Assessment of Disease Activity in Ulcerative Colitis by Faecal Calprotectin, a Novel Granulocyte Marker Protein

Abstract

This study comprised 62 outpatients with ulcerative colitis who underwent 64 colonoscopies. The disease activity was evaluated according to endoscopic and histological criteria. The results revealed a significant correlation between both the endoscopic as well as the histological gradings of disease activity and faecal calprotectin. The median faecal calprotectin levels in the control group (6 mg/l) and in the patients with no or low disease activity (11.5 mg/l) were significantly different (p < 0.0001). The median calprotectin level among patients with active disease was 68 mg/l which was significantly different from the latter group (p < 0.0001). Furthermore, we suggest that the degree of inflammation rather than the extent of the disease determined the faecal calprotectin levels. In conclusion, assessment of faecal calprotectin seems to be a marker of disease activity in patients with ulcerative colitis.

Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration

“…Increased calprotectin concentrations that correlated with the endoscopic-histological grading of intestinal inflammation were detected in adults and children with inflammatory bowel diseases (IBD). [3][4][5] Faecal concentrations of calprotectin were higher in subjects with colorectal carcinoma and in those on short-term anti-inflammatory treatment than in healthy controls. 6,7 In addition, the combination of faecal calprotectin, intestinal permeability test and positive Rome I criteria reliably discriminated between patients with organic and nonorganic intestinal diseases.…”

Fecal calprotectin concentration in the differential diagnosis of bowel diseases

“…После связывания с кальцием белок становится устойчивым к расщеплению под действием лейкоцитарных и микробных ферментов. Установлена высокозначимая роль КП как маркера нейтрофильного воспаления при заболеваниях желудочно-кишечного тракта и показателя интенсивности воспалительного про-цесса в кишечнике [4,5].…”

Non-invasive investigation of inflammatory bowel disease

“…The greatest experience with analysis of faecal proteins is with calprotectin [44][45][46][47][48] . It accounts for up to 50% of the neutrophilic cytosolic protein while being resistant to colonic bacterial degradation.…”