Assessment of effectiveness of training of respiratory musculature in patients with chronic obstructive pulmonary disease and obesity

Ovsyannikov, Evgeniy; Сергеевич, Овсянников Евгений; Budnevsky, A. V.; Валериевич, Будневский Андрей; Shkatova, Yanina S.; Сергеевна, Шкатова Янина

doi:10.23888/pavlovj2019273367-374

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Хроническая обструктивная болезнь легких (ХОБЛ) является актуальной проблемой современного здравоохранения в силу высокой распространённости, значительного ограничения физической активности пациентов, снижения качества их жизни; обострения и ухудшения течения ХОБЛ являются одной из основных причин госпитализаций [1].…”

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Physical Weakness as Copd Phenotype

Kotlyarov¹,

Motynga²

2020

HMJ

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Chronic obstructive pulmonary disease (COPD) is an important cause of disability and premature death. The Global Strategy for the Diagnosis, Management and Prevention of COPD (GOLD) gives much attention to pulmonary rehabilitation programs including training of the muscles of the upper extremities and of respiratory muscles, which, in turn, permits to reliably reduce severity of clinical manifestations, to improve the quality of life, reduce the need for specialized medical care including outpatient visits to a doctor and the rate of exacerbations and hospitalizations for the given disease. One of the main problems of patients with this pathology is the syndrome of physical weakness. In these patients, disorders occur both in respiratory muscles and in mus-cles of the extremities, which reduces tolerance to physical exercise with the result of a consider-able impairment of the quality of life. Muscles of the lower extremities suffer to a higher extent than respiratory muscles and muscles of the upper extremities. According to foreign data, the cause of physical weakness is skeletal muscle dysfunction which leads not only to exercise intol-erance, but is also a predictor of increased mortality in COPD. Factors that contribute to muscle dysfunction are similar to those observed in a stable course of COPD: a significant role of nutritive support, hypercapnia, hypoxemia, electrolyte disorders, systemic inflammation. These factors may play a role of a triggering mechanism for a cascade of local inflammatory reactions and metabolic disorders that may induce different clinical effects including development of muscle dysfunction. At the moment, the problem of physical weakness as a consequence of muscle dysfunction in COPD deserves special study in order to effectively manage patients with this pathology in real clinical practice. Given the importance of the problem, a number of researchers have identified a separate phenotype of physical weakness in COPD. Identification of molecular mechanisms participating in muscle dysfunction, in loss of muscle mass and in disorders in anabolism will permit to elaborate new therapeutic goals in future.

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Physical Weakness as Copd Phenotype

Kotlyarov¹,

Motynga²

2020

HMJ

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The intensity of oxidative stress and systemic inflammation in patients with a combination of bronchial asthma and chronic obstructive pulmonary disease

et al. 2023

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Background. Chronic obstructive pulmonary disease and bronchial asthma, when combined in one patient, are characterized by a low level of control. Excess weight aggravates the course of obstructive diseases. The study of the features of this syntropy will improve the effectiveness of therapeutic measures. Aim. The study of the level of cytokines and carbonylated proteins in patients with a combination of bronchial asthma and chronic obstructive pulmonary disease with overweight and normal weight during an exacerbation. Material and methods. The study included 136 people: the first group a combination of bronchial asthma and chronic obstructive pulmonary disease (n=30), the second bronchial asthma (n=36), the third chronic obstructive pulmonary disease (n=29), the fourth volunteers without respiratory diseases (n=41). Each group was divided into two subgroups depending on the body mass index (less than 25 kg/m2 or 25 kg/m2 and more). The concentrations of interleukins-6 and -8, tumor necrosis factor in blood plasma were determined by enzyme immunoassay. The level of carbonylated plasma proteins was assessed spectrophotometrically. Statistical processing was performed in the Statistica 10.0 program using nonparametric criteria. The correlation of the studied parameters was assessed using the Spearman coefficient. Results. In patients with a combination of bronchial asthma and chronic obstructive pulmonary disease, statistically significant positive correlations between the levels of interleukins-6 and -8, tumor necrosis factor and carbonylated proteins were found 0.51, 0.59 and 0.55, respectively (p 0.05). Patients of the first group with overweight differed by 37.5% in higher levels of interleukin-6 compared with patients with body mass index 25 kg/m2. Conclusion. The intensity of systemic inflammation in patients with a combination of bronchial asthma and chronic obstructive pulmonary disease during exacerbation correlates with the intensity of oxidative damage.

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Assessment of effectiveness of training of respiratory musculature in patients with chronic obstructive pulmonary disease and obesity

Cited by 2 publications

References 12 publications

Physical Weakness as Copd Phenotype

Physical Weakness as Copd Phenotype

The intensity of oxidative stress and systemic inflammation in patients with a combination of bronchial asthma and chronic obstructive pulmonary disease

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