Assessment of Fibrosis by Transient Elastography Compared With Liver Biopsy and Morphometry in Chronic Liver Diseases

Quantification of portal–bridging fibrosis area more accurately reflects fibrosis stage and liver stiffness than whole fibrosis or perisinusoidal fibrosis areas in chronic hepatitis C

“…A few morphometric studies have focused on the different fibrosis compartments in CHC, [24][25][26][27][28] but owing to variations in methods, patient populations, and study goals, the results are hardly comparable to ours and between each other. The largest series in nontreated patients with chronic viral hepatitis showed that perisinusoidal fibrosis was twice more prominent in chronic hepatitis C than in chronic hepatitis B in early fibrosis stages (Fr2).…”

“…4 Some studies also used image analysis of liver tissue to evaluate correlations between the proportion of whole collagen fibrosis and transient elastography. 27,[38][39][40] Wong et al 27 observed in an univariate analysis that 'pericellular fibrosis' better correlated with liver stiffness measurement than 'periportal' or 'perivenular fibrosis,' especially in patients with severe fibrosis. This study and ours are barely comparable, because of size difference and different methodology.…”

MR Elastography for the Assessment of Hepatic Fibrosis in Patients with Chronic Hepatitis B Infection: Does Histologic Necroinflammation Influence the Measurement of Hepatic Stiffness?

“…Studies involving the use of transient elastography have shown that it is not accurate for physicians to apply the same stiffness cutoff values determined in patients with chronic HCV infection to the population with chronic HBV infection for evaluation of hepatic fibrosis (7,30). Likewise, the cutoff stiffness values for MR elastography that optimize the sensitivity and specificity in chronic HCV infection might cause over-or underestimation of the real fibrotic status in chronic HBV infection (10,15,16,31,32). Hence, the aim of this study was to determine the diagnostic performance of MR elastography for the staging of hepatic fibrosis and evaluate the influence of necroinflammation on hepatic stiffness in patients with chronic HBV infection by using histopathologic findings as the reference standard.…”

Comparison between Transient Elastography (FibroScan) and Liver Biopsy for the Diagnosis of Hepatic Fibrosis in Chronic Hepatitis C Patients

“…Perazzo et al [30] attributed this over-estimation of liver fibrosis by TE to flare of transaminases, extrahepatic cholestasis and liver congestion, non-fasting status, and liver steatosis. Wong et al [31] concluded that TE might overestimate liver fibrosis when ALT is elevated in cases of chronic hepatitis B or C.…”