Assessment of endoscopic response using pan-enteric capsule endoscopy in Crohn’s disease; the Sensitivity to Change (STOC) study

Patients diagnosed with Crohn’s disease are increasingly subjected to repeat colonoscopic and radiological examinations to assess the extent of the disease severity and the effects of treatment. PillcamTM Crohn’s video capsule, a modified colon capsule, was developed to generate a minimally invasive mouth to rectum video of the gastrointestinal tract. The capsule provides a wide-angle panoramic mucosal view to assess inflammation, ulceration, stenosis, disease extent, and effect of treatment. This review summarizes the evidence of its utility in both adult and paediatric Crohn’s disease and reviews the scoring systems used to quantify findings. The literature survey indicates that the PillcamTM Crohn’s capsule offers high sensitivity and specificity for the detection of inflammatory lesions and the extent and distribution of disease, and it could be considered a reliable imaging modality in both adults and childhood with Crohn’s disease.

show abstract

“…There were also no adverse events. The authors concluded that PCC is useful to assess changes in mucosal disease activity in CD patients [17].…”

Section: Panenteric Capsule Endoscopy In Adults With Inflammatory Bow...mentioning

confidence: 99%

Is Panenteric PillcamTM Crohn’s Capsule Endoscopy Ready for Widespread Use? A Narrative Review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Volkers et al explored the endoscopic response to infliximab in 22 patients using PCC. They gave the capsule before, 8 and 12 weeks after treatment; as a result, 27% of patients observed endoscopic remission and another 50% observed endoscopic response [ 86 ]. Similarly, a prospective study of patients treated with Vedolizumab undergoing a PCC exam (before treatment initiation, week 14 and 52 of therapy) is being currently conducted [ 87 ].…”

Section: Monitoringmentioning

confidence: 99%

Video Capsule Endoscopy Plays an Important Role in the Management of Crohn’s Disease

Levartovsky

Eliakim

2023

Diagnostics

View full text Add to dashboard Cite

Crohn’s disease (CD) is a chronic inflammatory disorder characterized by a transmural inflammation that may involve any part of the gastrointestinal tract. An evaluation of small bowel involvement, allowing recognition of disease extent and severity, is important for disease management. Current guidelines recommend the use of capsule endoscopy (CE) as a first-line diagnosis method for suspected small bowel CD. CE has an essential role in monitoring disease activity in established CD patients, as it can assess response to treatment and identify high-risk patients for disease exacerbation and post-operative relapse. Moreover, several studies have shown that CE is the best tool to assess mucosal healing as part of the treat-to-target strategy in CD patients. The PillCam Crohn’s capsule is a novel pan-enteric capsule which enables visualization of the whole gastrointestinal tract. It is useful to monitor pan-enteric disease activity, mucosal healing and accordingly allows for the prediction of relapse and response using a single procedure. In addition, the integration of artificial intelligence algorithms has showed improved accuracy rates for automatic ulcer detection and the ability to shorten reading times. In this review, we summarize the main indications and virtue for using CE for the evaluation of CD, as well as its implementation in clinical practice.

show abstract

Updates in the diagnosis and management of small-bowel Crohn's disease

Carretero

Bojórquez

Eliakim

et al. 2023

Best Practice & Research Clinical Gastroenterology

View full text Add to dashboard Cite

Assessment of endoscopic response using pan-enteric capsule endoscopy in Crohn’s disease; the Sensitivity to Change (STOC) study

Cited by 3 publications

References 27 publications

Is Panenteric PillcamTM Crohn’s Capsule Endoscopy Ready for Widespread Use? A Narrative Review

Is Panenteric PillcamTM Crohn’s Capsule Endoscopy Ready for Widespread Use? A Narrative Review

Video Capsule Endoscopy Plays an Important Role in the Management of Crohn’s Disease

Updates in the diagnosis and management of small-bowel Crohn's disease

Contact Info

Product

Resources

About