Assessment of glioma response to radiotherapy using 3D pulsed-continuous arterial spin labeling and 3D segmented volume

Wang, Peng; Li, Jianrui; Quan-ping, Diao; Lin, Yinyao; Zhang, Jun; Lin, Li; Yang, Gang; Fang, Xiaokun; Xie, Lihua; Chen, YingQi; Zheng, Luming; Lu, Guangming

doi:10.1016/j.ejrad.2016.08.009

Cited by 13 publications

(9 citation statements)

References 26 publications

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“…ASL has also been deployed extensively in neuro-oncology, both to aid diagnosis 177,178 and therapy monitoring, 179 and to assist pre-surgical planning. 180 Higher grade tumours tend to show higher perfusion and vascularity, and ASL is also able to help distinguish tumourous progression from contrast-enhancing mimics and radiation necrosis.…”

Section: Applications Of Aslmentioning

confidence: 99%

Arterial spin labeling for the measurement of cerebral perfusion and angiography

Jezzard

Chappell

Okell

2017

J Cereb Blood Flow Metab

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Arterial spin labeling (ASL) is an MRI technique that was first proposed a quarter of a century ago. It offers the prospect of non-invasive quantitative measurement of cerebral perfusion, making it potentially very useful for research and clinical studies, particularly where multiple longitudinal measurements are required. However, it has suffered from a number of challenges, including a relatively low signal-to-noise ratio, and a confusing number of sequence variants, thus hindering its clinical uptake. Recently, however, there has been a consensus adoption of an accepted acquisition and analysis framework for ASL, and thus a better penetration onto clinical MRI scanners. Here, we review the basic concepts in ASL and describe the current state-of-the-art acquisition and analysis approaches, and the versatility of the method to perform both quantitative cerebral perfusion measurement, along with quantitative cerebral angiographic measurement.

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Section: Applications Of Aslmentioning

confidence: 99%

Arterial spin labeling for the measurement of cerebral perfusion and angiography

Jezzard

Chappell

Okell

2017

J Cereb Blood Flow Metab

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“… HC No Nudelman [ 56 ] 3T 27/27F (50 ± 8) Breast I–III RTx 2, DXR 11, CP,DTX, HTx 3 PASL CBF↑ 7–12% after 1 m vs CTx- and HC group; CBF↑ 35% in CTx + , CBF↑ 13% in CTx- both in precentral gyrus vs HC 26/26F (52 ± 9) Breast 0–II RTx 6, HTx 26/26F (48 ± 10) HC No Nudelman [ 57 ] 3T 24/24F (49 ± 8) Breast I–III RTx 2, DXR 11, CP, DTX, HTx PASL CBF↑ after 1 m and 12 m in CTx + vs T0 23/23F (59 ± 9) Breast 0–II HTx Petr [ 140 ] 3T 24/? (54 ± 14) GBM IV IMRTx 60 Gy, TMZ 75 mg/m2 pCASL CBF↓ 9.8% in GM after 3 and 6 m vs T0 Petr [ 9 ] 3T 44/20F (55 ± 13) GBM IV RTx 60 Gy, TMZ 75 mg/m2 pCASL CBF↓ 10–11% in GM after 3 and 6 m, proton and photon therapy comparable ↓ vs T0 16/5F (52 ± 16) Proton 60 Gy, TMZ 75 mg/m2 Wang [ 52 ] 3T 16/? (65 ± 9) LGG I–II RTx 36-63 Gy pCASL CBF↓ 7–18% after 2-4 m vs T0 19/?…”

Section: Resultsmentioning

confidence: 99%

“…ASL did not show CBF changes in NABT at 3 months after SRS in brain metastases patients [ 42 ], and unclear findings of both increase and decrease were reported in patients diagnosed with high-grade (HGG) and low-grade gliomas (LGG), respectively [ 52 ]. A larger prospective study in glioblastoma patients was, however, in line with the majority of DSC results showing 10–11% CBF decrease 3 and 6 months after photon RCTx at both low and high-dose regions, with a comparable decrease seen in proton-therapy patients alone [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

Petr

Hogeboom

Nikulin

et al. 2021

Magn Reson Mater Phy

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Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural changes appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking these treatment side effects into account, paving the way towards a more personalized treatment planning.This systematic review (PROSPERO number 224196) provides an overview of quantitative tomographic imaging methods, potentially identifying the adverse side effects of cancer therapy in normal-appearing brain tissue. Seventy studies were obtained from the MEDLINE and Web of Science databases. Studies reporting changes in normal-appearing brain tissue using MRI, PET, or SPECT quantitative biomarkers, related to radio-, chemo-, immuno-, or hormone therapy for any kind of solid, cystic, or liquid tumor were included. The main findings of the reviewed studies were summarized, providing also the risk of bias of each study assessed using a modified QUADAS-2 tool. For each imaging method, this review provides the methodological background, and the benefits and shortcomings of each method from the imaging perspective. Finally, a set of recommendations is proposed to support future research.

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“…The MRI presentations of PsP and RT are similar, yet these 2 lesion types exhibit distinct angiogenesis characteristics. 35 Dynamic susceptibility contrast-enhanced PWI reflects blood perfusion and tissue microvessel distributions. Although RT lesions exhibit characteristics consistent with immature vascular structures, dense neovasculature, and increased vascular endothelial growth factor expression, PsP lesions instead exhibit hypoperfusion resulting from vascular endothelial cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted Imaging in Differentiation Between Recurrence and Pseudoprogression in High-Grade Glioma: A Meta-analysis

Gu,

He,

Wang

et al. 2023

J Comput Assist Tomogr

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Introduction In glioma patients that have undergone surgical tumor resection, the ability to reliably distinguish between pseudoprogression (PsP) and a recurrent tumor (RT) is of key clinical importance. Accordingly, this meta-analysis evaluated the utility of dynamic susceptibility contrast-enhanced perfusion-weighted imaging as a means of distinguishing between PsP and RT when analyzing patients with high-grade glioma. Materials and Methods The PubMed, Web of Science, and Wanfang databases were searched for relevant studies. Pooled analyses of sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) values were conducted, after which the area under the curve (AUC) for summary receiver operating characteristic curves was computed. Results This meta-analysis ultimately included 21 studies enrolling 879 patients with 888 lesions. Cerebral blood volume–associated diagnostic results were reported in 20 of the analyzed studies, and the respective pooled sensitivity, specificity, PLR, and NLR values were 86% (95% confidence interval [CI], 0.81–0.89), 83% (95% CI, 0.77–0.87), 4.94 (95% CI, 3.61–6.75), and 0.18 (95% CI, 0.13–0.23) for these 20 studies. The corresponding AUC value was 0.91 (95% CI, 0.88–0.93), and the publication bias risk was low (P = 0.976). Cerebral blood flow–related diagnostic results were additionally reported in 6 of the analyzed studies, with respective pooled sensitivity, specificity, PLR, and NLR values of 85% (95% CI, 0.78–0.90), 85% (95% CI, 0.76–0.91), 5.54 (95% CI, 3.40–9.01), and 0.18 (95% CI, 0.12–0.26). The corresponding AUC value was 0.92 (95% CI, 0.89–0.94), and the publication bias risk was low (P = 0.373). Conclusions The present meta-analysis results suggest that dynamic susceptibility contrast-enhanced perfusion-weighted imaging represents an effective diagnostic approach to distinguishing between PsP and RT in high-grade glioma patients.

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Assessment of glioma response to radiotherapy using 3D pulsed-continuous arterial spin labeling and 3D segmented volume

Cited by 13 publications

References 26 publications

Arterial spin labeling for the measurement of cerebral perfusion and angiography

Arterial spin labeling for the measurement of cerebral perfusion and angiography

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted Imaging in Differentiation Between Recurrence and Pseudoprogression in High-Grade Glioma: A Meta-analysis

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