Assessment of different techniques for subcutaneous glucose monitoring in Type 1 diabetic patients during ‘real‐life’ glucose excursions

Abstract

The three investigated technologies had comparable performance. Whereas GRT underestimated actual blood glucose, GDS and MD overestimated blood glucose. Considerable deviations during daily life meal glucose excursions from reference glucose were observed for all three investigated technologies. Present technologies may require further improvement until individual data can lead to direct and automated generation of therapeutic advice in diabetes management.

Periodic Extraction of Interstitial Fluid from the Site of Subcutaneous Insulin Infusion for the Measurement of Glucose: A Novel Single-Port Technique for the Treatment of Type 1 Diabetes Patients

“…3) were similar to or better than those recently observed with commercial continuous glucose sensing devices that use the ISF of insulin-unexposed adipose tissue for the measurement of glucose. 6,[20][21][22][23][24][25][26] For example, recent studies assessing the accuracy of these continuous glucose sensing devices have observed median ARD values (range, 7.7-19.7%) that are similar to 6,20,22 or higher than 21,[23][24][25][26] the median ARD value derived in the present study (8.0%). Furthermore, in a recent study performed in subjects with diabetes, 14 we have assessed the agreement between the plasma glucose concentrations and the ISF glucose levels observed at the insulin delivery site during uninterrupted CSII.…”

“…Overall, these results suggest that estimation of plasma glucose concentrations from the glucose levels observed at the insulin delivery site during both CSII and shortterm interruptions of CSII is feasible and its quality is similar to or better than that of estimating plasma glucose concentrations from glucose levels measured in insulin-unexposed subcutaneous tissue using the latest commercial continuous glucose sensing devices. 6,[20][21][22][23][24][25][26] Therefore, glucose monitoring and insulin delivery could be carried out both simultaneously or sequentially at the same adipose tissue site using a single tissue catheter (single-port treatment approach), thereby leading to the possibility of simplifying and improving glucose management in diabetes.…”

Accuracy Performance of the Medtronic NexSensor® for 6 Days in an Inpatient Setting Using Abdomen and Buttocks Insertion Sites

“…However, the differences between sites in mean agreement rate and mean ARD were not statistically significant, and mechanical disturbances were not assessed for possible effects on accuracy. Published accuracy studies [11][12][13] of Sof-Sensor attached to the Guardian REAL-Time System in adult subjects do not specify which site was used. We are, therefore, reporting the first published study to investigate whether the Sof-Sensor/NexSensor form factor is safe and accurate for use in the abdomen and buttocks sites.…”

A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery

“…Alternative methods for glucose determination which decrease the workload for nursing staff could overcome these issues. Continuous subcutaneous glucose monitoring either by using commercially available continuous monitoring (CGM) systems 5 – 9 or by means of standard microdialysis 10 – 13 has been proven to accurately track changes in glucose concentration in both patients with type 1 and type 2 diabetes mellitus. Not only acute also long long-term clinical outcomes were found to be improved when using CGM systems.…”