Assessment of gallbladder function using ceruletide in oral cholecystography

Morewood, D.J.W.; Whitehouse, G. H.

doi:10.1007/bf01893080

Cited by 2 publications

(2 citation statements)

References 19 publications

(29 reference statements)

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“…Therefore, a single measurement taken between 30 and 40 min allows accurate quantification of maximum gallbladder emptying. Quite comparable results were obtained by other investigators who used IM ceruletide (0.3 #g/kg) during OCG in place of a fatty meal [18][19][20], thus indicating that the time-response curve after ceruletide is very reproducible. Although we studied a more limited number of subjects, individual variation of gallbladder emptying was lower than that reported by Donald et al in normal adults [3], since two thirds of our patients exhibited variations lower than 20%.…”

Section: Discussionsupporting

confidence: 82%

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Ultrasonic evaluation of gallbladder emptying with ceruletide: comparison to oral cholecystography with fatty meal

et al. 1994

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Assessment of gallbladder function is required prior to nonsurgical treatment of gallstones. In order to develop a practical and reproducible method of evaluation, gallbladder emptying was studied by ultrasound (US) in 55 gallstone patients after intramuscular administration of ceruletide (0.3 micrograms/kg). In 27 of these subjects, the US procedure was compared to oral cholecystography (OCG) with fatty meal. Maximal percent gallbladder contraction was reached 30 min after ceruletide in all patients. Maximal percent contractions were 47.5 +/- 27.7 during US with ceruletide and 33.9 +/- 16.3 during OCG with fatty meal (p = 0.03). A significant linear relationship was found between the results obtained with the two different procedures (r = 0.57; p = 0.002). Serial US determinations of gallbladder emptying were performed in 16 patients. Individual variation was below 20% in 11 subjects, and in five subjects it ranged between 20 and 40%. Minor, self-limiting side effects were observed in 13 patients. US determination of gallbladder emptying after ceruletide appears to be a practical and reliable method to assess gallbladder function.

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Section: Discussionsupporting

confidence: 82%

“…Moderate, diffuse abdominal pain and nausea are probably secondary to stimulation of intestinal motility by the peptide [14]. Biliary colic after administration of ceruletide in gallstone patients was never observed either in the present or in previous studies [18][19][20].…”

Section: Discussioncontrasting

confidence: 71%

Ultrasonic evaluation of gallbladder emptying with ceruletide: comparison to oral cholecystography with fatty meal

et al. 1994

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Bile duct measurements after ceruletide as an aid to the ultrasound diagnosis of choledocholithiasis

Mendelson

Tobin

Gilmore

1988

Gastrointest Radiol

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Despite good results in gallbladder imaging, ultrasound (US) diagnosis of choledocholithiasis remains a challenge. The value of US before and after a provocative injection of the decapeptide ceruletide was examined in 25 patients with suspected common duct stones immediately prior to diagnostic retrograde cholangiography. An abnormal response (increase in US duct diameter) was seen in 4 of 6 patients with an obstructed duct, giving a sensitivity of 67% and predictive value of 80% for the procedure. There was a normal response (decrease in US diameter of a dilated duct or decrease/no change in a normal duct) in 14 of 19 with an unobstructed duct (specificity 79%, predictive value 93%) and an equivocal response (no change in diameter of a dilated duct) in 5 patients. In 1 patient a calculus not seen on the initial US became visible as the duct distended by ceruletide administration. Symptoms after ceruletide were few and not discriminatory. Although it added to the time and difficulty of performing biliary US, ceruletide administration proved a useful adjunct to the diagnosis of choledocholithiasis.

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Assessment of gallbladder function using ceruletide in oral cholecystography

Cited by 2 publications

References 19 publications

Ultrasonic evaluation of gallbladder emptying with ceruletide: comparison to oral cholecystography with fatty meal

Ultrasonic evaluation of gallbladder emptying with ceruletide: comparison to oral cholecystography with fatty meal

Bile duct measurements after ceruletide as an aid to the ultrasound diagnosis of choledocholithiasis

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