocompatibility toward Caco‐2 cells at the concentrations studied (up to 1233 μg/mL), with improved cell proliferation. Permeability tests showed that INH transport across Caco‐2 cellular membranes was greatly enhanced and fluorescent microscopy confirmed that the drug encapsulated into nanohybrid was effectively internalized by the cells. INH‐loaded HLNTs enhanced stability of the drug in presence of other tuberculostatic agents, both in binary and quaternary combinations. It has been demonstrated that simple interaction between INH with HLNTs leads to drug permeability and stability improvements that could greatly facilitate the design of multiple drug dosage forms, an actual challenge in oral treatment of tuberculosis. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Halloysite nanotubes: a green resource for materials and life sciences

Massaro

Lazzara

Noto

et al. 2020

Rend. Fis. Acc. Lincei

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Clay minerals are considered one of the materials of the 20th century for their peculiar physico-chemical features. Among them, halloysite nanotubes (HNTs) are an emerging nanomaterial with a particular tubular structure that makes them a low cost and valuable alternative to the most common carbon nanotubes. Due to their tubular morphology, HNTs are employed in several fields acting as nanocontainers for different compounds for applications in drug carrier and delivery fields, catalysis, and as filler for polymeric matrices. The modification of HNTs' surfaces allows to the synthesis of different nanoarchitectures that can improve the mechanical and thermal performance of polymer as well as they can enhance the use for the loading and release of chemicals. In this review, we summarize our recent results on halloysite functionalization, both supramolecular and covalent, and the application aforementioned fields.

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Assessment of halloysite nanotubes as vehicles of isoniazid

Cited by 46 publications

References 35 publications

Molecular Modeling of Adsorption of 5-Aminosalicylic Acid in the Halloysite Nanotube

Molecular Modeling of Adsorption of 5-Aminosalicylic Acid in the Halloysite Nanotube

Halloysite nanotubes as tools to improve the actual challenge of fixed doses combinations in tuberculosis treatment

Halloysite nanotubes: a green resource for materials and life sciences

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