Assessment of genetic polymorphism associated with ATP-binding cassette transporter A1 (ABCA1) gene and fluctuations in serum lipid profile levels in patients with coronary artery disease

Bogari, Neda M.; Babalghith, Ahmad O.; Bouazzaoui, Abdellatif; Aljohani, Ashwag; Dannoun, Anas; Elkhateeb, Osama; Amin, Amr; Mazhar, Abdulbari A.; Porqueddu, Massimo; Khan, Imran Ali

doi:10.1016/j.jsps.2021.11.007

Cited by 4 publications

(1 citation statement)

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“…In line with our findings, low expression of the gene in adipose tissue has been reported to be associated with insulin resistance and obesity 15 . Several variations in the gene have also been observed to have to role in HDL level alteration constituting varied blood sugar levels, and it has also been highlighted in a study that managing dyslipidemia can prevent further progression of diabetes Mellitus [16][17][18] .ABCA1 has also been presented as a repressor of inflammation which is a contributor in the baseline pathology of DM 19 . ABCA1 genetic mapping has been proposed to manage lipid levels among type II DM patients 20 .…”

Section: Discussionmentioning

confidence: 99%

Expression analysis of ABCA1 in type 2 diabetic Pakistani patients with and without dyslipidemia and correlation with glycemic index and lipid profile

Zaidi,

Rashid,

Majeed

et al. 2023

Sci Rep

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Diabetes Mellitus type II, earlier considered as an endocrinological disorder is now more regarded as an inflammatory disorder along with lipid aberrations. It demands for regular monitoring, healthy dietary habits and lifestyle modification. This study was focused on gene expression of ATP binding cassette protein 1 (ABCA1) in diabetic dyslipidemia patients in comparison with control groups of only diabetics and healthy individuals. Blood samples and data were collected from recruited 390 patients who were further divided into three groups (130 each). Glycemic index and lipid profile was assessed. Delta Delta Ct method was used that revealed downregulation of the studied gene more in diabetic dyslipidemia patients as compared to only diabetics and healthy controls. The Ct values of ABCA1 were associated with glycemic index and lipid profile using Pearson’s correlation. A negative correlation with fasting blood sugar and a positive correlation with HbA1cwas observed in only diabetics group. While in diabetic dyslipidemia and normal healthy controls, a negative correlation was found with both. As far as the lipid profile is concerned a positive correlation was observed among only diabetics with whole lipid profile. In diabetics with dyslipidemia, a negative correlation with all parameters except the TAGs was observed. A positive correlation with all except HDL was observed in healthy controls. The Ct values and fold change were compared among diseased and healthy individuals by applying independent t test. The cycle threshold in only diabetics was p = 0.000018 and in diabetic dyslipdemia individuals was p = 0.00251 while fold change in only diabetics (p = 0.000230) and in diabetics with dyslipidemia (p = 0.001137) was observed to be as statistically significant.

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