“…It was found that the antivirals nevirapine, efavirenz, and the psychiatric drug carbamazepine, always occurred around 2-13 ng/L in different samples withdrawn from the Dam Hartbeespoort, Gauteng province, over the year It emerges that the most frequently monitored classes were antibiotics (372 values), analgesics and anti-inflammatories (347 values), psychiatric drugs (155 values), and antivirals (154 values). It was found that concentrations of pharmaceuticals may be very high in surface water: this occurs for acetylsalicylic acid (159,900 ng/L, [48]), ibuprofen (84,600 ng/L, [49]), clozapine (78,300 ng/L, [48]), phenacetin (68,300 ng/L, [40]), estriol (46,200 ng/L, [54]), caffeine (33,200 ng/L, [49]) and atenolol (30,000 ng/L, [24]). Most investigations noted that higher concentrations were found in winter than in summer depending on the typical consumption pattern.…”