Assessment of groundwater contamination from a hazardous dump site in Ranipet, Tamil Nadu, India

Rao, G. Tamma; Rao, V. V. S. Gurunadha; Ranganathan, K.; Surinaidu, L.; Mahesh, J.; Ramesh, G.

doi:10.1007/s10040-011-0771-9

Cited by 48 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The granitic formation in the northern part of Palar River catchment has the high infiltration rates and results in fast migration of the contamination to the water table. The Chromium levels in groundwater of these areas were found up to 275 mg L −1 as reported by (Rao et al, 2011). Taking the Paler River catchment into consideration to access the genotoxic effects of major Indian carp Catla catla is chosen for our study.…”

Section: Introductionmentioning

confidence: 96%

IN-VIVO EVALUATION OF HEXAVALENT CHROMIUM INDUCED DNA DAMAGE BY ALKALINE COMET ASSAY AND OXIDATIVE STRESS IN CATLA CATLA

Arunachalam

Annamalai

Kuruva

2013

American Journal of Environmental Sciences

View full text Add to dashboard Cite

In the present study, the acute toxicity of Chromium in fingerlings of Catla catla, an Indian major carp, was evaluated with renewal bioassay method. In vivo studies were designed to assess the extent of Micronucleus Assay, Comet Assay under the exposure of common heavy-metal compounds, namely, Chromium Nitrate, using Catla catla (2n = 20), as a test model. The laboratory acclimatized fishes were divided into four groups. Group I served as positive control and the other three as exposed groups for three different time durations of 7, 14 and 21 days and were subjected to uninterrupted sub lethal concentrations (50% of 96 h LC 50 ). The experiments were planned in such a way that fish from all the groups were sacrificed on the same day. The frequencies of micronuclei and bi-nuclei were evaluated comparatively in peripheral erythrocytes. As a result, it was observed that, the fishes and different tissues showed differential sensitivity to the heavy-metal treatment. A significant increase in the frequencies of micronucleated and binucleated cells and percentage increase in DNA tail (p<0.001) through Alkaline Comet Assay were observed after 21 days of exposure to chromium. Our results also showed decrease in enzyme Superoxide Dismutase (SOD) activity and increase in catalase enzyme due to increasing chromium concentration. The bio-concentration factor profiles of Chromium in Catla catla during sub lethal toxicity study was also calculated.

show abstract

Section: Introductionmentioning

confidence: 96%

IN-VIVO EVALUATION OF HEXAVALENT CHROMIUM INDUCED DNA DAMAGE BY ALKALINE COMET ASSAY AND OXIDATIVE STRESS IN CATLA CATLA

Arunachalam

Annamalai

Kuruva

2013

American Journal of Environmental Sciences

View full text Add to dashboard Cite

show abstract

“…Whereas the drinking water or the ground water levels of Cr in some of the worst pollution incidents in the US and developing countries have been over 50–500 times the EPA limit ( e.g. , Midland, TX, the US (5.28 ppm) (Malott, 2015), Hinkley, CA (5.0 ppm) (ContaminatedRealty, 2015), Leon, Mexico (50 ppm) (Armienta-Hernández and Rodríguez-Castillo, 1995), China (Zhang and Li, 1987) and India (31–50 ppm) (Dubey et al, 2001; Rao et al, 2011). Occupational exposure to Cr is found among approximately half a million industrial workers in the US and several millions worldwide.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol

Banu

Stanley

Sivakumar

et al. 2016

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Resveratrol (RVT), a polyphenolic component in grapes and red wine, has been known for its cytoprotective actions against several diseases. However, beneficial effects of RVT against early exposure to endocrine disrupting chemicals (EDCs) have not been understood. EDCs are linked to several ovarian diseases such as premature ovarian failure, polycystic ovary syndrome, early menopause and infertility in women. Hexavalent chromium (CrVI) is a heavy metal EDC, and widely used in >50 industries. Environmental contamination with CrVI in the US is rapidly increasing, predisposing the human to several illnesses including cancers and still birth. Our lab has been involved in determining the molecular mechanism of CrVI-induced female infertility and intervention strategies to mitigate CrVI effects. Lactating mother rats were exposed to CrVI (50 ppm potassium dichromate) from postpartum days 1–21 through drinking water with or without RVT (10 mg/kg body wt., through oral gavage daily). During this time, F1 females received respective treatments through mother’s milk. On postnatal day (PND) 25, blood and the ovary, kidney and liver were collected from the F1 females for analyses. CrVI increased atresia of follicles by increasing cytochrome C and cleaved caspase-3; decreasing antiapoptotic proteins; decreasing estradiol (E2) biosynthesis and enhancing metabolic clearance of E2, increasing oxidative stress and decreasing endogenous antioxidants. RVT mitigated the effects of CrVI by upregulating cell survival proteins and AOXs; and restored E2 levels by inhibiting hydroxylation, glucuronidation and sulphation of E2. This is the first study to report the protective effects of RVT against any toxicant in the ovary.

show abstract

“…This study showed that exposure of pregnant rats to CrVI (50 ppm) through drinking water from 9.5 to 14.5 dpc reduced fetal weight. The dose of CrVI used in the study is environmentally relevant to some of the worst polluted places of the world such as India (Dubey et al, 2001b;Rao et al, 2011), Mexico (Armienta-Hern andez and Rodr ıguez-Castillo, 1995), China (Zhang and Li, 1987), and Bangladesh (Frisbie et al, 2002). Moreover, the pregnancy window of 9.5-14.5 dpc is the active period for TCs proliferation (Jollie, 1964).…”

Section: Discussionmentioning

confidence: 99%

“…In vivo dosing and experimental design. The in vivo CrVI dosing used in this investigation was chosen based on Cr levels in drinking water in highly polluted regions in developing countries that range from 19-50 ppm (Armienta-Hernandez and Rodr ıguez-Castillo, 1995; Dubey et al, 2001a;Rao et al, 2011;Sharma et al, 2012). The pregnancy dating system was determined as follows: Fertility-proven normal male rats were cohabited with female rats in the evening.…”

mentioning

confidence: 99%

Editor’s Highlight: Exposure to CrVI during Early Pregnancy Increases Oxidative Stress and Disrupts the Expression of Antioxidant Proteins in Placental Compartments

et al. 2016

View full text Add to dashboard Cite

Epidemiologic studies document relationships between chromium VI (CrVI) exposure and increased risk of spontaneous abortion, stillbirth, preterm birth, and neonatal death in pregnant women. Environmental contamination with CrVI is a growing problem both in the United States and developing countries. CrVI is widely used in numerous industries. This study was designed to understand the mechanism of CrVI toxicity on placental oxidative stress and antioxidant (AOX) machinery. Pregnant mother rats were treated with or without CrVI (50 ppm K 2 Cr 2 O 7 ) through drinking water from gestational day (GD) 9.5-14.5, and placentas were analyzed on GD 18.5. Results indicated that CrVI reduced the trophoblast cell population. CrVI increased reactive oxygen species (ROS) and decreased the expression of AOX proteins. CrVI disrupts the trophoblast proliferation of the placenta. This study provides insight into the critical role of AOXs in placental function.

show abstract

Assessment of groundwater contamination from a hazardous dump site in Ranipet, Tamil Nadu, India

Cited by 48 publications

References 13 publications

<i>IN-VIVO</i> EVALUATION OF HEXAVALENT CHROMIUM INDUCED DNA DAMAGE BY ALKALINE COMET ASSAY AND OXIDATIVE STRESS IN <i>CATLA CATLA</i>

<i>IN-VIVO</i> EVALUATION OF HEXAVALENT CHROMIUM INDUCED DNA DAMAGE BY ALKALINE COMET ASSAY AND OXIDATIVE STRESS IN <i>CATLA CATLA</i>

Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol

Editor’s Highlight: Exposure to CrVI during Early Pregnancy Increases Oxidative Stress and Disrupts the Expression of Antioxidant Proteins in Placental Compartments

Contact Info

Product

Resources

About