Assessment of ejection fraction and heart perfusion using myocardial perfusion single-photon emission computed tomography in Finland and Estonia: a multicenter phantom study

Ronkainen, Ari-Petteri; Eneh, Chibuzor; Linder, Pia; Hippeläinen, Eero; Heikkinen, Jari

doi:10.1097/mnm.0000000000001234

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…7 Department of Image and Functional Medicin, Central Hospital, Karlstad, Sweden. 8 Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden. 9…”

Section: Discussionmentioning

confidence: 99%

“…The pre-measurement preparation that needs to be performed on site could introduce additional uncertainties [5]. Nevertheless, physical phantoms have been used in several multicentre studies by Heikinnen [6][7][8]. In equivalence to physical phantom studies, results obtained from image data analysis based on MC-simulations can be compared to a known truth.…”

Section: Introductionmentioning

confidence: 99%

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A multicentre simulation study of planar whole-body bone scintigraphy in Sweden

Gustafsson

Örndahl²,

Minarik

et al. 2022

EJNMMI Phys

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Background Whole-body bone scintigraphy is a clinically useful non-invasive and highly sensitive imaging method enabling detection of metabolic changes at an early stage of disease, often earlier than with conventional radiologic procedures. Bone scintigraphy is one of the most common nuclear medicine methods used worldwide. Therefore, it is important that the examination is implemented and performed in an optimal manner giving the patient added value in the subsequent care process. The aim of this national multicentre survey was to investigate Swedish nuclear medicine departments compliance with European practice guidelines for bone scintigraphy. In addition, the effect of image acquisition parameters on the ability to detect metabolic lesions was investigated. Methods Twenty-five hospital sites participated in the study. The SIMIND Monte Carlo (MC) simulation and the XCAT phantom were used to simulate ten fictive patient cases with increased metabolic activity distributed at ten different locations in the skeleton. The intensity of the metabolic activity was set into six different levels. Individual simulations were performed for each site, corresponding to their specific camera system and acquisition parameters. Simulated image data sets were then sent to each site and were visually evaluated in terms of if there was one or several locations with increased metabolic activity relative to normal activity. Result There is a high compliance in Sweden with the EANM guidelines regarding image acquisition parameters for whole-body bone scintigraphy. However, up to 40% of the participating sites acquire lower count density in the images than recommended. Despite this, the image quality was adequate to maintain a stable detection level. None of the hospital sites or individual responders deviated according to the statistical analysis. There is a need for at least 2.5 times metabolic activity compared to normal for a lesion to be detected. Conclusion The imaging process is well harmonized throughout the country and there is a high compliance with the EANM guidelines. There is a need for at least 2.5 times the normal metabolic activity for a lesion to be detected as abnormal.

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“…7 Department of Image and Functional Medicin, Central Hospital, Karlstad, Sweden. 8 Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden. 9…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A multicentre simulation study of planar whole-body bone scintigraphy in Sweden

Gustafsson

Örndahl²,

Minarik

et al. 2022

EJNMMI Phys

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Performance evaluation of a novel multi-pinhole collimator on triple-NaI-detector SPECT/CT for dedicated myocardial imaging

et al. 2023

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Background In this study we evaluated the imaging capabilities of a novel Multi-pinhole collimator (MPH-Cardiac) specially designed for nuclear cardiology imaging on a Triple-NaI-detector based SPECT/CT system. Methods 99mTc point source measurements covering the field of view (FOV) were used to determine tomographic sensitivity (TSpointsource) and spatial resolution. Organ-size tomographic sensitivity (TSorgan) was measured with a left ventricle (LV) phantom filled with typical myocardial activity of a patient scan. Reconstructed image uniformity was measured with a 140 mm diameter uniform cylinder phantom. Using the LV phantom once filled with 99mTc and after with 123I, Contrast-to-noise ratio (CNR) was measured on the reconstructed images by ROI analysis on the myocardium activity and on the LV cavity. Furthermore, a polar map analysis was performed determining Spill-Over-Ratio in water (SORwater) and image noise. The results were compared with that of a dual-head parallel-hole low energy high resolution (LEHR) collimator system. A patient with suspected coronary artery disease (CAD) was scanned on the LEHR system using local protocol of 16 min total acquisition time, followed by a 4-min MPH-Cardiac scan. Results Peak TSpointsource was found to be 1013 cps/MBq in the axial center of the FOV while it was decreasing toward the radial edges. TSorgan in the CFOV was found to be 134 cps/MBq and 700 cps/MBq for the LEHR and MPH-Cardiac, respectively. Average spatial resolution throughout the FOV was 4.38 mm FWHM for the MPH-Cardiac collimator. Reconstructed image uniformity values were found to be 0.292% versus 0.214% for the LEHR and MPH-Cardiac measurements, respectively. CNR was found to be higher in case of MPH-Cardiac than for LEHR in case of 99mTc (15.5 vs. 11.7) as well as for 123I (13.5 vs. 8.3). SORwater values were found to be 28.83% and 21.1% for the 99mTc measurements, and 31.44% and 24.33% for the 123I measurements for LEHR and MPH-Cardiac, respectively. Pixel noise of the 99mTc polar maps resulted in values of 0.38% and 0.24% and of the 123I polar maps 0.62% and 0.21% for LEHR and MPH-Cardiac, respectively. Visually interpreting the patient scan images, MPH-Cardiac resulted in better image contrast compared to the LEHR technique with four times shorter scan duration. Conclusions The significant image quality improvement achieved with dedicated MPH-Cardiac collimator on triple head SPECT/CT system paves the way for short acquisition and low-dose cardiovascular SPECT applications.

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Performance Evaluation of a Novel Multi-PinHole Collimator on Triple-detector SPECT/CT for dedicated myocardial imaging

Krizsán¹,

Kukuts²,

Al-Muhanna³

et al. 2022

Preprint

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BackgroundIn this study we evaluated the imaging capabilities of a novel Multi-pinhole collimator (MPH-Cardiac) specially designed for nuclear cardiology imaging on a triple head NaI(Tl) detector based SPECT/CT system.Methods99mTc point source measurements covering the field-of-view (FOV) were used to determine tomographic sensitivity (TSpointsource) and spatial resolution. Organ-size tomographic sensitivity (TSorgan) was measured with a left ventricle (LV) phantom filled with typical myocardial activity of a patient scan. Reconstructed image uniformity was measured with a 140 mm diameter uniform cylinder phantom. Using the LV phantom once filled with 99mTc and after with 123I, a polar map analysis was performed determining Spill-Over-Ratio in water (SORwater) and image noise. Results were compared with that of a dual-head parallel-hole low energy high resolution (LEHR) collimator system. A patient with suspected coronary artery disease (CAD) was scanned on the LEHR system using local protocol of 16 minutes total acquisition time, followed by a 4-minute MPH-Cardiac scan. ResultsPeak TSpointsource was found to be 1013 cps/MBq in the axial center of the FOV while it was decreasing towards the radial edges. TSorgan in the CFOV was found to be 134 cps/MBq and 700 cps/MBq for the LEHR and MPH-Cardiac respectively. Average spatial resolution throughout the FOV was 4.38 mm FWHM for the MPH-Cardiac collimator. Reconstructed image uniformity values were found to be 0.504 % versus 0.392 % for the LEHR and MPH-Cardiac measurements respectively. SORwater values were found to be 28.83% and 21.1 % for the 99mTc measurements, and 31.44 % and 24.33 % for the 123I measurements for LEHR and MPH-Cardiac respectively. Pixel noise of the 99mTc polar maps resulted in values of 0.38 % and 0.24 % and of the 123I polar maps 0.62 % and 0.21 % for LEHR and MPH-Cardiac respectively. Visually interpreting the patient scan images, MPH-Cardiac resulted in better image contrast compared to the LEHR technique with four times shorter scan duration.ConclusionsThe significant image quality improvement achieved with dedicated MPH-Cardiac collimator on triple head SPECT/CT system paves the way for short acquisition and low-dose cardiovascular SPECT applications.

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Assessment of ejection fraction and heart perfusion using myocardial perfusion single-photon emission computed tomography in Finland and Estonia: a multicenter phantom study

Cited by 4 publications

References 19 publications

A multicentre simulation study of planar whole-body bone scintigraphy in Sweden

A multicentre simulation study of planar whole-body bone scintigraphy in Sweden

Performance evaluation of a novel multi-pinhole collimator on triple-NaI-detector SPECT/CT for dedicated myocardial imaging

Performance Evaluation of a Novel Multi-PinHole Collimator on Triple-detector SPECT/CT for dedicated myocardial imaging

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