“…Fructose injection leads to phosphorylation of fructose to fructose‐1‐phosphate, resulting in immediate PME increases and reductions of ATP and Pi levels that partly resolve over the next hour (67, 68). Patients with cirrhosis, hereditary glucose intolerance or jaundice exhibited little or no response (68–70), while patients with non‐alcoholic steatohepatitis showed an impaired recovery of ATP level (71). Alanine infusion stimulates gluceogenesis leading to increased levels of hepatic phosphorylated glucose intermediates such as (the PME) glucose‐6‐phosphate.…”