Assessment of dual-energy computed tomography derived virtual monoenergetic imaging for target volume delineation of brain metastases

Kraft, Johannes; Lutyj, Paul; Grabenbauer, Felix; Ströhle, Serge-Peer; Tamihardja, Jörg; Razinskas, Gary; Weick, Stefan; Richter, Anne; Huflage, Henner; Wittig, Andrea; Flentje, Michael; Lisowski, Dominik

doi:10.1016/j.radonc.2023.109840

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Therefore, the difference of 100 HU in dense material can cause dose errors of about 1%. Previous investigators demonstrated that the VMIs at lower energy (63 keV) could increase the HU value of contrast-enhanced agent and improves objective and subjective image quality compared with the SECT images [ 25 ]. Although the higher image quality may reduce the variability of target delineation depending on the radiation oncologist, but the accuracy of HU calculation might be degraded [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Variation in Hounsfield unit calculated using dual-energy computed tomography: comparison of dual-layer, dual-source, and fast kilovoltage switching technique

Ohira,

Mochizuki,

Niwa

et al. 2024

Radiol Phys Technol

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The purpose of the study is to investigate the variation in Hounsfield unit (HU) values calculated using dual-energy computed tomography (DECT) scanners. A tissue characterization phantom inserting 16 reference materials were scanned three times using DECT scanners [dual-layer CT (DLCT), dual-source CT (DSCT), and fast kilovoltage switching CT (FKSCT)] changing scanning conditions. The single-energy CT images (120 or 140 kVp), and virtual monochromatic images at 70 keV (VMI70) and 140 keV (VMI140) were reconstructed, and the HU values of each reference material were measured. The difference in HU values was larger when the phantom was scanned using the half dose with wrapping with rubber (strong beam-hardening effect) compared with the full dose without the rubber (reference condition), and the difference was larger as the electron density increased. For SECT, the difference in HU values against the reference condition measured by the DSCT (3.2 ± 5.0 HU) was significantly smaller (p < 0.05) than that using DLCT with 120 kVp (22.4 ± 23.8 HU), DLCT with 140 kVp (11.4 ± 12.8 HU), and FKSCT (13.4 ± 14.3 HU). The respective difference in HU values in the VMI70 and VMI140 measured using the DSCT (10.8 ± 17.1 and 3.5 ± 4.1 HU) and FKSCT (11.5 ± 21.8 and 5.5 ± 10.4 HU) were significantly smaller than those measured using the DLCT120 (23.1 ± 27.5 and 12.4 ± 9.4 HU) and DLCT140 (22.3 ± 28.6 and 13.1 ± 11.4 HU). The HU values and the susceptibility to beam-hardening effects varied widely depending on the DECT scanners.

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Section: Discussionmentioning

confidence: 99%

Variation in Hounsfield unit calculated using dual-energy computed tomography: comparison of dual-layer, dual-source, and fast kilovoltage switching technique

Ohira,

Mochizuki,

Niwa

et al. 2024

Radiol Phys Technol

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“…Kraft et al. ( 17 ) further compared the differences between 63 keV reconstructed VMI and 120 kV CT in BM imaging and confirmed that the image quality of VMI was significantly better than that of conventional CT, which could improve the reliability and accuracy of GTV determination in BMs.…”

Section: Advances In Gtv Determination Of Bms Based On Multimodal Ima...mentioning

confidence: 97%

Advances in determining the gross tumor target volume for radiotherapy of brain metastases

Du,

Gong,

Liu

et al. 2024

Front. Oncol.

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Brain metastases (BMs) are the most prevalent intracranial malignant tumors in adults and are the leading cause of mortality attributed to malignant brain diseases. Radiotherapy (RT) plays a critical role in the treatment of BMs, with local RT techniques such as stereotactic radiosurgery (SRS)/stereotactic body radiotherapy (SBRT) showing remarkable therapeutic effectiveness. The precise determination of gross tumor target volume (GTV) is crucial for ensuring the effectiveness of SRS/SBRT. Multimodal imaging techniques such as CT, MRI, and PET are extensively used for the diagnosis of BMs and GTV determination. With the development of functional imaging and artificial intelligence (AI) technology, there are more innovative ways to determine GTV for BMs, which significantly improve the accuracy and efficiency of the determination. This article provides an overview of the progress in GTV determination for RT in BMs.

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“…DECT is a promising CT acquisition technique and has been proven to be advantageous in RT [23] , [24] , [25] , [26] , [27] , both for delineation [28] , [29] and dose calculation [30] , [31] , [32] , [33] , [34] . However, the clinical transition from conventional CT to DECT is not only a simple change of scan protocols, but it impacts the entire RT chain from delineation and treatment planning to image registration at the treatment machine before dose delivery.…”

mentioning

confidence: 99%

From computed tomography innovation to routine clinical application in radiation oncology – A joint initiative of close collaboration

Taasti,

Wohlfahrt

2024

Physics and Imaging in Radiation Oncology

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Assessment of dual-energy computed tomography derived virtual monoenergetic imaging for target volume delineation of brain metastases

Cited by 5 publications

References 28 publications

Variation in Hounsfield unit calculated using dual-energy computed tomography: comparison of dual-layer, dual-source, and fast kilovoltage switching technique

Variation in Hounsfield unit calculated using dual-energy computed tomography: comparison of dual-layer, dual-source, and fast kilovoltage switching technique

Advances in determining the gross tumor target volume for radiotherapy of brain metastases

From computed tomography innovation to routine clinical application in radiation oncology – A joint initiative of close collaboration

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