Assessment of dual inhibitory activity of epifriedelanol isolated from &lt;i&gt;Cayratia trifolia&lt;/i&gt; against ovarian cancer

Palanisamy, Chella Perumal; Sowmya, S; Velmurugan, D.; Sivaraman, Thirunavukkarasu; Gopalakrishnan, Vishrawas

doi:10.3329/bjp.v11i2.24933

Cited by 11 publications

(10 citation statements)

References 19 publications

(15 reference statements)

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“…It was performed in order to characterize the compounds on the basis of their ability to form favorable interactions within the active site of protein 16 The best active site (binding pocket/site) was determined based on the site score and hydrophobic/hydrophilic areas, which holds better binding cavity. 17 The binding site residues of CXCR4 were predicted and the results from this study showed that it may involve in the binding of substrate and small molecule. Thus, CXCR4 active site residues were picked to generate grid in the centroid of these residues for molecular docking approach.…”

Section: Adme Properties Predictionmentioning

confidence: 86%

Analysis of Novel C-X-C Chemokine Receptor Type 4 (CXCR4) Inhibitors from Hexane Extract of Euclea crispa (Thunb.) Leaves by Chemical Fingerprint Identification and Molecular Docking Analysis

Palanisamy¹,

Ashafa²

2018

JYP

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Objectives: To evaluate the potential inhibitors aginst CXCR4 from hexane extract of Euclea crispa (E. crispa) leaves. Methods: The natural compounds were identified and charecterized through GC-MS Analysis. Molecular docking studies carried out to investigatethe inhibitory activity angainst CXCR4. Absorption, Distribution, Metabolism, and Excretion (ADME) properties also were predicted to find pharmacokinetics and pharmacodynamics of compounds.Results:The molecular docking simulations revealed that, Benzoic acid 3-methyl-4-(1,3,3,3-tetrafluoro-2-methoxycarbonyl-propenylsulfanyl)-phenyl ester (SCHEMBL15979821), Hydrocortisone Acetate and Phenyl Glucuronide possess good inhibitory activites (Glide Score of -7.06, -6.97, -6.47 and Glide Energy of -43.22, -48.27 and -32.80 kcal/mol respectively) when compared with standard FDA approved drug and other compounds. All the screened compounds were within the acceptable and permissible limits of ADME properties. Conclusion: Thus, from this study it can be concluded that, these screened natural compounds from E. crispa leaves may serve as potential inhibitors for CXCR4 and they might lead to development of new therapeutic agents against cancer and its associated complications.Key words: E.crispa, GC-MS analysis, CXCR4, Molecular docking, ADME properties. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. Correspondence

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Section: Adme Properties Predictionmentioning

confidence: 86%

Analysis of Novel C-X-C Chemokine Receptor Type 4 (CXCR4) Inhibitors from Hexane Extract of Euclea crispa (Thunb.) Leaves by Chemical Fingerprint Identification and Molecular Docking Analysis

Palanisamy¹,

Ashafa²

2018

JYP

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“…Epi-friedelanol is present in several plants, such as in the root barks of Ulmus Davidiana [ 46 ], Cayratia trifolia [ 47 , 48 , 49 ], Vitis trifolia [ 50 ], Celtis sinensis [ 51 ], Mallotus apelta [ 52 ], and Ulmus pumila [ 53 ]. This triterpenoid has been reported to have anticancer [ 50 , 54 ], anti-inflammatory [ 51 ], and anti-senescence activity [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Yield, Characterization, and Possible Exploitation of Cannabis Sativa L. Roots Grown under Aeroponics Cultivation

et al. 2021

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Cannabis sativa L. has been used for a long time to obtain food, fiber, and as a medicinal and psychoactive plant. Today, the nutraceutical potential of C. sativa is being increasingly reappraised; however, C. sativa roots remain poorly studied, despite citations in the scientific literature. In this direction, we identified and quantified the presence of valuable bioactives (namely, β-sitosterol, stigmasterol, campesterol, friedelin, and epi-friedelanol) in the root extracts of C. sativa, a finding which might pave the way to the exploitation of the therapeutic potential of all parts of the C. sativa plant. To facilitate root harvesting and processing, aeroponic (AP) and aeroponic-elicited cultures (AEP) were established and compared to soil-cultivated plants (SP). Interestingly, considerably increased plant growth—particularly of the roots—and a significant increase (up to 20-fold in the case of β-sitosterol) in the total content of the aforementioned roots’ bioactive molecules were observed in AP and AEP. In conclusion, aeroponics, an easy, standardized, contaminant-free cultivation technique, facilitates the harvesting/processing of roots along with a greater production of their secondary bioactive metabolites, which could be utilized in the formulation of health-promoting and health-care products.

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“…Epi-friedelanol is present in several plants, such as in the root barks of Ulmus Davidiana [46], Cayratia trifolia [47][48][49], Vitis trifolia [50], Celtis sinensis [51], Mallotus apelta [52] and Ulmus pumila [53]. This triterpenoid has been reported to have anticancer [50,54], anti-inflammatory [51] and anti-senescence activity [46].…”

Section: Discussionmentioning

confidence: 99%

Yield, Characterization and Possible Exploitation of <em>Cannabis Sativa</em> L. Roots Grown Under Aeroponics Cultivation

Ferrini¹,

Fraternale²,

Zeppa³

et al. 2021

Preprint

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Cannabis Sativa L. has been used for a long time to obtain food, fiber and as a medicinal and psychoactive plant. Today the nutraceutical potential of C. Sativa is being increasingly reappraised; however, C. Sativa roots remain poorly studied, despite citations in the scientific literature. In this direction, we identified and quantified the presence of valuable bioactives (namely β-sitosterol, stigmasterol, campesterol, friedelin and epi-friedelanol) in the root extracts of C. Sativa, a finding which might pave the way to the exploitation of the therapeutic potential of C. Sativa in all its parts. To facilitate roots harvesting and processing, aeroponic (AP) and aeroponic elicited cultures (AEP), have been set up and compared to soil-cultivated plant (SP): interestingly a considerable overgrowth of the plants - particularly of roots - and a significant increase (up to 20 fold in the case of β-sitosterol) in the total content of the above roots’ bioactive molecules have been observed in AP and AEP. In conclusion aeroponics, an easy, standardised, free of contaminant cultivation tecchnique, allows an ease harvesting/processing of roots along with a greater production of their secondary bioactive metabolites which could be utilized in the formulation of health promoting and health care products.

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Assessment of dual inhibitory activity of epifriedelanol isolated from <i>Cayratia trifolia</i> against ovarian cancer

Cited by 11 publications

References 19 publications

Analysis of Novel C-X-C Chemokine Receptor Type 4 (CXCR4) Inhibitors from Hexane Extract of Euclea crispa (Thunb.) Leaves by Chemical Fingerprint Identification and Molecular Docking Analysis

Analysis of Novel C-X-C Chemokine Receptor Type 4 (CXCR4) Inhibitors from Hexane Extract of Euclea crispa (Thunb.) Leaves by Chemical Fingerprint Identification and Molecular Docking Analysis

Yield, Characterization, and Possible Exploitation of Cannabis Sativa L. Roots Grown under Aeroponics Cultivation

Yield, Characterization and Possible Exploitation of <em>Cannabis Sativa</em> L. Roots Grown Under Aeroponics Cultivation

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