Assessment of Cytotoxic, Antioxidant, Thrombolytic, Anti Inflammatory and Antimicrobial Activity of Curcuma longa Linn, Cissus quadrangularis and Boerhaavia diffusa Herbal Mixture - An In vitro Study

Yasothkumar, Dinesh; Ramasubramanian, Abilasha; Ramani, Pratibha; Rajeshkumar, S.

doi:10.9734/jpri/2021/v33i60b34805

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Many studies have been performed on the antimicrobial activity using agar well diffusion technique for Curcuma longa Linn, Cissus quadrangularis , and Boerhaavia diffusa formulation by Rajesh Kumar et al [ 26 ]. Studies have been performed on the cytotoxic activity using brine shrimp lethality assay for copper nanoparticles synthesized using nutmeg oleoresin [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Antimicrobial Activity and Cytotoxic Effect of Nigella sativa, Syzygium aromaticum, and Allium cepa Formulation for Use As Antimicrobial Gel or Mouthwash

Begum,

Ramani

et al. 2023

Cureus

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Background: Black cumin/ Nigella sativa is traditionally used for its wide range of medicinal effects. Clove/ Syzygium aromaticum is well known as a natural antibiotic with antiviral, antibacterial, and antifungal properties, and onion/ Allium cepa for its antibacterial properties. The combination of these extracts can effectively have many therapeutic applications. Aim: The aim of the present study is to prepare the formulation of N. sativa, S. aromaticum, A. cepa and to assess the antimicrobial activity and cytotoxic effect of the prepared formulation. Materials and Methods: Antimicrobial activity was carried out by agar well diffusion method and cytotoxic activity was carried out using the brine shrimp lethality assay method. Results: The antimicrobial activity showed the zone of inhibition was highest with Staphylococcus aureus showing 22 mm of zone of inhibition at 100 µl. The cytotoxicity test showed there are about 90% live nauplii in the lowest concentration at 5 µl. Conclusion: The study concluded that the combination extract of N. sativa, S. aromaticum, and A. cepa could be used as an antimicrobial agent. Further research with pathogenic oral microorganisms can validate this formulation as an antimicrobial gel or mouthwash for various pathologies.

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Section: Discussionmentioning

confidence: 99%

Assessment of Antimicrobial Activity and Cytotoxic Effect of Nigella sativa, Syzygium aromaticum, and Allium cepa Formulation for Use As Antimicrobial Gel or Mouthwash

Begum,

Ramani

et al. 2023

Cureus

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“…Inflammation is triggered by damaged living tissues resulting from infections caused by bacteria fungi and viruses and also from trauma. And causative factors of inflammation are physical agents and immune responses developed in the body [ 24 ]. The main function of inflammation is to prevent and eliminate infectious and harmful agents damaging tissues.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activity of lauric acid, thiocolchicoside and thiocolchicoside-lauric acid formulation

Mustafa

2023

Bioinformation

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It is of interest to develop potent and safer anti-inflammatory drugs from plants, as medicinal plants and herbs attained great attention in the medical world due to their multifunctional activities. This article studied the anti-inflammatory effects of lauric acid (LA), thiocolchicoside (TC) and thiocolchicoside–lauric acid (TC-LA) formulation. The anti-inflammatory effects of these compounds were determined by following the methods of inhibition of protein denaturation and proteinase inhibition activity. This was assessed at different concentrations to determine the 50% inhibition concentration (IC50) of the compounds. The result indicated that the activity of LA, TC, TC-LA formulation, and reference drug increased with the increase in the concentration from 10-50 μg/ml, thus proving the activity of LA, TC, and TC-LA formulation against inflammation was in a dose-dependent manner. The percentage of inhibition of protein denaturation was 59.56%, 66.94%, 86.62%, and 60.34% for LA, TC, the combination of TC-LA and standard drug, and the IC50 values were found to be 44.78 μg/mL, 37.65 μg/mL, 27.15 μg/mL and 43.42 μg/mL, respectively. The percentage of proteinase inhibition activity of LA, TC, and a combination of TC-LA and the standard drug was 66.65%, 77.49%, 94.07%, and 69.83%, and IC50 of LA, TC, a combination of TC-LA and standard drug were35.5 μg/mL, 32.12 μg/mL, 24.35 μg/mL and 37.80 μg/mL, respectively. We found out that lauric acid, thiocolchicoside, and thiocolchicoside-lauric acid formulation exhibited significant anti-inflammatory activity.

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A survey on the potential contribution of Reunion Island dye plant species diversity to the market demand for bioactive plant-based dyes and pigments

Andriamanantena¹,

Pithon²,

Dijoux³

et al. 2023

J Ethnobiology Ethnomedicine

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Background Proven toxicity and environmental burdens caused by artificial dyes have motivated dyeing industries to turn to natural alternatives. Plant-based dyestuffs are an interesting group of alternative crops. Reunion Island located in the Indian Ocean is the only European region in the southern hemisphere. It has a great number of assets to find new molecules in the abundant plant biodiversity. However, the dye-producing plants diversity in this island had not been documented to date. Methodology The assessment of the Reunion Island’s plant biodiversity through the “PLANTIN” project allowed us to establish here the first ethnobotanical inventory of plants growing on Reunion Island which may have promising properties as a new alternative source of dyes or colorants for the industries. First, an ethnobotanical survey focused on the uses of plants traditionally used in dyeing was conducted on local stakeholders. Then, the importance of different criteria (e.g., endemicity, accessibility and cultivability, plant organs used for the extraction, industrial interests of the species, etc.) has been considered to establish a classification method of the species, to finally select the most interesting plants which have been further harvested and investigated for their coloring property and dyeing application on natural fibers. Results The results showed that local people have accumulated traditional knowledge of dyeing plants, but that this approach had been discontinued in Reunion. The uses of 194 plant species potentially rich in dyes or pigments, belonging to 72 different families, with diverse botanical status (endemic, native, introduced or alien-invasive species) have been recorded. Then, 43 species were harvested and their coloring property were investigated. It demonstrated that dyes extracted from promising species, e.g., Terminalia bentzoe, Weinmannia tinctoria, Thespesia populnea, Erythroxylum laurifolium, Morinda citrifolia, Leea guinensis, Ochrosia borbonica, Danais fragrans, Terminalia cattapa, Casuarina equisetifolia, and Coccoloba uvifera, amongst others, could be used as new textile dyes. Their efficacy in the wool and cotton dyeing has been successfully demonstrated here. Conclusion These plant-based dyestuffs showed promising coloring properties with different shades that could meet industrial application requirement. It's an area that could promote local cultural inheritance, create opportunity for business and farmers, and that can make a significant contribution to preserving endangered native species by supporting reforestation schemes. Additional researches are in progress to evaluate the safety of these plant-based colored extracts, their chemical composition and biological activities.

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Assessment of Cytotoxic, Antioxidant, Thrombolytic, Anti Inflammatory and Antimicrobial Activity of Curcuma longa Linn, Cissus quadrangularis and Boerhaavia diffusa Herbal Mixture - An In vitro Study

Cited by 4 publications

References 26 publications

Assessment of Antimicrobial Activity and Cytotoxic Effect of Nigella sativa, Syzygium aromaticum, and Allium cepa Formulation for Use As Antimicrobial Gel or Mouthwash

Assessment of Antimicrobial Activity and Cytotoxic Effect of Nigella sativa, Syzygium aromaticum, and Allium cepa Formulation for Use As Antimicrobial Gel or Mouthwash

Anti-inflammatory activity of lauric acid, thiocolchicoside and thiocolchicoside-lauric acid formulation

A survey on the potential contribution of Reunion Island dye plant species diversity to the market demand for bioactive plant-based dyes and pigments

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