Assessment of Haematological and Biochemical Effects of Kolaviron in Male Wistar Rats

Alabi, Quadri K.; Akomolafe, Rufus O.; Olukiran, Olaoluwa Sesan; Nafiu, Aliyat O.; Omole, Joseph Gbenga; Adefisayo, Adebukola; Oladele, Ayowole A.

doi:10.9734/bjpr/2017/33517

Cited by 16 publications

(12 citation statements)

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“…The increased body weight gain that was observed in KV-treated rats could be as a result of polyphagia caused by the stimulation of the feeding center in the hypothalamus. 36 Thus, KV was able to prevent the deleterious effect of CP on feeding pattern of rats in this study.…”

Section: Discussionmentioning

confidence: 51%

Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats

Omole

Ayoka

Alabi

et al. 2018

J Evid Based Complementary Altern Med

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Background.Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture of flavonoids, is reputed for its antioxidant and membrane stabilizing properties.Objective.This study investigated the protective effect of KV on CP-induced cardiotoxicity in rats.Methods.Thirty rats were used, and they were divided into 6 groups of 5 rats each. Group I received 2 mL/kg propylene glycol orally for 14 days; group II received CP (50 mg/kg/d, intraperitoneally [i.p.]) for 3 days; groups III and IV received 200 and 400 mg/kg/d KV, respectively, orally for 14 days and groups V and VI were pretreated with 200 and 400 mg/kg/d KV, respectively, orally for 14 days followed by CP (50 mg/kg/d, i.p.) for 3 days.Results.CP treatment resulted in a significantly lower food consumption and body weight in rats. The lactate dehydrogenase and creatine kinase enzymes in cardiac tissues of rats treated with CP were significantly higher. In cardiac tissues, 3-day doses of CP resulted in significantly higher heart weight, cardiac troponin I, myeloperoxidase, malondialdehyde, hydrogen peroxide and lower superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels. Histological examination of cardiac tissues showed sign of necrosis of myocardium after CP treatment. However, administration of KV at 200 and 400 mg/kg for 14 days prior to CP treatment, increase food consumption, body weight, and attenuates the biochemical and histological changes induced by CP.Conclusions.These results revealed that KV attenuates CP-induced cardiotoxicity by inhibiting oxidative stress and preserving the activity of antioxidant enzymes.

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Section: Discussionmentioning

confidence: 51%

Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats

Omole

Ayoka

Alabi

et al. 2018

J Evid Based Complementary Altern Med

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“…Decrease in red blood cell count (RBC) could reveal an imbalance between its production and loss [34]. The results obtained in this study revealed that AA induced colitis caused significant reduction in red blood cell counts (RBC) with subsequent decline in hemoglobin (HB) concentration.…”

Section: Discussionmentioning

confidence: 68%

The aqueous extract ofOcimum gratissimumleaves ameliorates acetic acid-induced colitis via improving antioxidant status and hematological parameters in male Wistar rats

Olamilosoye

Akomolafe

et al. 2018

Egyptian Journal of Basic and Applied Sciences

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The beneficial effects of Ocimum gratissimum, have been attributed mainly to its antioxidant and antiinflammatory properties. This study investigated the protective effects of aqueous extract of Ocimum gratissimum leaves (AEOGL) on acetic acid induced colitis in male rats. Twenty male Wistar rats, 100-180 g were divided into four groups as follows: Group 1 (control) (n = 5) received 2 ml/kg of distilled water for 21 consecutive days. Group 2 (n = 5) received 2 ml of 6% acetic acid solution once intra rectally for induction of colitis. Group 3 and 4 (n = 5 each) were treated as group 2 and thereafter received AEOGL orally at 200 and 400 mg/kg/day respectively for 20 consecutive days. All the animals from each group were sacrificed 24 h after the induction of colitis and administration of AEOGL. The diarrhea score, ulcer score, hematological parameters, nitric oxide (NO), myeloperoxidase (MPO), superoxide dismutase (SOD), reduced glutathione (GSH) markers and histopathological alteration were evaluated. Acetic acid-induced colitis significantly caused alteration in diarrhea score, ulcer score, hematological parameters, MPO and SOD activities, NO and GSH levels (p < 0.05). It induced significant inflammation of the colonic tissue. AEOGL administration significantly decreased diarrhea score and ulcer score to normal (p < 0.05). It prevented alteration effect of acetic acid on hematological parameters and significant decreases the activities of MPO, SOD, NO and increase GSH levels (p < 0.05) in colitis rats. In conclusion, Ocimum gratissimum leaves possesses ameliorative effects against acetic acid-induced colitis as a consequence of its antiinflammatory and anti-oxidative properties.

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“…The deviation from normal haematological parameters levels represents the presence of toxicity or disease conditions [19]. The decrease in red blood cell count (RBC) level could be a result of an imbalance between its production and loss [20]. In this study, codeine administration caused a significant reduction in red blood cell counts (RBC).…”

Section: Discussionmentioning

confidence: 78%

“…Twenty (20) male wistar strain albino rats were divided into four groups of five rats each according to their weight. Group I labelled control received saline solution for 28 days through the oral route.…”

Section: Experimental Designmentioning

confidence: 99%

Codeine-mediated Haematoxicity, Hepatotoxicity and Nephrotoxicity in Male Albino Rats

Owoade

Abdullateef

Adetutu

et al. 2019

AJRIMPS

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Objectives: This study aimed to investigate the effects of codeine administration on some haematological and biochemical indices in rats. Materials and Methods: Therapeutic dose (5 mg/kg/day), high dose (25 mg/kg/day) and extreme dose (50 mg/kg/day) of codeine were administered orally to rats for 28 days. Twenty-four hours after the last codeine administration, blood, liver and kidney were removed from the animals after an overnight fast and analysed for their haematological and biochemical parameters. Results: Results obtained revealed that codeine administration significantly reduced the levels of white blood cells (WBC), red blood cell (RBC) and platelet count (PLT) and increased the levels of mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV)while it resulted in non-significant changes in other haematological parameters examined when compared with control rats. Codeine intake significantly increased plasma levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST), creatinine and urea while its reduced total protein levels. Hepatic and renal thiobarbituric acid reactive substances (TBARS) levels were significantly increased by codeine administration while levels of endogenous antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were reduced. Conclusions: This study confirmed the risk of increased oxidative stress, haematoxicity, hepatotoxicity and nephrotoxicity due to codeine administration. Although codeine is reported to be effective in pain management, its toxicity should be kept in mind.

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Assessment of Haematological and Biochemical Effects of Kolaviron in Male Wistar Rats

Cited by 16 publications

References 0 publications

Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats

Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats

The aqueous extract ofOcimum gratissimumleaves ameliorates acetic acid-induced colitis via improving antioxidant status and hematological parameters in male Wistar rats

Codeine-mediated Haematoxicity, Hepatotoxicity and Nephrotoxicity in Male Albino Rats

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