Assessment of gross examination and frozen section of uterine specimen in endometrial cancer patients

Ghaemmaghami, Fatemeh; Aminimoghaddam, Soheila; Modaresgilani, Mitra; Mousavi, Azam Sadat; Khazaeipour, Zahra; Fereidoni, Forozandeh

doi:10.1007/s00404-010-1387-3

Cited by 11 publications

(13 citation statements)

References 15 publications

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“…Poor prognostic factor in stage I endometrial adenocarcinoma consist of tumor grade, depth of myometrial invasion, lymphovascular involvement, and histological subdivision (5). Although the stage of malignancy has the main role in the prediction of the disease outcome, other factors can be indirectly affect the survival rate (12). Progression in clinical management of early stage endometrial cancers requires more predictive prognostic biomarkers to prevent 10% to 20% recurrence in such cases (2).…”

Section: Introductionmentioning

confidence: 99%

Investigating the Association of Lower Uterine Segment Involvement with Deep Myometrial Invasion in Endometrial Adenocarcinoma

Aminimoghaddam

Kamyabi

Yarandi

et al. 2017

J Obstet Gynecol Cancer Res

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Background: Endometrial carcinoma is the most common cancer of the female genitalia and its prevalence is 2% to 3% along the females' lifetime. This adenocarcinoma is diagnosed in the early stages because the patients become symptomatic early in the course of disease. The correlation of the lower uterine segment involvement (LUSI) with the recurrence, and the survival rates in patients with endometrial adenocarcinoma are always questionable. Confirming the prognostic significance of LUSI can fundamentally improve the current state of patients' surveillance. The current study aimed at investigating the association of lower uterine segment involvement with deep myometrial invasion in endometrial adenocarcinoma. Methods: In the current retrospective cohort study, 54 patients with stage I endometrial endometrioid adenocarcinoma who underwent surgery in Mirza-Koochak-Khan Hospital, Tehran, Iran, from 2004 to 2014 were divided into 2 groups according to the presence of LUSI. In the current cohort study, the data from the patients exposed to LUSI were obtained by questionnaires to measure deep myometrial invasion besides post-operative adjuvant radiotherapy. The median of follow-up period was 48 months for all of the patients, which started after their surgery, and the measurement period for variables were similar to those of the follow-up period, which was 48 months. They were compared regarding to age, tumor grade, depth of myometrial invasion, lymphovascular involvement, extra uterine diseases, the extent of lymphadenectomy, adjuvant therapy, recurrence rate, time, and location. The data analysis was conducted by the SPSS v.16 statistical software (Chicago, IL, USA) at the significance level of 5%. In the investigation, Chi-square, the Kolmogorov-Smirnov, t test, and the Mann-Whitney U tests were used. Results: Group 1 consisted of 13 patients with LUSI and group 2 had 41 patients without LUSI divided by a non-random sampling method. According to the results of the Mann-Whitney U test, there was a significant difference between the mean age of patients with LUSI and that of the ones without LUSI (P = 0.03). It showed that the mean age in the former group was significantly higher than that of the latter. A Chi-square test showed no significant association between the lymphovascular involvement and the presence of LUSI (P = 0.1). The Fisher exact test showed that patients with LUSI had significantly higher rate of radiotherapy after surgery rather than the ones without LUSI (P < 0.001). Conclusions: In conclusion, there was a significant association between the lower uterine segment involvements with deep myometrial invasion in the endometrial endometrioid adenocarcinoma. In other words, there was a significant difference in the depth of myometrial invasion between the groups, and the patients with LUSI had deeper myometrial invasion (the Mann-Whitney U test, P < 0.001).

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Section: Introductionmentioning

confidence: 99%

Investigating the Association of Lower Uterine Segment Involvement with Deep Myometrial Invasion in Endometrial Adenocarcinoma

Aminimoghaddam

Kamyabi

Yarandi

et al. 2017

J Obstet Gynecol Cancer Res

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“…The main controversial issue of treatment concerns the therapeutic role of lymphadenectomy. In many centers, gynecological oncologist surgeons make a decision on whether to perform lymph‐node dissection based on macroscopic intraoperative evaluation of the degree of myometrial infiltration. A recent meta‐analysis has shown that pooled sensitivity and specificity for this approach was 75% and 95%, respectively, when using definitive histopathological diagnosis as reference standard.…”

Section: Introductionmentioning

confidence: 99%

Agreement between preoperative transvaginal ultrasound and intraoperative macroscopic examination for assessing myometrial infiltration in low‐risk endometrioid carcinoma

Pineda

Alcázar

Caparrós

et al. 2016

Ultrasound in Obstet & Gyne

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“…At least one year of OCP use is associated with a 50% decline in the risk of cancer; this protection is maximized by 3 years of OCP use (the effects persist for 20 -30 years) (23). The protective properties of OCPs affect 3 types of endometrial cancers, ie, endometrioid carcinoma, clear cell endometrial cancer, and papillary serous endometrial cancer (24,25).…”

Section: Resultsmentioning

confidence: 99%

“…The risk of epithelial ovarian cancer reduces by 40% in OCP consumers, and optimal effects can be obtained by 3 years of consumption; however, the risk reduces within 3 to 6 months of OCP consumption (25). This protective effect is especially evident in nulliparous women, breast cancer (BRCA) gene I and II carriers, and those with a positive family history.…”

Section: Resultsmentioning

confidence: 99%

A Review of Recent Findings for Obstetricians about Combined Oral Contraceptive Pills

Aminimoghaddam

2017

J Obstet Gynecol Cancer Res

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Combined oral contraceptive pills (OCPs) contain estrogen (ethinylestradiol) and progesterone (first-generation levonorgestrel and fourthgeneration drospirenone). Progesterone has peripheral effects on the endometrium, fallopian tubes, and cervix and can promote contraception. These pills are used to prevent pain caused by Mittelschmerz syndrome and endometriosis and to treat hyperandrogenism. To prescribe contraceptives, it is adequate to take the patient's medical history and blood pressure. In the absence of risk factors, patients should be followed-up by history-taking, blood pressure measurement, urinalysis, Pap smear test, and examination of breasts, pelvis, and liver. The risk of venous thrombosis in new OCPs is twice higher than that of older generations and usually occurs in the first year of consumption. The only absolute contraindications for the use of new OCPs include chronic and acute cholestatic liver diseases. In fact, use of new OCPs increases the risk of liver adenoma, but not hepatocellular carcinoma. On the other hand, in female patients with genital tract cancers, risk of endometrial and ovarian epithelial cancers decreases following the use of OCPs. However, the risk of cervical adenocarcinoma increases after 5 years of consumption due to cervical eversion and impaired vitamin metabolism. These pills are contraindicated in women above 35 years who smoke more than 15 cigarettes daily or have uncontrolled hypertension, venous thromboembolism, migraine aura, severe hyperglycemia, breast cancer (diagnosed or suspected), or diabetes mellitus associated with cardiovascular diseases.

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Assessment of gross examination and frozen section of uterine specimen in endometrial cancer patients

Abstract: These data confirm the previous reports for the accuracy of gross examination and frozen section diagnosis in early stage and low-grade tumors.

Cited by 11 publications

References 15 publications

Investigating the Association of Lower Uterine Segment Involvement with Deep Myometrial Invasion in Endometrial Adenocarcinoma

Investigating the Association of Lower Uterine Segment Involvement with Deep Myometrial Invasion in Endometrial Adenocarcinoma

Agreement between preoperative transvaginal ultrasound and intraoperative macroscopic examination for assessing myometrial infiltration in low‐risk endometrioid carcinoma

A Review of Recent Findings for Obstetricians about Combined Oral Contraceptive Pills

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