Assessment of general movements and heart rate variability in prediction of neurodevelopmental outcome in preterm infants

Dimitrijević, Ljiljana; Bjelaković, Bojko; Čolović, Hristina; Mikov, Aleksandra; Živković, Vesna; Kocić, Miodrag; Lukic, Stevo

doi:10.1016/j.earlhumdev.2016.05.014

Cited by 36 publications

(47 citation statements)

References 29 publications

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“…HRV is believed to be an effective tool to study not only cardiovascular function but also general maturation of the central nervous system (5,6). Several retrospective studies have revealed that children with compromised neurodevelopmental outcomes displayed reduced HRV during their neonatal period (5,6,22,23). Compromised HRV in our FGR neonates may thus also be reflective of suboptimal brain development in utero (24).…”

Section: Discussionmentioning

confidence: 94%

“…It could also be postulated, however, that compromised HRV is a consequence of altered neurodevelopment due to FGR (21). HRV is believed to be an effective tool to study not only cardiovascular function but also general maturation of the central nervous system (5,6). Several retrospective studies have revealed that children with compromised neurodevelopmental outcomes displayed reduced HRV during their neonatal period (5,6,22,23).…”

Section: Discussionmentioning

confidence: 99%

“…Autonomic function can be assessed noninvasively by means of heart rate variability (HRV) and baroreflex sensitivity (BRS) analysis (4). Using these techniques, altered autonomic cardiovascular control in early life has been related to compromised neurodevelopmental outcome in childhood (5,6). Moreover, studies in adults have recognized relative sympathetic hyperactivity as the main pathophysiologic mechanism causing hypertension (7).…”

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confidence: 99%

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Fetal-growth-restricted preterm infants display compromised autonomic cardiovascular control on the first postnatal day but not during infancy

et al. 2017

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BackgroundFetal growth restriction (FGR) is associated with increased perinatal mortality and long-term cardiovascular and neurodevelopmental sequelae. We hypothesized that FGR impacts on the development of autonomic heart rate and blood pressure control, contributing to unfavorable short- and long-term outcomes following FGR.MethodsWe studied 25 preterm FGR and 22 preterm and 19 term appropriate for gestational age (AGA) infants. Preterm neonates were studied on postnatal day 1, and all infants were studied at 1 and 6 months post-term age. To investigate autonomic cardiovascular control, we examined heart rate variability (HRV) and baroreflex sensitivity using spectral power and transfer-function analyses.ResultsPreterm FGR neonates exhibited higher heart rates and reduced HRV compared with preterm AGA controls on postnatal day 1. No significant differences were found between the three groups at 1 or 6 months post-term age.ConclusionPreterm FGR neonates display compromised HRV on postnatal day 1, which may suggest increased vulnerability to circulatory instability. This may predispose these neonates to systemic and cerebral hypoperfusion and increase the risk of long-term neurodevelopmental sequelae. Differences were no longer found at 1 and 6 months post-term age, suggesting that the maturation of autonomic cardiovascular control may be preserved following FGR.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Fetal-growth-restricted preterm infants display compromised autonomic cardiovascular control on the first postnatal day but not during infancy

et al. 2017

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“…In preterms, the high frequency component of HRV was shown to be a good biomarker of necrotizing enterocolitis, an acute neonatal inflammatory disease which may lead to death [6]. HRV features together with quantification of general physical movements have also been found useful for 2-year outcome prediction in [7]. In [8], time-domain HRV measurements have showed a significant difference between septic and nonseptic newborns.…”

Section: Introductionmentioning

confidence: 99%

Heart Rate Variability during Periods of Low Blood Pressure as a Predictor of Short-Term Outcome in Preterms

Semenova

Carra

Lightbody

et al. 2018

2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Efficient management of low blood pressure (BP) in preterm neonates remains challenging with a considerable variability in clinical practice. The ability to assess preterm wellbeing during episodes of low BP will help to decide when and whether hypotension treatment should be initiated. This work aims to investigate the relationship between heart rate variability (HRV), BP and the short-term neurological outcome in preterm infants less than 32 weeks gestational age (GA). The predictive power of common HRV features with respect to the outcome is assessed and shown to improve when HRV is observed during episodes of low mean arterial pressure (MAP)with a single best feature leading to an AUC of 0.87. Combining multiple features with a boosted decision tree classifier achieves an AUC of 0.97. The work presents a promising step towards the use of multimodal data in building an objective decision support tool for clinical prediction of short-term outcome in preterms who suffer episodes of low BP.

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“…Показатели вариабельности сердечного ритма имеют потенциально важное значение для оценки вегетативной дисфункции и персонального прогноза у детей [10][11][12]. Изменения вариабельности сердечного ритма могут быть использованы у недоношенных новорожденных для прогнозирования развития неврологических нарушений [13,14], а также риска ранних вегетативно обусловленных осложнений [15].…”

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Peculiarities of Heart Rate Variability in Newborns

Панина¹,

Kiselev²,

Боровкова³

et al. 2018

Ross. vestn. perinatol. pediatr.

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Heart rate variability values are potentially important for assessing vegetative dysfunction in children.The purpose of the research: a comparative study of spectral heart rate variability parameters and synchronization of low-frequency oscillations, characterizing baroreflex in the vegetative regulation of the cardiovascular system in healthy newborns and adults.15 healthy newborns and 60 healthy individuals in the age of 18-34 years old were included in the study. We performed synchronous recording of electrocardiograms and photoplethysmograms with 10 minutes duration, at rest. Were evaluated spectral heart rate variability indices and the index of synchronization of low-frequency oscillations in heart rate variability and photoplethysmograms (S index).Results. In newborns, the peak of low-frequency oscillations was predominantly in the range 0.07–0.09 Hz, and high frequency 0.40–0.50 Hz. Newborns had lower LF% values than adults: 22.8 (14.1, 29.4) vs 32.9 (25.1, 41.9) (p=0.009). The S index in newborns was 20.1 (16.9, 26.5)%, and 33.2 (21.2, 45.4)% in healthy adults (p=0.023).Conclusion. We have first demonstrated that the interaction of baroreflex regulation of heart rhythm and peripheral blood filling in healthy newborns is characterized by lower values of S index, than in healthy adults, which can be explained by the immaturity of the vegetative regulatory elements of the cardiovascular system.

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Assessment of general movements and heart rate variability in prediction of neurodevelopmental outcome in preterm infants

Cited by 36 publications

References 29 publications

Fetal-growth-restricted preterm infants display compromised autonomic cardiovascular control on the first postnatal day but not during infancy

Fetal-growth-restricted preterm infants display compromised autonomic cardiovascular control on the first postnatal day but not during infancy

Heart Rate Variability during Periods of Low Blood Pressure as a Predictor of Short-Term Outcome in Preterms

Peculiarities of Heart Rate Variability in Newborns

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