Assessment of Drinking Water Fortification with Iron Plus Ascorbic Acid or Ascorbic Acid Alone in Daycare Centers as a Strategy to Control Iron-Deficiency Anemia and Iron Deficiency: A Randomized Blind Clinical Study

Nogueira‐de‐Almeida, Carlos Alberto; Mello, Elza Daniel de; Ramos, Adriana P R; João, Camila A; João, Carolina R; Dutra-de-Oliveira, José Eduardo

doi:10.1093/tropej/fmt071

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…There are some studies in Asia regarding iodized water; however, as iodine has limited stability, this strategy is not always cost-effective [103]. Iron and ascorbic acid water fortification to prevent iron deficiency anaemia has been explored and, although successful, is still being researched [112,113].…”

Section: Discussionmentioning

confidence: 99%

Calcium Intake and Health

2019

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There are striking inequities in calcium intake between rich and poor populations. Appropriate calcium intake has shown many health benefits, such as reduction of hypertensive disorders of pregnancy, lower blood pressure particularly among young people, prevention of osteoporosis and colorectal adenomas, lower cholesterol values, and lower blood pressure in the progeny of mothers taking sufficient calcium during pregnancy. Studies have refuted some calcium supplementation side effects like damage to the iron status, formation of renal stones and myocardial infarction in older people. Attention should be given to bone resorption in post-partum women after calcium supplementation withdrawal. Mechanisms linking low calcium intake and blood pressure are mediated by parathyroid hormone raise that increases intracellular calcium in vascular smooth muscle cells leading to vasoconstriction. At the population level, an increase of around 400–500 mg/day could reduce the differences in calcium intake between high- and middle-low-income countries. The fortification of food and water seems a possible strategy to reach this goal.

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Section: Discussionmentioning

confidence: 99%

Calcium Intake and Health

2019

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“…Episodes of diarrhoea were reported by one study to be elevated in children receiving iron supplements along with zinc compared to children in the control groups (Richard et al 2006), but four interventions using other or no co-supplements contradicted this finding (Chang et al 2010;Chen et al, 2011;Richard et al, 2010;Moretti et al 2006). Four other studies (De Almeida et al 2014;Ekoe et al 2020;Andang'o et al 2007;Abizari et al 2012) reported explicitly that no "adverse effects" occurred under iron supplementation, without providing further details on which effects the authors addressed when interviewing the study participants.…”

Section: Adverse Gastrointestinal Effects In Childrenmentioning

confidence: 99%

Preparatory work for the update of the tolerable upper intake levels for iron

Parlesak,

Masino,

Reis

et al. 2024

EFSA Supporting Publications

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The present document has been produced and adopted by the bodies identified above as authors. This task has been carried out exclusively by the authors in the context of a contract between the European Food Safety Authority and the authors, awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.

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“…The search for solutions to redress anemia has been explored in the region at the level of fortification of sugar, 20 milk, 21 and drinking water. 22 The Demographic and Health Surveys across the region are currently showing a reduction in anemia rates in young children and adult women.…”

Section: Where We Have Come In the Regionmentioning

confidence: 99%