Assessment of fetal cardiac morphology and functional changes in early‐onset and late‐onset fetal growth restriction

Oluklu, Deniz; Beşer, Dilek Menekşe; Hendem, Derya Uyan; Yıldırım, Muradiye; Koç, Bergen Laleli; Şahın, Dilek

doi:10.1002/ijgo.14602

Cited by 7 publications

(16 citation statements)

References 37 publications

(74 reference statements)

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“…IVCT is the most stable parameter of MPI 10 . Reduced E/A ratios and increased MPI values in IUGR fetuses have been demonstrated in the literature [17][18][19] . Interestingly, some studies found higher left ventricular MPI values and higher E/A ratios in fetuses with PPROM with microbial invasion of the amniotic cavity and with signs of fetal inflammatory response syndrome 20,21 .…”

Section: Discussionmentioning

confidence: 85%

Assessment Of Fetal Cardiac Functions In Pregnant Women Wı̇th Asthma

Koç

Oluklu

Hendem

et al. 2023

Preprint

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Aim:This study aims to investigate the effects of maternal asthma on fetal cardiac functions. Methods:The study was planned with 30 pregnant women who presented to a tertiary health center and were diagnosed with asthma and 60 healthy controls with similar gestational ages. The fetal echocardiographic assessment was assessed between 33 and 35 weeks of gestation with pulsed-wave Doppler (PW), M-mode, and tissue Doppler imaging (TDI). Fetal cardiac functions were compared between maternal asthma and control group. Cardiac functions were assessed according to the duration of maternal asthma diagnosis, as well. Results:Early diastolic function parameters, tricuspid E wave (p=0.001), and tricuspid E/A ratio (P=0.005) were significantly lower in the group with maternal asthma. TAPSE and MAPSE values were statistically lower in the study group than in the control group; p=0.010 and p=0.012, respectively. Parameters assessed with TDI (E’, A’, S’, E/E’, and MPI’ of tricuspid valves) and global cardiac function parameters assessed with pulsed-wave Doppler like myocardial performance index (MPI) and left cardiac output (LCO) were similar between groups (p> 0.05). Although, MPI did not change between groups, and the isovolumetric relaxation time (IVRT) value was prolonged in maternal asthma cases (p=0.025). Conclusion:We found that maternal asthma disease causes alteration in fetal diastolic and early systolic cardiac functions, but the global fetal cardiac function does not change. Diastolic heart function values also varied with the duration of maternal asthma. Prospective studies are needed to compare fetal cardiac functions with additional patient groups according to disease severity and type of medical treatment.

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Section: Discussionmentioning

confidence: 85%

Assessment Of Fetal Cardiac Functions In Pregnant Women Wı̇th Asthma

Koç

Oluklu

Hendem

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…IVCT is the most stable parameter of MPI 10 . Reduced E/A ratios and increased MPI values in IUGR fetuses have been demonstrated in the literature 17–19 . Interestingly, some studies found higher left ventricular MPI values and higher E/A ratios in fetuses with PPROM with microbial invasion of the amniotic cavity and with signs of fetal inflammatory response syndrome 20,21 .…”

Section: Discussionmentioning

confidence: 97%

“…10 Reduced E/A ratios and increased MPI values in IUGR fetuses have been demonstrated in the literature. [17][18][19] Interestingly, some studies found higher left ventricular MPI values and higher E/A ratios in fetuses with PPROM with microbial invasion of the amniotic cavity and with signs of fetal inflammatory response syndrome. 20,21 In another study investigating fetal heart functions in maternal familial Mediterranean fever (FMF) associated with chronic inflammation, it was found that fetal diastolic functions might be altered in fetuses of mothers with FMF.…”

Section: Discussionmentioning

confidence: 99%

Assessment of fetal cardiac functions in pregnant women with asthma

et al. 2023

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Aim This study aims to investigate the effects of maternal asthma on fetal cardiac functions. Methods The study was planned with 30 pregnant women who presented to a tertiary health center and were diagnosed with asthma and 60 healthy controls with similar gestational ages. The fetal echocardiographic assessment was assessed between 33 and 35 weeks of gestation with pulsed‐wave Doppler (PW), M‐mode, and tissue Doppler imaging (TDI). Fetal cardiac functions were compared between maternal asthma and the control group. Cardiac functions were assessed according to the duration of maternal asthma diagnosis, as well. Results Early diastolic function parameters, tricuspid E wave (p = .001), and tricuspid E/A ratio (p = .005) were significantly lower in the group with maternal asthma. Tricuspid annular plane systolic excursion (TAPSE) and measurements of mitral annular plane systolic excursion (MAPSE) values were statistically lower in the study group than in the control group; p = .010 and p = .012, respectively. Parameters assessed with TDI (E′, A′, S′, E/E′, and MPI′ of tricuspid valves) and global cardiac function parameters assessed with PW like myocardial performance index (MPI) and left cardiac output (LCO) were similar between groups (p > .05). Although, MPI did not change between groups, and the isovolumetric relaxation time (IVRT) value was prolonged in maternal asthma cases (p = .025). Conclusion We found that maternal asthma disease causes alteration in fetal diastolic and early systolic cardiac functions, but the global fetal cardiac function does not change. Diastolic heart function values also varied with the duration of maternal asthma. Prospective studies are needed to compare fetal cardiac functions with additional patient groups according to disease severity and type of medical treatment.

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“…This ratio can be used to evaluate ventricle compliance and relaxation by indicating whether ventricle filling is early-diastolic by negative pressure or late-diastolic by atrial contractile force. 12,13 Myocardial performance index (MPI or Tei index) was calculated using pulsed wave Doppler ultrasonography. To calculate MPI, position the caliper on the medial wall of the ascending aorta using a 5-chamber view of the heart that displays both the mitral and aortic valves in the same view (Figure 4).…”

Section: Ultrasound Assessmentmentioning

confidence: 99%

Do Maternal Heart Diseases Affect Fetal Cardiac Functions?

Okutucu,

Oluklu,

Gulen Yildiz

et al. 2024

J of Ultrasound Medicine

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ObjectivesTo investigate whether fetal cardiac function is affected by underlying heart disease in pregnant women.MethodsA total of 100 pregnant women who were ≥34 gestational weeks were included in the study, 40 in the maternal heart disease (MHD) group diagnosed with heart disease and 60 in the control group. All cardiac diseases in pregnant women were diagnosed preconceptionally and categorized according to the New York Heart Association (NYHA) classification system. Fetal cardiac functions of study groups were evaluated by M‐mode, color tissue Doppler imaging (c‐TDI), and pulsed wave Doppler.ResultsTricuspid annular plane systolic excursion and myocardial performance index (MPI) values were significantly higher and isovolumetric relaxation time was prolonged in the MHD group. The MPI value was found higher in MHD group with NYHA Class II compared to those with NYHA Class I. No significant change in any of the fetal tricuspid annular peak velocity values measured by c‐TDI in the MHD group. There were no differences in fetal cardiac functions and perinatal outcomes between pregnant women with acquired and congenital heart diseases. Patients in NYHA Class II had lower birth weight, 1st and 5th minute APGAR scores, and higher neonatal intensive care unit admission rates.ConclusionsUnderlying heart diseases in pregnant women can cause alterations in the systolic and diastolic function of the fetal heart. High fetal MPI values detected in cardiac patients may indicate that cardiac pathologies during pregnancy affect fetal cardiac globular myocardial function. Cardiac pathologies that progress with restricted physical activity may cause changes in fetal cardiac function and may be associated with adverse perinatal outcomes.

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Assessment of fetal cardiac morphology and functional changes in early‐onset and late‐onset fetal growth restriction

Cited by 7 publications

References 37 publications

Assessment Of Fetal Cardiac Functions In Pregnant Women Wı̇th Asthma

Assessment Of Fetal Cardiac Functions In Pregnant Women Wı̇th Asthma

Assessment of fetal cardiac functions in pregnant women with asthma

Do Maternal Heart Diseases Affect Fetal Cardiac Functions?

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