Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits

Günay, Yusuf; Tütüncü, Tanju; Öcalan, Tuba; Bi̇lgi̇han, Ayşe; Korkmaz, Gülcan Güntaş; Kama, Nuri Aydın

doi:10.4274/haseki.galenos.2019.4752

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…It has a large financial burden on the healthcare economy, and GDs are influenced by an interaction of complicated environmental and genetic factors [ 12 ]. About 10%–15% of the global adult population is influenced by GDs because it is a highly prevalent gastroenterological disorder [ 13 , 14 ]. It is not lethal, but it can result in severe GIT disorders leading to many serious complications and outcomes, such as pancreatitis, gallbladder cancer, and acute GSs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Osteopontin (SPP1) expression on gallstone formation in rabbits fed with a lithogenic diet

Abdal,

Naemi

2023

J Adv Vet Anim Res

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Objective: This research was designed to assess the influence of the administration of a lithogenic diet, hydrogen peroxide, and vitamin AD3E on rabbits’ gallstone formation and to envisage the expression of osteopontin (OPN) in their hepatic tissues. Materials and Methods: Twenty-four healthy local mature rabbits of both genders were divided into four equal groups. At the end of the feeding period, samples of blood were taken from all rab¬bits after they had fasted overnight to estimate the serum lipid profile. And some of the hepatic tissue has been preserved at −28°C for molecular analysis and gene expression. Results: The gallstones were formed 100% in the GIII and 50% in the GIV. The mRNA OPN expression showed a significant increase in the GIII when compared with other groups. In Groups III and II, the serum levels of total cholesterol, Triglyceride, L-C, low-density lipoprotein-choles, and VLDL-C were significantly increased when compared with GI, while in GIII, the serum level of high-density lipoprotein-cholesterol was significantly decreased when compared with GI. Conclusion: It was concluded that the expression of the mRNA OPN was increased in the hepatic tissue of gallstone-formed rabbits.

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Section: Introductionmentioning

confidence: 99%

Osteopontin (SPP1) expression on gallstone formation in rabbits fed with a lithogenic diet

Abdal,

Naemi

2023

J Adv Vet Anim Res

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“…9 Animal model studies showed that thyroid dysfunction, either hypothyroidism or hyperthyroidism promotes the formation of cholesterol gallstones by different mechanisms. 10,11 But human studies showed that the gall stone formation was mainly attributed to the hypothyroid state. Hypothyroidism leads to super-saturation of the bile with cholesterol, gallbladder hypo-mobility, decreased contractility and impaired filling; this, in turn, allows enough time for nucleation, micelle formation and continuous growth into mature gallstones.…”

Section: Introductionmentioning

confidence: 99%

The role of routine thyroid assay in the management of gallstones

Idris¹,

S²

2021

IJCBR

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Background: Cholelithiasis is a type of biliary stone disease, with a high prevalence. Along with classic risk factors like obesity, weight loss, female sex hormones, age, an association with thyroid dysfunction has been established. Objectives: To evaluate the importance of thyroid profile as a diagnostic/therapeutic workup of gallstones. Materials and Methods: The study included 200 subjects, above 18 years. 100 subjects (50 males+50 females) had cholelithiasis confirmed by ultrasonography and remaining as 100 subjects(50males+50females) control group without gallstones. After a detailed history and clinical examination, blood samples were analyzed for TSH, T3 and T4, using Chemiluminescence-Immunoassay. Subjects with history of thyroid dysfunction or on thyroid replacement therapy, diabetes mellitus, pregnancy, drugs affecting thyroid hormone levels were excluded. Statistical analysis: Computing descriptive statistics was used. Any significant difference were tested using the unpaired sample student t-test. Result: The case group had a mean age of 45.70 ± 13.76 and the controls, a mean age of 38.78 ± 15.63. There was a significant increase in the prevalence of gallstones after the age of 40years, especially in females. 20% of cases were hypothyroid and 12% were hyperthyroid when compared to the controls which were 10% hypothyroid and 6% hyperthyroid. The higher prevalence of hypothyroid among cases was statistically significant. Among the hypothyroid cases, 80% had subclinical hypothyroidism. Conclusion:Our study concludes by saying that thyroid assay could be made a part of the diagnostic work up of gallstone management thus providing early detection for thyroid dysfunction and thus reducing the surgical/anesthetic complications.

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Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits

Cited by 2 publications

References 29 publications

Osteopontin (SPP1) expression on gallstone formation in rabbits fed with a lithogenic diet

Osteopontin (SPP1) expression on gallstone formation in rabbits fed with a lithogenic diet

The role of routine thyroid assay in the management of gallstones

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