Assessment of different sources of variation in the antibody responses to specific malaria antigens in children in Papua New Guinea

Stirnadel, HA; Al-Yaman, Fadwa; Genton, Blaise; Alpers, M. P.; Smith, T.

doi:10.1093/intjepid/29.3.579

Cited by 11 publications

(5 citation statements)

References 41 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This allowed us to examine antibody levels, over time (that is, subsequent antibody response in addition to concurrent responses), within individuals. Our demonstration of the temporal variation in children's antibody levels (figure 1) supports the conclusion of Stirnadel et al [38] that a child's antibody level measured at a single time is not representative of the child's acquired immune response. Therefore, a longitudinal study is a more informative method than are previous crosssectional studies, to examine the relationship between exposure and concurrent, as well as subsequent, antibody development.…”

Section: Discussionsupporting

confidence: 88%

The Effects of Varying Exposure to Malaria Transmission on Development of Antimalarial Antibody Responses in Preschool Children. XVI. Asembo Bay Cohort Project

et al. 2003

View full text Add to dashboard Cite

In areas of intense malaria transmission, malaria morbidity and mortality is highest in children 3-18 months old. Interventions that reduce malaria exposure early in life reduce morbidity but may also delay development of clinical immunity. We assessed the relationship between intensity of malaria exposure and development of antibody responses. Thirty-nine children were monitored monthly, from birth to > or =2.5 years old (1238 observations), and were divided into 3 exposure categories, on the basis of parasitemic episodes or entomological data. Children with low exposure during the first 2 years of life had higher subsequent levels of antibody to merozoite surface protein-1(19-kDa) (a marker of blood-stage responses) by months 24-35 (P<.05). This inverse relationship decreased as children aged. There was no consistent relationship between exposure early in life and subsequent levels of antibody to circumsporozoite protein (a marker of sporozoite-stage responses). These data suggest that, in areas of intense malaria transmission, during the first 3 years of life, interventions that either reduce the number of asexual parasitemic episodes or lower entomological exposure do not delay the development of antibody responses to blood-stage malarial antigens.

show abstract

Section: Discussionsupporting

confidence: 88%

The Effects of Varying Exposure to Malaria Transmission on Development of Antimalarial Antibody Responses in Preschool Children. XVI. Asembo Bay Cohort Project

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Younger girls were found to have P. falciparum parasitemias higher than those in boys in a cross-sectional study of Ghanaian children, but the reverse was true in older age groups [50]. On the other hand, antibody responses to some P. falciparum asexual-stage (non-VSA) antigens were found to be higher in Papua New Guinean girls than in boys, although the statistical significance of this effect was relatively weak and was subsumed by non-sex-related factors [51]. Convincing functional explanations for any of these sex-related effects are lacking, but hormonal changes have been shown to exert strong effects on malaria-related outcomes in older age groups [52,53].…”

Section: Discussionmentioning

confidence: 99%

The Sickle Cell Trait Is Associated with Enhanced Immunoglobulin G Antibody Responses toPlasmodium falciparumVariant Surface Antigens

Cabrera

Cot²,

Migot-Nabias

et al. 2005

J INFECT DIS

View full text Add to dashboard Cite

The sickle cell trait (HbAS) protects against severe Plasmodium falciparum malaria in young African children. We investigated the extent of the association between HbAS and antibodies directed to parasite-derived variant surface antigens (VSAs) on the membrane of infected erythrocytes. We measured immunoglobulin G (IgG) responses with specificity for VSAs of 2 heterologous parasite isolates in 458 Gabonese children aged between 6 months and 11 years. Logistic regression analyses showed a highly significant independent association (P<.001) between carriage of HbAS and the presence of IgG anti-VSA responses; this association was related specifically to IgG1 and IgG4 subclasses in the anti-VSA profile. IgG2 and IgG3 anti-VSA responses were both independently associated with older age, consistent with the pattern observed in semi-immune adults. The results imply that enhanced levels of cross-reactive anti-VSA responses in children with HbAS may be intimately associated with the protection they have against malaria.

show abstract

“…A twin study in Liberia found evidence of heritability in antimalarial antibody responses that did not appear to be determined by HLA class II genes (Sjoberg et al 1992). Familial segregation analysis of immunological responses to malaria antigens in Papua New Guinea has suggested that Mendelian effects might govern specific antigen responses, but the overall picture is complex (Stirnadel et al 1999a(Stirnadel et al , 2000a(Stirnadel et al , 2000b.…”

Section: Family Studiesmentioning

confidence: 99%

How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria

Kwiatkowski

2005

The American Journal of Human Genetics

952

816

View full text Add to dashboard Cite

Malaria is a major killer of children worldwide and the strongest known force for evolutionary selection in the recent history of the human genome. The past decade has seen growing evidence of ethnic differences in susceptibility to malaria and of the diverse genetic adaptations to malaria that have arisen in different populations: epidemiological confirmation of the hypotheses that G6PD deficiency, alpha+ thalassemia, and hemoglobin C protect against malaria mortality; the application of novel haplotype-based techniques demonstrating that malaria-protective genes have been subject to recent positive selection; the first genetic linkage maps of resistance to malaria in experimental murine models; and a growing number of reported associations with resistance and susceptibility to human malaria, particularly in genes involved in immunity, inflammation, and cell adhesion. The challenge for the next decade is to build the global epidemiological infrastructure required for statistically robust genomewide association analysis, as a way of discovering novel mechanisms of protective immunity that can be used in the development of an effective malaria vaccine.

show abstract

Assessment of different sources of variation in the antibody responses to specific malaria antigens in children in Papua New Guinea

Abstract: Temporal variation and clustering of immune responses to specific malaria antigens need to be taken into account when planning, conducting and interpreting immuno-epidemiological and vaccine studies.

Cited by 11 publications

References 41 publications

The Effects of Varying Exposure to Malaria Transmission on Development of Antimalarial Antibody Responses in Preschool Children. XVI. Asembo Bay Cohort Project

The Effects of Varying Exposure to Malaria Transmission on Development of Antimalarial Antibody Responses in Preschool Children. XVI. Asembo Bay Cohort Project

The Sickle Cell Trait Is Associated with Enhanced Immunoglobulin G Antibody Responses toPlasmodium falciparumVariant Surface Antigens

How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria

Contact Info

Product

Resources

About