Assessment of hair cortisol in euthyroid, hypothyroid, and subclinical hypothyroid subjects

Abdulateef, Darya Saeed; Mahwi, Taha Othman

doi:10.1007/s12020-018-1743-9

Cited by 9 publications

(16 citation statements)

References 56 publications

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“…Cortisol is secreted in a pulsating manner that is subject to circadian rhythms, and negative and positive feedback may depend on exogenous factors and numerous genetic variants determining the sensitivity of the cortisol receptor, which in turn, might alter its level and impact on clinical manifestations [6]. This may lead to misinterpretation of laboratory results and incorrect diagnosis [8,9]. Another problem raised by many other authors is the lack of sufficient validation of studies assessing the correlation of HCC with other biological samples [20,36,40].…”

Section: Discussionmentioning

confidence: 99%

“…Hence, non-primary HPArelated factors may influence the laboratory measurements. Oral contraception, pregnancy, or hyperthyroidism increase STC level (false positive results), while significant hypoalbuminaemia < 25 g/dL lowers STC concentration (false negative results) [5][6][7][8]. Serum free cortisol (SFC) measurement is not routinely performed.…”

Section: Introductionmentioning

confidence: 99%

“…However, determination of cortisol concentrations at night might be difficult for outpatient departments due to the working hours of laboratories. Serum cortisol is also assessed in dexamethasone suppression test, Synacthen stimulation test, corticotrophin releases hormone (CRH), or vasopressin stimulation tests used in the diagnosis and differentiation of cortisol level disorders [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva, and urine

Cieszyński

Jendrzejewski

Wiśniewski

et al. 2020

Endokrynologia Polska

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Introduction: Cortisol concentration is measured in blood, urine, and saliva samples. It has been recently proven that cortisol could also be detected in hair samples. Cortisol measurements in different samples have their own individual characteristics and clinical utility. We aimed to investigate the correlation between hair cortisol concentration and standard cortisol measurements used in clinical practice. Material and methods: Fifty adult volunteers with a negative history of endocrine disorders were enrolled in the study. Morning serum cortisol (MSC), evening serum cortisol (ESC), evening free salivary cortisol (EFSC), urine free cortisol (UFC), and hair cortisol concentration (HCC) were analysed in all participants. Eventually, 41 volunteers were included into the study, whose cortisol concentration in the 1 mg overnight dexamethasone suppression test (1 mg ONDST) were < 50 nmol/L, and cortisol levels in serum, saliva, and urine were within reference ranges. Hair cortisol concentration test was performed for 20 mg of hair strands of the proximal 1 cm hair segments. Results: Hair cortisol concentration ranged from 0.3036 to 2.65 nmol/L/mg, and the average value was 0.8125 ± 0.4834 nmol/L/mg. No significant correlations were found between HCC and MSC (rho = 0.04419, p = 0.7838), HCC and ESC (rho =-0.2071, p = 0.1938), HCC and EFSC (rho = 0.1005, p = 0.532), or HCC and UFC (rho = 0.1793, p = 0.262). Conclusions: This work is another step in the discussion on the application of HCC determinations in clinical practice. Our results have showed no correlations between HCC and single point cortisol assessment in blood, saliva, and urine in patients with reference cortisol levels.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva, and urine

Cieszyński

Jendrzejewski

Wiśniewski

et al. 2020

Endokrynologia Polska

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show abstract

“…Cortisol is secreted in a pulsating manner subject to circadian rhythms, negative and positive feedback may depend on exogenous factors, and numerous genetic variants determining the sensitivity of the cortisol receptor, which in turn, might alter its level and impact on clinical manifestations (4). This may lead to misinterpretation of laboratory results and wrong diagnosis (6,7). Another problem raised by many other authors is the lack of sufficient validation of studies assessing the correlation of HCC with other biological samples (18,34,38).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, non-primary HPA-related factors may influence the laboratory measurements. Oral contraception, pregnancy or hyperthyroidism increase STC level (false positive results), while significant hypoalbuminaemia < 25 g/dl lowers STC concentration (false negative results) (4)(5)(6). Serum free cortisol (SFC) measurement is not routinely performed.…”

Section: Introductionmentioning

confidence: 99%

Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva and urine.

Cieszyński

Jendrzejewski

Wiśniewski

et al. 2020

Preprint

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Background: Cortisol concentration is measured in blood, urine, and saliva samples. It has been recently proven that cortisol could be also detected in hair samples. Cortisol measurements in different samples have their own individual characteristics and clinical utility. We aimed to investigate the correlation between hair cortisol concentration and standard cortisol measurements used in clinical practice. Methods: Fifty adult volunteers with a negative history of endocrine disorders were enrolled into the study. Morning serum cortisol (MSC), evening serum cortisol (ESC), evening free salivary cortisol (EFSC), urine free cortisol (UFC) and hair cortisol were analyzed in all participants. Eventually, 41 volunteers were included into the study, whose cortisol concentration in the 1 mg overnight dexamethason suppression test (1mgONDST) were <50 nmol/l, and cortisol levels in serum, saliva and urine were within reference ranges. Hair cortisol concentration (HCC) was performed for 20 mg of hair strands of the proximal 1 cm hair segments. Results: HCC ranged from 0.3036 to 2.65 nmol/l/mg, and the average value was 0.8125±0.4834 nmol/l/mg. No significant correlations were found between HCC and MSC (rho=0.04419, p=0.7838), HCC and ESC (rho=-0.2071, p=0.1938), HCC and EFSC (rho=0.1005, p=0.532), and HCC and UFC (rho = 0.1793, p = 0.262). Conclusions : This work is another step in the discussion on the application of HCC determinations in clinical practice. Our results have showed no correlations between HCC and single point cortisol assessment in blood, saliva and urine in patients with reference cortisol levels. Keywords: Hair cortisol, Serum cortisol, Salivary cortisol, Urine cortisol, Cortisol assessment, Cortisol correlation

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Deciphering the Association Between Hypothalamus‐Pituitary‐Adrenal Axis Activity and Obesity: A Meta‐Analysis

Ostinelli

Scovronec

Iceta

et al. 2021

Obesity

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Objective Both the cortisol awakening response (CAR; corresponding to the state measurement) and hair cortisol concentration (HCC; corresponding to the trait measurement) are considered reliable markers of hypothalamus‐pituitary‐adrenal axis activity. Because cortisol has long been associated with adiposity, this systematic review and meta‐analysis aims to summarize and compare the literature around CAR and HCC and their association with obesity or fat distribution indices. Methods The PubMed, Web of Science (Web of Science Core Collection and Medline), EBSCO Information Services, Embase, and PsycNET databases were searched, and full‐text articles investigating the association between CAR or HCC and markers of adiposity in humans were included. Meta‐analyses were then performed to compare studies associating CAR or HCC with BMI (a marker of general adiposity) and waist circumference (a marker of fat distribution). Results The results of this review highlight inconsistencies in cortisol sampling and CAR computation, which makes comparisons between studies difficult. It was found that adiposity indices are not associated with CAR but that they correlate significantly and positively with HCC. The subgroup analysis hinted to possible age differences in the magnitude of the association between HCC and BMI. Conclusions Trait rather than state measurement of the hypothalamus‐pituitary‐adrenal axis activity is associated with increased general and abdominal adiposity in humans.

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Assessment of hair cortisol in euthyroid, hypothyroid, and subclinical hypothyroid subjects

Abstract: Overt hypothyroidism but not SCH is significantly associated with higher hair cortisol levels compared to normal subjects, and a significant relation between hair cortisol with HPT axis was found. Also, weight and BMI were positively correlated with hair cortisol level.

Cited by 9 publications

References 56 publications

Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva, and urine

Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva, and urine

Correlation analysis of cortisol concentration in hair versus concentrations in serum, saliva and urine.

Deciphering the Association Between Hypothalamus‐Pituitary‐Adrenal Axis Activity and Obesity: A Meta‐Analysis

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