Assessment of Exposure to Di-(2-ethylhexyl) Phthalate (DEHP) Metabolites and Bisphenol A (BPA) and Its Importance for the Prevention of Cardiometabolic Diseases

Carli, Fabrizia; Ciociaro, Demetrio; Gastaldelli, Amalia

doi:10.3390/metabo12020167

Cited by 15 publications

(15 citation statements)

References 91 publications

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“…Limit of Detection and Quantification (LOD and LOQ) were determined according to IUPAC guidance and US Environmental Protection Agency (https://www.epa.gov/cwa-methods/procedures-detection-and-quantitation-documents). We found that LOD and LOQ were for MEHP 0.28 and 0.58 ng/ml, for MEOHP 0.18 and 0.48 ng/ml and for MEHHP 0.11 and 0.24 ng/ml, respectively (Carli et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

“…Information on background levels, blank and spike recoveries, calibration curves and quality control samples are reported in (Carli et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

“…Both analytical methods used to determine DEHP metabolites and BPA were validated in a proficiency test (ICI/EQUAS) in the frame of the HBM4EU Project (https://www.hbm4eu.eu/online-library/), as previously reported (Carli et al, 2022).…”

Section: Determination Of Bpa Levelsmentioning

confidence: 99%

“…After LC-MS analysis, samples were dried under a gentle nitrogen flux and then derivatizated with 10 µl of BSTFA 1%TMCS and 50 µl of acetonitrile (Sigma Aldrich, Merck KGaA, Darmstadt, Germany (Carli et al, 2022). BPA analysis was performed by GCMS (7890A coupled with 5975 Agilent, Santa Clara CA) equipped with a capillary column (DB-5MS J&W, l 30 m; i.d.…”

Section: Determination Of Bpa Levelsmentioning

confidence: 99%

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Women exposure to Di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA) from different residing areas in Italy: data from the LIFE PERSUADED project

Carli

Tait

Busani

et al. 2022

Preprint

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Phthalates and bisphenol A (BPA) are plasticizers used in many industrial products that can act as endocrine disruptors. In the frame of the LIFE PERSUADED project, we measured the urinary concentrations of BPA and Di (2-ethylhexyl) phthalate (DEHP) metabolites in 900 Italian women enrolled between 2015 and 2017 and living in North, Centre and South of Italy in both rural and urban areas. The whole cohort, representative of the Italian female adult population, was exposed to DEHP and BPA with measurable levels above the limit of detection (LOD) in more than 99% and 95% of the samples, respectively. The exposure patterns differed for the two chemicals in the three macro-areas with the highest urinary levels for DEHP in South compared to Central and Northern Italy and for BPA in Northern compared to Central and Southern Italy. BPA levels were higher in women living in urban areas, whereas no difference between areas was observed for DEHP. The estimated daily intake of BPA was 0.11 μg/kg per day, about 36-fold below the current temporary Tolerable Daily Intake of 4 μg/kg per day established by the European Food Safety Authority in 2015. The analysis of cumulative exposure showed a positive correlation between DEHP and BPA. These results suggest to further limit the exposure to DEHP and BPA through specific legislative measures.

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Section: Methodsmentioning

confidence: 99%

“…Information on background levels, blank and spike recoveries, calibration curves and quality control samples are reported in (Carli et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

Section: Determination Of Bpa Levelsmentioning

confidence: 99%

Section: Determination Of Bpa Levelsmentioning

confidence: 99%

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Women exposure to Di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA) from different residing areas in Italy: data from the LIFE PERSUADED project

Carli

Tait

Busani

et al. 2022

Preprint

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“…Chemical bonds of xenoestrogens with plasma carrier proteins have significantly lower affinity. In natural estrogens, this affinity is much better, so they are more easily accessible to target organs [2,[26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Proteolytic processes in organism of different age rats exposed to xenoestrogens

Lykholat

Marenkov

et al. 2022

J. Phys.: Conf. Ser.

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Endocrine disrupting chemicals (EDCs) are a group of compounds that affect the endocrine system, frequently found in everyday products and epidemiologically associated with several diseases. The human population is now ubiquitously exposed to EDCs in daily life. The main way of getting xenoestrogens to the body is the contaminated food. The effects of xenoestrogens on the proteolytic processes of different age rats were determination. The experiments were conducted on Wistar rats exposed to exogenous estrogen for 45 days. At the beginning of the experiment 3-month-old pubertal animals and 6-month-old sexually mature rats were involved. The research materials were organ tissue and blood serum of the rats. The objects were indexes of activity of trypsin and its obligatory inhibitors α1 - antitrypsin (α1-AT) and α2-macroglobulin (α2-MG), cysteine cathepsins B and L, the molecules of middle mass (MMM) level. In summary, the eating food contaminated by exoestrogens led to changes in the proteolytic system and the development of endogenous intoxication, which are also organ-specific and dependent on the age of the animals: a higher level of activity of the inhibitory link and the content of MMM was observed in rats in the puberty period, which leads to a decrease in the potential of the protective mechanisms of the organism and can become a trigger dysfunctional systems of natural detoxification and biotransformation. Inhibition of apoptosis is the main consequence found in the body of experimental rats. This phenomenon can lead to processes that inhibit one of the main mechanisms that reject damaged cells from the population. Females who were in puberty were more susceptible to dietary synthetic estrogens. In contrast to adult animals of the same sex, whose indicators indicate the importance of age characteristics of the body for the ability to perceive the effects of xenoestrogens. Rats became less sensitive to the effects of these substances with age. The diference in experimental animals was due to changes in the rate of detoxification pathway reactions, and not in the metabolism of estrogens entering the body, in particular, with food.

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Design and simulation of photonic crystal fibre sensor for harmful chemicals detection in polycarbonate plastics

Maidi,

Salam,

Kalam

et al. 2023

Opt Quant Electron

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Assessment of Exposure to Di-(2-ethylhexyl) Phthalate (DEHP) Metabolites and Bisphenol A (BPA) and Its Importance for the Prevention of Cardiometabolic Diseases

Cited by 15 publications

References 91 publications

Women exposure to Di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA) from different residing areas in Italy: data from the LIFE PERSUADED project

Women exposure to Di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA) from different residing areas in Italy: data from the LIFE PERSUADED project

Proteolytic processes in organism of different age rats exposed to xenoestrogens

Design and simulation of photonic crystal fibre sensor for harmful chemicals detection in polycarbonate plastics

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