Assessment of cytotoxic and genotoxic potentials of a mononuclear Fe(II) Schiff base complex with photocatalytic activity in Trigonella

Mahapatra, Kalyan; Ghosh, Ayon Kanti; De, Sayanti; Ghosh, Noyel; Sadhukhan, Pritam; Chatterjee, Sharmistha; Ghosh, Rajarshi; Sil, Parames C.; Roy, Sujit

doi:10.1016/j.bbagen.2019.129503

Cited by 11 publications

(3 citation statements)

References 54 publications

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“…A broad spectrum of systematic reviews and scientific data demonstrated that fenugreek and its extracts improve glycemic and lipid profiles [ 5 ]. Fenugreek is known to have antioxidant [ 6 ], anti-carcinogenic [ 7 ], gastroprotective [ 8 ], anti-inflammatory [ 9 ], antimicrobial [ 10 ], immunological [ 11 ], antiobesity [ 12 ], and hepatoprotective [ 13 ] effects, and are beneficial to women’s health [ 14 ]. Further, previous studies reported that fenugreek improved cognitive functions and Parkinson’s symptoms and showed antianxiety, antidepressant, and neuroprotective properties [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Fenugreek and Its Effects on Muscle Performance: A Systematic Review

Albaker

2023

JPM

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Fenugreek extracts possess promising physiological and pharmacological properties in human and animal models. This review aims to provide a scientific and comprehensive analysis of the literature on the effects of fenugreek extracts on muscle performance. An extensive online search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. The main medical and scientific engines were searched for articles from May 1981 to May 2021 to capture all scientific studies focused on the effect of fenugreek on muscle and exercise or sport. Out of 81 studies acquired, six eligible randomized controlled trials (RCTs) were included in the qualitative analysis. Four RCTs observed that fenugreek supplementation had significantly improved muscle strength, repetitions to failure (muscle endurance), submaximal performance index, lean body mass, and reduced body fat. Among the remaining two trials, one reported the significant effect of fenugreek extracts on the rate of muscle glycogen resynthesis during post-exercise recovery; however, the other failed to do so. Those two trials were weak, with a minimal sample size (<10). Further, fenugreek glycoside supplementation with sapogenins and saponins reported substantial anabolic and androgenic activity, influencing testosterone levels and muscle performance. It was useful during eight weeks of resistance training without any clinical side effects. Fenugreek with creatine supplementation improved creatine uptake without the necessity of high carbohydrate intake. Hence, fenugreek extracts can be a helpful natural supplement and ergogenic aid for athletes. However, it is better to be aware of doping and liver and kidney damage before using the fenugreek supplement.

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Section: Introductionmentioning

confidence: 99%

Fenugreek and Its Effects on Muscle Performance: A Systematic Review

Albaker

2023

JPM

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“…The obvious role of M n+ in the coordination compounds, transition metal complexes, in the inhibition of the microbial and cancer growth (Tweedy's chelation theory), was explored in many research studies concerning its importance to promote their compounds' bioreactivity. [25][26][27][28][29][30][31][32][33] Considering the progressed biological application of metalated hydrazone derivatives in alternative pharmaceutical and medicinal fields, many published articles highlighted on their bio-applications. [25,26] The biological studies of Fe (III)-complex of isatin carbohydrazone Schiff base ligand was recently reported, which demonstrated valuable obtains.…”

Section: Introductionmentioning

confidence: 99%

“…[29] The antioxidant activity against glioma cells of Fe (III) and Cu (II)-complexes of hydroxy-pyridinylaminophenol was investigated with appreciable results, as reported by Seco et al [30] The biological and phenoxazinone synthase-like activities of various Fe (III) complexes of Schiff base derivatives were explored and presented recently by Ismael et al [31] Assessment of the cytotoxic and genotoxic potentials of Fe (II)-complexes with Trigonella photocatalytic processes was represented recently. [32] Some new Fe (III)-complexes was subjected as antidiabetic candidates, which assigned by Kumar et al [33] The antimicrobial potential of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) complexes of isatin Schiff base was recently studied by Swathy et al [34] and also of Cu (II), Co (II), Ni (II), and Cd (II) chelates of isatin derivatives was soon presented by El-Sonbati el al. [35] As α-glucosidase inhibitors, new category of metal-isatin based Schiff base complexes were published recently by Rahim et al [36] Depending on the literature survey, herein two pincer chelating tri-dentate isatin hydrazone salicylidene ligands (HLSO 3 Na and HLDBu) are coordinated ligands to iron (II) ions to award two various polar and nonpolar Fe (LSO 3 Na) 2 and Fe (LDBu) 2 complexes, respectively.…”

Section: Introductionmentioning

confidence: 99%

Polar and nonpolar iron (II) complexes of isatin hydrazone derivatives as effective catalysts in oxidation reactions and their antimicrobial and anticancer activities

El‐Sayed

Adam

2022

Applied Organom Chemis

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Two iron (II) complexes of various derivatives (polar with 5‐sodium sulfoante group and nonpolar with di‐tert butyl groups, HLSO3Na and HLDBu, respectively) of isatin hydrazones were synthesized within 1:2 molar ratios of Fe2+ ion to the isatin hydrazone ligand giving Fe (LSO3Na)2 and Fe (LDBu)2, respectively. The polar and nonpolar isatin hydrazone derivatives behaved as O,N,O‐tridentate pincer chelating agents with Fe2+ ions. The variation in polarity of the two Fe2+‐complexes controlled their catalytic action in the oxidation of alcohols using tBuOOH (tert‐butyl hydroperoxide). The polar catalyst showed more enhanced catalytic behavior than that of the nonpolar one. The optimized conditions for Fe (LDBu)2 was found to be better at 70°C after 4 h with 86% of benzaldehyde than that with Fe (LSO3Na)2 (at 90°C after 2 h with 84% of benzaldehyde). Their kinetic studies were used to derive the thermodynamic parameters of Ea and ΔG# for the catalytic processes.Biologically, based on their high reactivity toward some bacterial and fungal strains and some human cancer cell lines, the calf thymus‐DNA (ctDNA) interaction of the current compounds were studied. The nonpolar Fe2+‐complex (Fe (LDBu)2) assigned more reactivity with ctDNA more than that of the polar reagent (Fe (LSO3Na)2) and also more than that of their uncoordinated ligands depending on their lipophilicity. Their reactivities toward ctDNA was established spectrophotometrically and within the changes in the DNA solution viscosity. The binding strength was evaluated with the magnitudes of the binding constant (Kb = 3.03, 3.21, 9.79, and 11.51 × 108 mol−1 dm3 for HLDBu, HLSO3Na, Fe (LDBu)2, and Fe (LSO3Na)2, respectively), which supported by the Gibbs' free energy values −3.12, −31.42, −34.18, and −34.58 kJ mol−1, respectively.

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