Assessment of femoral neck strength and bone mineral density changes following exercise using 3D-DXA images

O’Rourke, Dermot; Beck, Belinda R.; Harding, Amy T; Watson, Steven L; Pivonka, Peter; Martelli, Saulo

doi:10.1016/j.jbiomech.2021.110315

Cited by 13 publications

(15 citation statements)

References 34 publications

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“…The PubMed search was performed on April 16, 2021, and produced 299 results, of which 33 fulfilled the inclusion criteria. Twelve additional papers [11][12][13][14][15][16][17][18][19][20][21][22] were included, as they fulfilled all inclusion criteria albeit without appearing in the PubMed search. All included papers are listed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…SSAM-based FE models can be used to evaluate the effect or preventive treatment. For example, O’Rourke et al [ 11 ] used the 2D-to-3D reconstruction method by Humbert et al [ 23 ] and built FE models from the reconstructed 3D DXA to predict femoral strength in a cohort of men where DXA images were acquired pre- and post-exercise interventions. Additionally, femoral strength was predicted for a cohort of women with same-day repeated DXA scans (where 0% strength change should be expected).…”

Section: Resultsmentioning

confidence: 99%

“…One of the applications of SSAMs that is increasingly popular is FE analysis. SSAM-based FE models could be aimed at, e.g., predicting subject-specific bone strength from clinical images [21,28,30,31], evaluating the efficacy of treatment [11], investigating the effect of femoral anatomy on its strength [29], estimating range of motions [26], and providing augmented information to clinical images [16,17].…”

Section: Finite Element Analysismentioning

confidence: 99%

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Statistical Shape and Appearance Models: Development Towards Improved Osteoporosis Care

Grassi

Väänänen

Isaksson

2021

Curr Osteoporos Rep

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Purpose of Review Statistical models of shape and appearance have increased their popularity since the 1990s and are today highly prevalent in the field of medical image analysis. In this article, we review the recent literature about how statistical models have been applied in the context of osteoporosis and fracture risk estimation. Recent Findings Recent developments have increased their ability to accurately segment bones, as well as to perform 3D reconstruction and classify bone anatomies, all features of high interest in the field of osteoporosis and fragility fractures diagnosis, prevention, and treatment. An increasing number of studies used statistical models to estimate fracture risk in retrospective case-control cohorts, which is a promising step towards future clinical application. Summary All the reviewed application areas made considerable steps forward in the past 5–6 years. Heterogeneities in validation hinder a thorough comparison between the different methods and represent one of the future challenges to be addressed to reach clinical implementation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Finite Element Analysismentioning

confidence: 99%

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Statistical Shape and Appearance Models: Development Towards Improved Osteoporosis Care

Grassi

Väänänen

Isaksson

2021

Curr Osteoporos Rep

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“…Studies were included that showed quantification of BMD. The inclusion criteria adopted were: (i) complete studies performed in humans over 55 years old (to ensure selection of studies including only participants with a recognized trend of age-related effects on BMD) [ 23 , 24 ]; (ii) only studies that used dual-energy X-ray absorptiometry (DXA) as the assessment tool, a validated BMD measurement technique [ 25 ]; (iii) peer-reviewed and published in English; and (iv) in the last 10 years. The exclusion criteria adopted were: (i) studies conducted in clinical populations that interfere with bone metabolism (i.e., diabetics, obese) [ 3 ]; (ii) with average body mass index ≥ 30.0 kg/m 2 ; (iii) studies that combined other types of exercises (i.e., vibration, impact, and aerobic exercises); (iv) studies that administered supplements or osteogenic drugs; (v) case studies and literature reviews (systematic review and meta-analysis).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Resistance Training on Bone Mineral Density in Older Adults: A Systematic Review and Meta-Analysis

et al. 2022

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Resistance training (RT) has been considered an intervention with effective stimulus on bone mineral formation and is, therefore, recommended to decrease the rate of bone morpho-functional proprieties loss with aging. Thus, this meta-analysis aimed to analyze the effectiveness of RT protocols in promoting changes in bone mineral density (BMD) in older adults. The systematic reviews and meta-analysis followed the PRISMA guidelines (PROSPERO CRD42020170859). The searches were performed in the electronic databases using descriptors according to the PICO strategy. The methodological quality and risk of bias were assessed with the PEDro scale, and the magnitude of the results was determined by Hedges’ g. Seven studies involving 370 elderlies, with the RT planned as a unique exercise mode of intervention, showed designs with four to five exercises for upper- and lower-limbs musculature, two to three sets per exercise, eight to twelve repetitions to failure at 70–90% 1 RM, 60–120 s of rest between sets, and executed three times per week for 12–52 weeks. The RT protocols were classified between good and excellent and evidenced a positive effect on the BMD at the hip (0.64%) and spine (0.62%) but not in the femoral neck (−0.22%) regardless of the intervention length. The narrow range of either positive or negative changes in the BMD after the RT intervention support, at best, a preventive effect against the increasing risk of bone frailty in an older population, which is evident beyond 12 weeks of RT practice engagement.

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“…In the same study, both Denosumab and Teriparatide treatment effected similar changes in trabecular vBMD (7.7 mg/cm 3 Denosumab and 6.2 mg/cm 3 Teriparatide), while the effect on cortical vBMD was very different between groups (14.9 mg/cm 3 Denosumab and -8.0 mg/cm 3 Teriparatide) (Figure 2). We have recently demonstrated excellent repeatability of vBMD and femoral neck strength from 3D-DXA analyses of pairs of same-day repeated proximal femur scans from 10 healthy women [7] . We also showed that mean bone accrual following 8 months of bone-targeted exercise using 3D-DXA Hip analysis exceeded repeatability values in the femoral neck and cortical regions.…”

Section: Ability Of 3d-dxa To Analyse the Cortex From Dxa Scansmentioning

confidence: 97%

Response to “Concerns regarding the use of 3D-DXA”

Beck¹,

Harding²,

Weeks³

et al. 2021

Bone

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Assessment of femoral neck strength and bone mineral density changes following exercise using 3D-DXA images

Cited by 13 publications

References 34 publications

Statistical Shape and Appearance Models: Development Towards Improved Osteoporosis Care

Statistical Shape and Appearance Models: Development Towards Improved Osteoporosis Care

The Effect of Resistance Training on Bone Mineral Density in Older Adults: A Systematic Review and Meta-Analysis

Response to “Concerns regarding the use of 3D-DXA”

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