2024
DOI: 10.3389/fphar.2024.1466896
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Assessment of ferroptosis as a promising candidate for metastatic uveal melanoma treatment and prognostication

Ellie Swords,
Breandán N. Kennedy,
Valentina Tonelotto

Abstract: Uveal melanoma (UM) is the most common primary intraocular tumour in adults. Local resection, radiation therapy, and enucleation are the current first-line, primary UM treatments. However, regardless of the treatment received, around 50% of UM patients will develop metastatic disease within five to 7 years. In the largest published series of unselected patients with metastatic UM (mUM), the median survival time after diagnosis of metastasis was 3.6 months, with less than 1% of patients surviving beyond 5 years… Show more

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