Assessment of Gastroesophageal Reflux Symptoms and Sleep Quality Among Women in the Nurses’ Health Study II

Abstract

ImportanceLimited data exist on the association of gastroesophageal reflux (GER) symptoms with sleep quality.ObjectiveTo prospectively investigate the association between GER symptoms and sleep quality.Design, Setting, and ParticipantsThis prospective cohort study included data from the Nurses’ Health Study II of female nurses in the US. Participants self-reported the frequency and duration of GER symptoms beginning June 2005, with updates every 4 years through June 2015. Follow-up was completed June 2019, and data were analyzed from November 15, 2022, to June 4, 2023.ExposuresFrequency and duration of GER symptoms.Main Outcomes and MeasuresPoor sleep quality was assessed in 2017 through a modified Pittsburgh Sleep Quality Index, which included difficulty in falling asleep, restlessness of sleep, daytime sleepiness, sleep disturbance, and sleep duration. Relative risk (RR) for poor sleep quality and individual components of poor sleep quality was estimated according to the frequency and duration of GER symptoms.ResultsAmong 48 536 women (median age, 59 years [range, 48-69 years]), 7929 (16.3%) developed poor sleep quality during 4 years of follow-up. Compared with those with GER symptoms less than once a month, the multivariable RR for poor sleep quality among women with GER symptoms more than once a week was 1.53 (95% CI, 1.45-1.62). Women who had GER symptoms once or more a week for more than 7 years had an RR of 1.36 (95% CI, 1.30-1.43) compared with women who had not had GER symptoms once or more a week. The frequency and duration of GER symptoms were significantly associated with each individual component of poor sleep quality; for example, the multivariable RRs for GER symptoms 2 or more times per week compared with no GER symptoms were 1.49 (95% CI, 1.39-1.58) for difficulty in falling asleep, 1.47 (95% CI, 1.39-1.56) for excessive daytime sleepiness, and 1.44 (95% CI, 1.36-1.53) for restlessness of sleep.Conclusions and RelevanceIn this prospective cohort study of female nurses in the Nurses’ Health Study II, the frequency and duration of GER symptoms were associated with subsequent risk of poor sleep quality. The findings suggest that effective treatment of GER disease may be important not only for improvement of symptoms but also for the reduction of comorbidities associated with poor sleep quality.

Scoping review: the social and emotional impacts of gastroparesis

“…It is worth noting there is likely a reciprocal relationship between sleep quality and GI symptoms including nausea and abdominal pain. Patients with GI conditions tend to report poorer sleep quality than healthy controls ( 37 - 39 ). In patients with IBS, more waking episodes during sleep was predictive of more abdominal pain ( 38 ), GI distress, and worse quality of life but not bowel consistency or frequency ( 37 ).…”

Gastroezofaginio Refliukso Rizikos Veiksnių Pasiskirstymas Tarp Skirtingo Amžiaus Grupių

“…Stresas. Sutrikęs miegas didina lėtinių ligų riziką [21]. Stresas taip pat neigiamai veikia GERL simptomų išsivystymą.…”

“…Stresas taip pat neigiamai veikia GERL simptomų išsivystymą. Kartu su prasta miego kokybe ir kūno nuovargiu, tai ženkliai padidina GERL pasireiškimo tikimybę ar dažnesnį GERL simptomų paūmėjimą [3,21]. Išvados 1.…”

Prevalence and bidirectional association of sleep quality and gut health among Chinese midwives: a large population, multi-center cross-sectional study

“…While some studies have indicated that shift work may impact the gastrointestinal diseases of nurses (8,9), it remains debated whether this effect is related to sleep quality, as some studies suggest that this association may be independent of sleep quality (11). Concurrently, several studies have highlighted the significant impact of sleep quality on adverse gut conditions (13)(14)(15). Understanding the impact of sleep quality on adverse gut conditions is crucial, especially given the emerging interest in the gut-brain axis theory.…”