Assessment of effects of phenolic fractions from leaves and petals of dandelion in selected components of hemostasis

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

“…In our previous in vitro studies, the standardized alcoholic fractions from petals and leaves of T. officinale (including HCAs and flavone fractions) were found to possess the ability to reduce oxidative stress (i.e., lipid peroxidation, protein carbonylation and protein thiol groups) in human plasma and blood platelets [3,21]. Additionally, dandelion fractions enriched with HCAs, derived from both leaves and petals, were shown to beneficially influence the coagulation activity of blood plasma [3].…”

“…Dandelion leaf and petal phenolic fractions, enriched with l-chicoric acid, are promising plant materials that may exert in vivo beneficial antioxidant effects.Antioxidants 2020, 9, 131 2 of 13 as thrombosis and atherosclerosis. Thus, preparations exerting both antioxidant and anticoagulant activities based on safe natural substances are continuously sought after for their potentially wide range of health benefits in the prevention and treatment of cardiovascular disorders [1][2][3][4][5][6][7].Nowadays, the dandelion (Taraxacum officinale) herb and root are used as a component of food products, dietary supplements and pharmacological preparations for various ailments (mainly liver, gallbladder and kidney disorders) [8,9]. This is due to a wide range of biological activities, including antihyperglycemic, antioxidant and anti-inflammatory actions demonstrated by dandelion fractions and their constituents, with no reported adverse effects, together with a well-understood chemical composition and a widespread occurrence of the plant throughout the world [10,11].…”

“…Natural bioactive substances with both antioxidative and hypo-cholesterolemic properties, an example of which is chicoric acid, have been found to be effective in preventing the formation and/or progression of atherosclerosis [18,22]. HCAs induce antiradical and protective actions against oxidation processes [3,21,23]; meanwhile, flavonoids inhibit the formation of reactive oxygen and/or nitrogen species by suppressing NO synthase and COX-2 protein expression [16,17,24].In our previous in vitro studies, the standardized alcoholic fractions from petals and leaves of T. officinale (including HCAs and flavone fractions) were found to possess the ability to reduce oxidative stress (i.e., lipid peroxidation, protein carbonylation and protein thiol groups) in human plasma and blood platelets [3,21]. Additionally, dandelion fractions enriched with HCAs, derived from both leaves and petals, were shown to beneficially influence the coagulation activity of blood plasma [3].With increasing evidence of the protective potential of dandelion fractions on the antioxidant status but with scarce data concerning its properties in the systemic vasculature, we aimed to examine whether dandelion fractions from leaves and petals influence, in the same way (i) the antioxidant profile (of internal organs, blood plasma and urine samples); (ii) modify the blood plasma lipids; (iii) glucose and (iv) the intestinal digesta.…”

“…Antioxidants 2020, 9, 131 2 of 13 as thrombosis and atherosclerosis. Thus, preparations exerting both antioxidant and anticoagulant activities based on safe natural substances are continuously sought after for their potentially wide range of health benefits in the prevention and treatment of cardiovascular disorders [1][2][3][4][5][6][7].…”

“…Natural bioactive substances with both antioxidative and hypo-cholesterolemic properties, an example of which is chicoric acid, have been found to be effective in preventing the formation and/or progression of atherosclerosis [18,22]. HCAs induce antiradical and protective actions against oxidation processes [3,21,23]; meanwhile, flavonoids inhibit the formation of reactive oxygen and/or nitrogen species by suppressing NO synthase and COX-2 protein expression [16,17,24].…”