Assessment of expression of oxytocin-related lncRNAs in schizophrenia

Eghtedarian, Reyhane; Akbari, Mohammadarian; Badrlou, Elham; Hussen, Bashdar Mahmud; Eslami, Solat; Akhavan-Bahabadi, Mehdi; Taheri, Mohammad; Ghafouri‐Fard, Soudeh; Neishabouri, Seyedeh Morvarid

doi:10.1016/j.ejphar.2022.175205

Cited by 1 publication

(1 citation statement)

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“…Furthermore, another research has illustrated that XBP1 can regulate macrophage cGAS/STING/NLRP3 activation via elevating macrophage self-mtDNA cytosolic leakage in liver fibrosis. Therefore, macrophage self-mtDNA can play an effective role as an intrinsic trigger for macrophage cGAS/STING activation that can be modulated through regulating XBP1/mitophagy ( 13 ).…”

Section: Gastrointestinal I/r Injurymentioning

confidence: 99%

NLRP3: Role in ischemia/reperfusion injuries

et al. 2022

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NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome. This protein acts as a pattern recognition receptor identifying pathogen-associated molecular patterns. In addition to recognition of pathogen-associated molecular patterns, it recognizes damage-associated molecular patterns. Triggering of NLRP3 inflammasome by molecules ATP released from injured cells results in the activation of the inflammatory cytokines IL-1β and IL-18. Abnormal activation of NLRP3 inflammasome has been demonstrated to stimulate inflammatory or metabolic diseases. Thus, NLRP3 is regarded as a proper target for decreasing activity of NLRP3 inflammasome. Recent studies have also shown abnormal activity of NLRP3 in ischemia/reperfusion (I/R) injuries. In the current review, we have focused on the role of this protein in I/R injuries in the gastrointestinal, neurovascular and cardiovascular systems.

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Section: Gastrointestinal I/r Injurymentioning

confidence: 99%