Assessment of endothelial function in patients with nonalcoholic fatty liver disease

Çolak, Yaşar; Şenateş, Ebubekir; Yeşıl, Atakan; Yılmaz, Yusuf; Öztürk, Oğuzhan; Doganay, Levent; Çoşkunpınar, Ender; Kahraman, Özlem Tımırcı; Mesçi, Banu; Ulasoglu, Celal; Tuncer, İlyas

doi:10.1007/s12020-012-9712-1

Cited by 74 publications

(64 citation statements)

References 38 publications

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“…23 In the studies by Colak et al, C-IMT was found to be significantly higher in patients with NAFLD group (P< 0.001). 24 Limitations of the study was that the sample size is small. A larger sample size could have provided a greater statistical power and permitted more complete adjustment for potential confounders.…”

Section: Resultsmentioning

confidence: 97%

Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus and its correlation with coronary artery disease (CAD)

et al. 2017

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Background: Non-alcoholic fatty liver disease (NAFLD) is a common association of Type 2 diabetes mellitus and diabetes mellitus is a leading risk factor for coronary artery disease (CAD). This study aims at estimating the prevalence of NAFLD by ultrasonography and to correlate NAFLD with CAD in a group of patients with Type 2 DM.Methods: Consecutive patients of Type 2 diabetes fulfilling the inclusion criteria were recruited. Clinical and biochemical parameters were recorded. NAFLD was diagnosed by ultrasonography.Results: The prevalence of NAFLD was 41.2% in the study group (n=114) and was higher in females. Prevalence of NAFLD in the younger age group was significantly higher than that in the older age group. Elevated liver enzymes, elevated HbA1C, duration of diabetes, obesity, acanthosis nigricans and metabolic syndrome were all significantly associated with NAFLD. CAD was significantly higher in the NAFLD subgroup (72.46%) compared to the non-NAFLD subgroup (52.63%) (p=0.001). Using binary logistic regression analysis, it was found that NAFLD is an independent predictor of CAD (p=0.002).Conclusions: NAFLD is extremely common in people with Type 2 diabetes and is associated with a higher prevalence of CAD.NAFLD is an independent risk factor for development of CAD. Thus, identification of NAFLD in diabetics might help in predicting the risk of CAD and to adopt the necessary preventive strategy.

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Section: Resultsmentioning

confidence: 97%

Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus and its correlation with coronary artery disease (CAD)

et al. 2017

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“…Some authors have reported data demonstrating that no significant difference between NAFLD and control patients occurs in serum ADMA concentration [38,39]. Others have reported the opposite.…”

Section: Discussionmentioning

confidence: 99%

MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters

et al. 2016

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Using an experimental model of NASH induced by a methionine-choline-deficient (MCD) diet, we investigated whether changes occur in serum and tissue levels of asymmetric dimethylarginine (ADMA). Male Wistar rats underwent NASH induced by 8-week feeding with an MCD diet. Serum and hepatic biopsies at 2, 4 and 8 weeks were taken, and serum enzymes, ADMA and nitrate/nitrite (NOx), were evaluated. Hepatic biopsies were used for mRNA and protein expression analysis of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) and protein methyltransferases (PRMT-1), enzymes involved in ADMA metabolism and synthesis, respectively, and ADMA transporters (CAT-1, CAT-2A and CAT-2B). Lipid peroxides (TBARS), glutathione, ATP/ADP and DDAH activity were quantified. An increase in serum AST and ALT was detected in MCD animals. A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet. An increase in serum NOx and no changes in protein expression in DDAH-1 and CAT-1 and higher content in CAT-2 and PRMT-1 were found at 8 weeks. Hepatic DDAH activity decreased with a concomitant increase in oxidative stress, as demonstrated by high TBARS levels and low glutathione content. In conclusion, a decrease in serum and tissue ADMA levels in the MCD rats was found associated with a reduction in DDAH activity due to the marked oxidative stress observed. Changes in ADMA levels and its transporters are innovative factors in the onset and progression of hepatic alterations correlated with MCD diet-induced NASH.

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“…As opposed to VTE, the process leading to arterial thrombosis in these patients appears to be considerably more complex than a "hypercoagulable status" with endothelial dysfunction as the common soil [43]. Indeed, it is driven by a convergence of risk factors.…”

Section: Arterial Thrombosismentioning

confidence: 98%

Is there a rationale for treatment of chronic liver disease with antithrombotic therapy?

2015

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Assessment of endothelial function in patients with nonalcoholic fatty liver disease

Cited by 74 publications

References 38 publications

Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus and its correlation with coronary artery disease (CAD)

Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus and its correlation with coronary artery disease (CAD)

MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters

Is there a rationale for treatment of chronic liver disease with antithrombotic therapy?

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