Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach

Ottenbros, Ilse; Lebret, Erik; Huber, Carolin; Lommen, Arjen; Antignac, Jean-Philippe; Čupr, Pavel; Šulc, Libor; Mikeš, Ondřej; Szigeti, Tamás; Középesy, Szilvia; Mārtiņsone, Inese; Martinsone, Žanna; Akūlova, Lāsma; Pardo, Olga; Fernández, Sandra F.; Coscollà, Clara; Pedraza-Dı́az, Susana; Krauß, Martin; Debrauwer, Laurent; Wagner, Kévin; Nijssen, Rosalie; Mol, Hans; Vitale, Chiara Maria; Klánová, Jana; Molina, Borja Garlito; León, Núria; Vermeulen, Roel; Luijten, Mirjam; Vlaanderen, Jelle

doi:10.1016/j.ijheh.2022.114105

Cited by 17 publications

(4 citation statements)

References 41 publications

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“…Although their association with childhood cancer has not been fully demonstrated, we found that more than 80% of the epidemiological studies show positive associations with this disease ( Table 3 , Figure 5 ). A recent study that evaluated pesticides in the urine samples of parents and children from five European countries reported that 84% of samples showed at least two pesticides, highlighting the global exposure to these chemicals [ 195 ]. Unfortunately, most of these studies lack the characterization and quantification of pesticides in the human body, and generally rely only on self-reported uses.…”

Section: Discussionmentioning

confidence: 99%

“…Different classes of pesticides have been associated with childhood cancer, including organochlorides, organophosphates, and pyrethroids (Table 3). Regulatory agencies have considered several pesticides as carcinogens, such as DDT, but, for many others, such as pyrethroids, the evidence has not been enough to be catalogued as carcinogens [195]. The mechanisms underlying the associations of pesticides with childhood cancer may be different according to the type of pesticides.…”

Section: Pesticidesmentioning

confidence: 99%

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Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade

Navarrete-Meneses,

Salas-Labadía,

Gómez-Chávez

et al. 2024

IJMS

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The long-term effects of environmental pollution have been of concern as several pollutants are carcinogenic, potentially inducing a variety of cancers, including childhood cancer, which is a leading cause of death around the world and, thus, is a public health issue. The present scoping review aimed to update and summarize the available literature to detect specific environmental pollutants and their association with certain types of childhood cancer. Studies published from 2013 to 2023 regarding environmental pollution and childhood cancer were retrieved from the PubMed database. A total of 174 studies were eligible for this review and were analyzed. Our search strategy brought up most of the articles that evaluated air pollution (29%) and pesticides (28%). Indoor exposure to chemicals (11%), alcohol and tobacco use during pregnancy (16%), electromagnetic fields (12%), and radon (4%) were the subjects of less research. We found a particularly high percentage of positive associations between prenatal and postnatal exposure to indoor (84%) and outdoor (79%) air pollution, as well as to pesticides (82%), and childhood cancer. Positive associations were found between leukemia and pesticides and air pollution (33% and 27%); CNS tumors and neuroblastoma and pesticides (53% and 43%); and Wilms tumor and other rare cancers were found in association with air pollution (50%). Indoor air pollution was mostly reported in studies assessing several types of cancer (26%). Further studies are needed to investigate the mechanisms underlying the potential associations between indoor/outdoor air pollution and pesticide exposure with childhood cancer risk as more preventable measures could be taken.

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Section: Discussionmentioning

confidence: 99%

Section: Pesticidesmentioning

confidence: 99%

Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade

Navarrete-Meneses,

Salas-Labadía,

Gómez-Chávez

et al. 2024

IJMS

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“…Pesticides are used to prevent, repel, destroy, or control pests or to regulate plant growth (Wu et al, 2022). They are typically ingested by humans through a variety of routes, including diet, occupational, and environmental exposure (Ottenbros et al, 2023). Organochlorine pesticides (OCPs) cause epigenetic changes (Rafeeinia et al, 2023), endocrine dysfunction, congenital disabilities, cancer, immunosuppression, reproductive abnormalities, and neurological disorders (Arisekar et al, 2022).…”

Section: Targetmentioning

confidence: 99%

Evaluation of food μPADs with the new tech perspectives and future prospects

Okutan Arslan,

Trabzon

2023

eFood

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Food microfluidic paper‐based analytical devices (µPADs) are powerful tools to create total analysis systems and have long been demonstrated to be useful for safety and quality applications. Thanks to new technological innovations food µPADs offer exciting new possibilities. This review introduces how µPADs are obtained from chromatography, filter, or office papers and detect analytes from a food sample. We introduce the most current developments in the use of µPADs with an emphasis on paper types, adapted new technologies, and detection limits. Classifications are also made on food µPADs according to applied innovations and adapted novel technologies. In the first section, simple forms of µPADs for the detection of pathogen, mycotoxin, pesticides, and other food components are discussed with technical details. Then, we introduce multisensing approaches for high throughput analysis and a concise summary will be given. In the case of three‐dimensional (3D) µPADs, the use of 3D is discussed and compared to 2D µPADs in terms of its advantageous with the example of a food colorant test device. In the following section, smartphone adoption to µPADs is introduced in detail with eight different assay examples. Centrifugal platform for nickel assay is demonstrated as an enabling approach with shortened assay times by rotational velocity. The potential of user‐friendly hybrid devices is also summarized in the last part. Finally, we present an outlook to underline the opportunities created by smartphone‐based and intelligent µPADs for food safety and quality with real success perspectives

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“…11,30,31 Furthermore, the herbicide 2,4-D is used on pastures and, sometimes, soccer fields, and synthetic pyrethroid insecticides are used for vector control in the home environment. 32 These pesticides are commonly used worldwide, [33][34][35][36] although in 2020, the use of both chlorpyrifos and mancozeb was not renewed in the European Union 37,38 due to concerns regarding neurodevelopmental toxicity, 39 reprotoxic, and endocrine disrupting effects, 40 respectively. Also, the United States Environmental Protection Agency has published requests for the voluntary cancellation of chlorpyrifos products and to end food use.…”

Section: Introductionmentioning

confidence: 99%

Pesticide exposure, birth size, and gestational age in the ISA birth cohort, Costa Rica

van Wendel de Joode,

Peñaloza-Castañeda,

Mora

et al. 2024

Environmental Epidemiology

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Purpose: To examine associations of prenatal biomarkers of pesticide exposure with birth size measures and length of gestation among newborns from the Infants’ Environmental Health (ISA) birth cohort, Costa Rica. Methods: We included 386 singleton liveborn newborns with data on birth size measures, length of gestation, and maternal urinary biomarkers of chlorpyrifos, synthetic pyrethroids, mancozeb, pyrimethanil, and 2, 4-D during pregnancy. We associated biomarkers of exposure with birth outcomes using multivariate linear regression and generalized additive models. Results: Concentrations were highest for ethylene thiourea (ETU, metabolite of mancozeb), median = 3.40; p10–90 = 1.90–6.79 µg/L, followed by 3,5,6-trichloro-2-pyridinol (TCP, metabolite of chlorpyrifos) p50 = 1.76 p10–90 = 0.97–4.36 µg/L, and lowest for 2,4-D (p50 = 0.33 p10–90 = 0.18–1.07 µg/L). Among term newborns (≥37 weeks), higher prenatal TCP was associated with lower birth weight and smaller head circumference (e.g., β per 10-fold-increase) during the second half of pregnancy = −129.6 (95% confidence interval [CI] = −255.8, −3.5) grams, and −0.61 (95% CI = −1.05, −0.17) centimeters, respectively. Also, among term newborns, prenatal 2,4-D was associated with lower birth weight (β per 10-fold-increase = −125.1; 95% CI = −228.8, −21.5), smaller head circumference (β = −0.41; 95% CI = −0.78, −0.03), and, during the second half of pregnancy, with shorter body length (β = −0.58; 95% CI = −1.09, −0.07). Furthermore, ETU was nonlinearly associated with head circumference during the second half of pregnancy. Biomarkers of pyrethroids and pyrimethanil were not associated with birth size, and none of the biomarkers explained the length of gestation. Conclusions: Prenatal exposure to chlorpyrifos and 2,4-D, and, possibly, mancozeb/ETU, may impair fetal growth.

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Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach

Cited by 17 publications

References 41 publications

Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade

Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade

Evaluation of food μPADs with the new tech perspectives and future prospects

Pesticide exposure, birth size, and gestational age in the ISA birth cohort, Costa Rica

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