Assessment of food toxicology

Gosslau, Alexander

doi:10.1016/j.fshw.2016.05.003

Cited by 17 publications

(9 citation statements)

References 194 publications

(322 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Methodologies for the assessment of food peptide toxicity are beyond the scope of this review. For a review on the in vitro, in vivo and in silico tools used for evaluating toxicology of food, the reader is referred to Gosslau [ 115 ]. For a comprehensive discussion on empirical and in silico approaches to designing peptides with low toxicity and to predicting peptide toxicity, we refer the reader to Gupta et al [ 114 ].…”

Section: Current Gaps In Knowledge and Future Perspectivesmentioning

confidence: 99%

Enzyme-Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

et al. 2017

View full text Add to dashboard Cite

Marine invertebrates, such as oysters, mussels, clams, scallop, jellyfishes, squids, prawns, sea cucumbers and sea squirts, are consumed as foods. These edible marine invertebrates are sources of potent bioactive peptides. The last two decades have seen a surge of interest in the discovery of antioxidant peptides from edible marine invertebrates. Enzymatic hydrolysis is an efficient strategy commonly used for releasing antioxidant peptides from food proteins. A growing number of antioxidant peptide sequences have been identified from the enzymatic hydrolysates of edible marine invertebrates. Antioxidant peptides have potential applications in food, pharmaceuticals and cosmetics. In this review, we first give a brief overview of the current state of progress of antioxidant peptide research, with special attention to marine antioxidant peptides. We then focus on 22 investigations which identified 32 antioxidant peptides from enzymatic hydrolysates of edible marine invertebrates. Strategies adopted by various research groups in the purification and identification of the antioxidant peptides will be summarized. Structural characteristic of the peptide sequences in relation to their antioxidant activities will be reviewed. Potential applications of the peptide sequences and future research prospects will also be discussed.

show abstract

Section: Current Gaps In Knowledge and Future Perspectivesmentioning

confidence: 99%

Enzyme-Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The biocompatibility of materials is routinely evaluated using in vitro methodologies. Cell lines are often cultivated in contact with test materials, and after a variable period, the cellular metabolic activity, proliferation and/or death rates are measured (Gosslau 2016). In this study, a resazurin solution was used to assess the cellular viability of Caco-2 after incubation with BCNF-based films or with the respective controls.…”

Section: Cytotoxicity-cell Viability Through Resazurin Assaymentioning

confidence: 99%

Bacterial cellulose nanofiber-based films incorporating gelatin hydrolysate from tilapia skin: production, characterization and cytotoxicity assessment

et al. 2018

View full text Add to dashboard Cite

In this work, films based on bacterial cellulose nanofibers (BCNFs) incorporating gelatin hydrolysate (GH) from tilapia skin were produced. The effect of plasticizer (sorbitol or glycerol) and GH incorporation was evaluated on the physical-chemical and optical properties of films. BCNFs were produced using bacterial cellulose obtained from Hestrin and Schramm (HS) medium (BCNF-HS) or cashew apple juice (BCNF-CM), which was studied as an alternative to HS. Films with sorbitol showed the best properties and were selected for further characterization, using 40% (w/w) of BCNF-HS, 40% (w/w) of GH and 20% (w/w) of sorbitol (BCNF-HS-S-GH films). These films exhibited an antioxidant activity of 7.8 lmols Trolox Eq/g film, a water vapor permeability (WVP) of 1.6 g.mm/kPa.h.m 2 and an Young's modulus of 0.57 GPa. Films produced with BCNFs obtained from cashew apple juice revealed enhanced tensile strength, elongation at break, and thermal stability. Caco-2 cells' viability after incubation with BCNF-based films incorporating GH was evaluated and showed non-cytotoxicity, reinforcing the safety of the developed materials and their potential use in food applications.

show abstract

“…Currently, these non-testing in silico methods can only provide limited insights (Raies and Bajic 2018;Benfenati et al 2019). However, the integration of food toxicology data obtained via cell-based in vitro and in vivo animal models as well as in silico systems have led to a mechanistic knowledge of systemic or organ-specific toxicity in humans and the identification and use of specific surrogate biomarkers in clinical settings (Gosslau 2016).…”

Section: Resultsmentioning

confidence: 99%

Alternative model organisms for toxicological fingerprinting of relevant parameters in food and nutrition

Sandner

König

Wallner

et al. 2021

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

In the field of (food) toxicology, there is a strong trend of replacing animal trials with alternative methods for the assessment of adverse health effects in humans. The replacement of animal trials is not only driven by ethical concerns but also by the number of potential testing substances (food additives, packaging material, contaminants, and toxicants), which is steadily increasing. In vitro 2D cell culture applications in combination with in silico modeling might provide an applicable first response. However, those systems lack accurate predictions of metabolic actions. Thus, alternative in vivo models could fill the gap between cell culture and animal trials. In this review, we highlight relevant studies in the field and spotlight the applicability of alternative models, including C. elegans, D. rerio, Drosophila, HET-CAM and Lab-on-a-chip.

show abstract

Assessment of food toxicology

Cited by 17 publications

References 194 publications

Enzyme-Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

Enzyme-Assisted Discovery of Antioxidant Peptides from Edible Marine Invertebrates: A Review

Bacterial cellulose nanofiber-based films incorporating gelatin hydrolysate from tilapia skin: production, characterization and cytotoxicity assessment

Alternative model organisms for toxicological fingerprinting of relevant parameters in food and nutrition

Contact Info

Product

Resources

About