Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI

Wang, Ze; Fernández‐Seara, María A.; Alsop, David C.; Liu, Wen‐Ching; Flax, Judy; Benasich, April A.; Detre, John A.

doi:10.1016/j.neuroimage.2007.09.045

Cited by 61 publications

(51 citation statements)

References 45 publications

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“…After consumption of a flavanolrich cocoa drink, the 'flow oxygenation level dependent' (BOLD)-fMRI showed an increase in blood flow in certain regions of the brain, along with a modification of the BOLD response to task switching. Furthermore, 'arterial spin-labelling sequence magnetic resonance imaging' (ASL-MRI) [127] also indicated that cocoa flavanols increase CBF up to a maximum of two hours after ingestion of the flavanol-rich drink. In support of these findings, an increase in cerebral blood flow through the middle cerebral artery has been reported after the consumption of flavanol-rich cocoa using TCD [29].…”

Section: Cerebrovascular Effects Of Flavonoidsmentioning

confidence: 99%

The neuroprotective potential of flavonoids: a multiplicity of effects

et al. 2008

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Flavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning and cognitive function. These effects appear to be underpinned by two common processes. Firstly, they interact with critical protein and lipid kinase signalling cascades in the brain leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Secondly, they induce beneficial effects on the vascular system leading to changes in cerebrovascular blood flow capable of causing angiogenesis, neurogenesis and changes in neuronal morphology. Through these mechanisms, the consumption of flavonoid-rich foods throughout life holds the potential to limit neurodegeneration and to prevent or reverse age-dependent loses in cognitive performance. The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs.

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Section: Cerebrovascular Effects Of Flavonoidsmentioning

confidence: 99%

The neuroprotective potential of flavonoids: a multiplicity of effects

et al. 2008

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“…Discussion ASL perfusion MR imaging was first described more than 10 years ago 20 and has been an active area of research. [21][22][23][24][25][26][27] ASL has several advantages compared with conventional bolustracking methods for migraine imaging. ASL requires no gadolinium-based contrast, can be repeated in the same session, and provides information on absolute CBF.…”

Section: Patientmentioning

confidence: 99%

Migraine Associated Cerebral Hyperperfusion with Arterial Spin-Labeled MR Imaging

Pollock¹,

Deibler²,

Burdette³

et al. 2008

AJNR Am J Neuroradiol

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SUMMARY:We present a case series demonstrating abnormal regional cerebral hyperperfusion associated with migraine headache using arterial spin-labeling (ASL). In 3 of 11 patients, regional cortical hyperperfusion was demonstrated during a headache episode that corresponded to previous aura symptoms. Migraine is a common condition affecting 12% of the United States population per year.1 Migraines classically present with unilateral debilitating, painful headaches associated with photophobia, phonophobia, nausea, and vomiting. Less than 30% of migraines are preceded by auras, or focal neurologic deficits. Most commonly, the neurologic deficits are visual, but sensory and motor deficits can also occur. The pathophysiology of a migraine is complex and is not completely understood. The vascular theory proposes that the migraine aura is associated with vasoconstriction and the subsequent headache is associated with vasodilation and hyperperfusion.3,4 The second theory is that a contiguous wave of neuronal depression spreads through the cortex causing the aura symptoms.5-10 The vascular changes have been evaluated with nuclear medicine studies including single-photon emission CT and positron-emission tomography as well as blood oxygen level-dependent functional MR imaging and T2* dynamic susceptibility contrast (DSC) MR perfusion imaging. 3,8,9,[11][12][13] These methods are limited in the evaluation of the patient with migraine because of the dynamic nature of the perfusion abnormalities.Spin tag perfusion imaging is an MR imaging method that measures quantitative cerebral blood flow (CBF).14 The advantages of arterial spin-labeling (ASL) compared with conventional perfusion techniques include repeatability, absolute quantification, and the avoidance of intravenous contrast administration. 15,16 We performed a retrospective analysis of MR imaging examinations including ASL perfusion in patients with an indication of headache from the past 12 months and identified 11 clinical patients with a history of migraine headache. We present the 3 patients with migraine-associated regional cerebral hyperperfusion corresponding to the clinical presentation. Case Reports Patient 1A 55-year-old woman with a history of hemiplegic migraines presented with new-onset right frontal headache, left-sided numbness, weakness, and dysarthria. The patient took prochlorperazine (Compazine) at home without relief of her symptoms. We performed cerebral MR imaging 6 hours after onset of symptoms using our standard stroke protocol including conventional sequences and ASL perfusion. Conventional MR imaging sequences demonstrated subtle sulcal effacement and mild edema in the right frontal cortex without evidence of diffusion abnormality (Fig 1).We generated quantitative CBF maps using quantitative imaging of perfusion and a single subtraction with thin-section inversion time (TI) 1 periodic saturation with a flow-sensitive alternating inversion recovery sequence as described previously.17 This sequence generates 60 tag and control image pairs. Imag...

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“…Many other studies have looked at functional network development in young infants [19,20,22,56]. Fransson et al, in particular, examined the resting-state functional network architecture of very young preterm infants (25 weeks mean gestational age) and found that only half of the number of resting-state sub-networks found in healthy adults were present at the preterm stage [20].…”

Section: Introductionmentioning

confidence: 99%

Structural network analysis of brain development in young preterm neonates

et al. 2014

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Preterm infants develop differently than those born at term and are at higher risk of brain pathology. Thus, an understanding of their development is of particular importance. Diffusion tensor imaging (DTI) of preterm infants offers a window into brain development at a very early age, an age at which that development is not yet fully understood. Recent works have used DTI to analyze structural connectome of the brain scans using network analysis. These studies have shown that, even from infancy, the brain exhibits small-world properties. Here we examine a cohort of 47 normal preterm neonates (i.e., without brain injury and with normal neurodevelopment at 18 months of age) scanned between 27 and 45 weeks post-menstrual age to further the understanding of how the structural connectome develops. We use fullbrain tractography to find white matter tracts between the 90 cortical and sub-cortical regions defined in the University of North Carolina Chapel Hill neonatal atlas. We then analyze the resulting connectomes and explore the differences between weighting edges by tract count versus fractional anisotropy. We observe that the brain networks in preterm infants, much like infants born at term, show high efficiency and clustering measures across a range of network scales. Further, the development of many individual region-pair connections, particularly in the frontal and occipital lobes, is significantly correlated with age. Finally, we observe that the preterm infant connectome remains highly efficient yet becomes more clustered across this age range, leading to a significant increase in its small-world structure.

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Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI

Cited by 61 publications

References 45 publications

The neuroprotective potential of flavonoids: a multiplicity of effects

The neuroprotective potential of flavonoids: a multiplicity of effects

Migraine Associated Cerebral Hyperperfusion with Arterial Spin-Labeled MR Imaging

Structural network analysis of brain development in young preterm neonates

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